Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 85 for “"tumor immunity"”.
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Impact Of Cryoablation On Tumor Immunity
… is a minimally invasive procedure for tumor debulking, which has the potential to initiate or amplify tumor immunity through the release of tumor-associated antigens and endogenous danger signals. However, enhanced immunity is rarely observed in treated patients, suggesting the need for …
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Complex N-Glycosylation in Anti-Tumor Immunity
… detection and a lack of effective treatments. Tumor-associated glycans represent a potential anti-tumor target for two reasons: (i) protein glycosylation is known to play a role in tumor progression, and (ii) alternatively glycosylated proteins may function as tumor neoantigens. The …
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Re-Designing Cancer Immunotherapy to Enhance Anti-Tumor Immunity
… (MSC) based immunotherapy to study the immune tumor microenvironment (TME), and optimized radiotherapy delivery with cGAMP and systemic α-PD-L1 immunotherapies. Using MSC, we delivered various forms of anti-CD3 and/or co-signals to explore their contribution to re-activate T cells inside the …
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The impact of intratumor heterogeneity on anti-tumor immunity
… cytotoxic CD8+ T cells, which recognize specific tumor cells and kill them. Specific recognition is bestowed by the presence of neoantigens, derived from mutated sequences arising during tumorigenesis. They are attractive targets because they are specific to tumor cells and have not been subjected …
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Augmenting Anti-Tumor Immunity by Targeting Macrophage Cox-2 in Breast Cancer
… including breast. While the contributions of tumor cell-derived COX-2 are well studied, those of the stroma remain ill-defined. Macrophages, an essential component of the tumor microenvironment, exist within a range of two polar phenotypes, influenced by signals in their local environment: …
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Immune Checkpoint Blockade Induces Gut Microbiota Translocation That Augments Extraintestinal Anti-Tumor Immunity
… lymphoid organs and subcutaneous melanoma tumors. Mechanistically, ICT induces lymph node remodeling and dendritic cell (DC) activation which facilitates the translocation of a selective subset of gut bacteria to extraintestinal tissues which promote optimal anti-tumor T-cell responses in …
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The role of tapasin and its isoforms in antigen presentation and tumor immunity
… machinery (APM) re-expression in MHC-I-deficient tumor cell lines, B16F10 and CMT.64, which are deficient in TAP and tapasin. Virally-driven TAP1 and Tapasin expression increased MHC-I expression in the tumor cell lines, augmented tumor cell immunogenicity, and decreased tumor growth in vivo due …
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Priming systemic anti-tumor immunity via in situ immunomodulation of the tumor microenvironment
… in a subset of cancer patients by driving tumor-directed immune responses. However, many patients do not benefit from such immunotherapies due to immune resistance mechanisms or severe inflammatory adverse events resulting in treatment discontinuation. Direct intratumoral injection of …
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Metabolic Disorders Rewire Systemic and Tumor Immunity to Shape Anti-Tumor Responses in Cancer Patients
… cellular therapies. Rather than acting solely on tumors, metabolic dysfunction dismantles antitumor immunity both locally and distally. Distally, chronic systemic inflammation and stromal remodeling distort the architectural integrity of secondary lymphoid organs. This systemic decay disrupts …
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THE CRITICAL ROLE OF CD4+ TH CELLS IN CD8+ CTL RESPONSES AND ANTI-TUMOR IMMUNITY
… early phase, but also in regulating cellular immunity, perhaps during a later phase. Through enhanced IL-2, CD80 and CD40L singnaling, and weaker peptideMHC I (pMHC) signaling, Th-APCs stimulated naïve CD8+ T cells to differentiate into effector CTLs, capable of developing into, central memory …
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Elucidating the functional states of tumor-resident dendritic cells that drive productive anti-tumor immunity
… DC1, given their superior ability to initiate tumor-reactive cytotoxic CD8+ T cell responses. The exclusion or functional suppression of DC1 in tumors impedes CBT efficacy and enables tumor immune evasion and outgrowth. While the role of DC1 to anti-tumor immunity has been well-established, …
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Immune Cell Subsets Direct or Antagonize Tumor Immunity: Promotion of TH1 Responses in Tumor Vaccination
Tumors evade immune system tumor-controlling functions. T cells critical to antitumor immunity are tolerogenic in tumor-burdened animals, and fail to lyse neoplastic cells. Our goal was to investigate the kinetics of immune dysfunction related to tumor-burdened host (TBH) memory T cell responses …
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Coordinated Blockade of TGF-β and PD-L1 Promotes Anti-Tumor Immunity in Ovarian Cancer Models
… patients. This is due to an immunosuppressive tumor immune microenvironment (TIME) that limits the efficacy of ICB. Resistance to immunotherapy is driven in part by TGF-β signaling in the ovarian TIME, leading to immune suppression, metastasis, and development of malignant ascites. Bintrafusp …
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Tumor immune escape in allogeneic stem cell transplantation: Releasing the brake on graft-versus-tumor immunity
Contains fulltext : 101020.pdf (Publisher’s version ) (Open Access)
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A Novel Syndecan-1 Targeted Therapeutic Antibody Inhibits Macropinocytosis and Induces Anti-Tumor Immunity in Pancreatic Cancer
… multiple myeloma, while its potential in solid tumors is underestimated. More importantly, most of currently anti-SDC1 agents function by exploiting SDC1 as a surface target to deliver cytotoxic payload or facilitate immune cell-mediated killing, while the direct functional inhibition of SDC1 …
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E3 Ubiquitin Ligase Cbl-b deficient T cells resist Treg cell-mediated suppression and enhance anti-tumor immunity
… system that contribute to the regulation of anti-tumor T cell responses. However, studies have suggested that alterations in T cell signaling networks can result in T cells that are resistant to the suppressive effects of Treg cells. Here, we specifically investigated the role of E3 ubiquitin …
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From Naturally Occurring Tumor Immunity to Supernatural T Cells: Isolation and Characterization of a Murine T Cell Receptor Specific for Human Breast and Ovarian Tumor Antigen Cdr2
… degeneration (PCD), a form of neuronal autoimmunity, have a co-occurring natural immune response against a protein called cdr2 in their breast and ovarian carcinomas, and thus provide an innovative starting point for understanding how to harness the immune system to fight cancer. We …
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The Hu Syndrome: At the Intersection of Cancer and Autoimmunity
… Abnormal expression of a neuronal protein by tumor cells in the periphery results in an autoimmune response that then targets both the tumor and the nervous system. These diseases offer a unique opportunity to gain insight into the mechanisms behind both tumor immunity and neuronal …
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Dendritic cell dysfunction restrains cytotoxic T cell responses against cancer
… ICB acts by reinvigorating pre-existing anti-tumor immune responses, and responders are often characterized by the presence of a T cell infiltrate in tumors. However, T cell infiltration does not always correspond to ICB efficacy. Tumor-reactive T cells can acquire persistent dysfunctional …
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