Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"tumor immune microenvironment"”.
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Modulating Tumor Immune Microenvironment Using Heterologous Proteins
… response rates among different cancers. Since, immune cells and the cancer cells share the same genetic background, tumor cells evolve to evade anti-tumor immune responses by either hijacking the pathways already present in the body to avoid overactivation of immune responses or creating a …
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Modulating Tumor Immune Microenvironment Using Heterologous Proteins
… response rates among different cancers. Since, immune cells and the cancer cells share the same genetic background, tumor cells evolve to evade anti-tumor immune responses by either hijacking the pathways already present in the body to avoid overactivation of immune responses or creating a …
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Investigation of Divergent Metabolic Programs in the Tumor-Immune Microenvironment
The current immune metabolism field has been using the term lactate and lactic acid interchangeably, with the notion that lactate and lactic acid are waste products of highly glycolytic cancer cells that negatively affects TIL function and viability to promote tumorigenesis. However, it is yet …
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TimiGP: A Computational Framework to Determine the Tumor Immune Microenvironment Associated with Prognosis and Immunotherapy Response
<p>Accumulating evidence has suggested that the tumor immune microenvironment (TIME) drastically impacts cancer patients’ clinical outcomes, including prognosis and immunotherapy response. However, understanding TIME remains challenging due to its complexity and heterogeneity. In this dissertation, …
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Coordinated Blockade of TGF-β and PD-L1 Promotes Anti-Tumor Immunity in Ovarian Cancer Models
… diagnosis and high recurrence rates. Current immune checkpoint blockade (ICB) therapies show limited efficacy in HGSC, with no approved immunotherapy options for patients. This is due to an immunosuppressive tumor immune microenvironment (TIME) that limits the efficacy of ICB. Resistance to …
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Dissecting the Relationship between Mucin 5AC and the Lung/Gut Microbiome in the Pathogenesis of K-ras Mutant Lung Cancer
… that KRAS-mutant LUAD (KM-LUAD) patients whose tumors harbor high expression of Mucin 5 AC (MUC5AC), a main airway secretory mucin, have a poor prognosis and significantly lower survival rate. Additionally, evaluation of MUC5AC-deletion in our murine model of KM-LUAD demonstrated a significant …
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HEPATOCYTES COORDINATE A SYSTEMIC ENDOCRINE NETWORK IN CANCER
T cell infiltration into tumors is a favorable prognostic feature. However, the majority of solid tumors lack productive tumor T cell immunity, and the mechanisms that coordinate T cell exclusion remain incompletely understood. Accumulating evidence suggests that while cancer cell intrinsic and …
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Effect of Systemic Versus Localized Bacillus Calmette-Guérin Immunotherapy on Bladder Cancer Progression: Novel Role for Trained Immunity
… effect of BCG is incomplete. The tumor immune microenvironment (TiME) is known to influence responses to immunotherapy, and there is mounting evidence that the activation of a systemic immune response is critical for the induction of local anti-tumour responses. Based on this …
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Modulation of Pi3K-Akt Pathway In Colorectal Cancer
… reverse phase protein array (RPPA) on (1) paired tumor biopsies from a clinical trial of MK2206 in PI3K-altered metastatic CRC, (2) PTEN<sup>loss</sup>CRC patient derived xenografts (PDX) treated with MK2206 or carrier, and (3) MK2206-treated cell lines. PD inhibition was deep in cell lines, less …
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The Immune Microenvironment of Microsatellite Instable Endometrial Cancer
… chemotherapy fail. Recent studies in other tumor types have shown that tumors with high microsatellite instability (MSI-H) have increased immunogenicity and response to immunotherapy treatments compared to microsatellite stable (MSS) tumors. Patients with MSI-H EC may also benefit from these …
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Studies of Replication Repair Deficient Brain Tumorigenesis Using Mouse Modeling
… adolescents, and young adults. RRD brain tumors are characterized by universal hypermutation, resistance to standard chemoradiation, and variable susceptibility to immune-based therapies. Despite their clinical relevance, representative immunocompetent models of recently defined RRD …
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The impact of intratumor heterogeneity on anti-tumor immunity
… cytotoxic CD8+ T cells, which recognize specific tumor cells and kill them. Specific recognition is bestowed by the presence of neoantigens, derived from mutated sequences arising during tumorigenesis. They are attractive targets because they are specific to tumor cells and have not been subjected …
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STAT3, NF-κB, and Estrogen Receptor Beta: The Balance of Inflammation in K-ras Mutant Lung Adenocarcinoma
… in which chronic inflammation pervades the tumor immune microenvironment (TIME). Pro-inflammatory pathways dampen the response to treatments, including immune checkpoint inhibitors, necessitating therapies that target this inflammatory signaling network in the TIME. This network is …
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Hypoxia Activated Prodrug and Anti-Angiogenic Therapy Cooperate to Treat Pancreatic Cancer But Elicit Immune Suppressive G-Mdsc Infiltration
… prodrug TH-302 (Evofosfamide) reduces intratumoral hypoxia through a tissue remodeling process, initiates tumor vasculature reorganization, and sensitizes aggressive, spontaneous murine models of prostate cancer to immune checkpoint blockade (ICB). In a clinical trial testing the combination …
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Immune Landscape of early liver metastatic lesions in a Novel Immunocompetent Murine Colorectal Cancer Metastasis Model
… metastatic model, we could detect microscopic tumor lesions. Through genomic and transcriptomic analyses, we pinpointed the importance of macrophages, particularly those expressing high levels of CSF1R, in these microscopic metastatic focal lesions. We conducted macrophage- targeted …
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The Role of Ifitm3 In The Immune Response of Brca-Deficient High Grade Serous Ovarian Carcinoma
… serous ovarian carcinoma (HGSOC) had increased tumor infiltrating lymphocytes (TILs) compared to BRCA-wildtype (WT). To better understand the underlying immune mechanism in these tumors, a preliminary transcriptome analysis was performed on a set of microdissected HGSOC tumor specimens with …
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Impact of Tumor Cell Expressed CD38 on Metastasis and Immune Evasion in Breast Cancer
… elusive. We discovered that hybrid EM murine tumors are enriched in CD38, an immunesuppressive molecule associated with worse clinical outcomes in liquid malignancies but relatively understudied in solid tumors such as breast cancers. Hence, we sought to investigate the role of CD38 in hybrid …