Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"tumor immune evasion"”.
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The Cx3Cl1-Cx3Cr1 Chemokine Axis Contributes to Tumor Immune Evasion and Its Blockade Enhances Responses to Anti-Pd-1 Immunotherapy
<p>CX3CL1 secreted in the tumor microenvironment serves as a chemoattractant playing a critical role in metastasis of CX3CR1 expressing cancer cells. While CX3CR1 can be expressed in both cancer and immune-inhibitory myeloid cells to facilitate their migration, the mechanisms employed by this axis …
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Elucidating the functional states of tumor-resident dendritic cells that drive productive anti-tumor immunity
… DC1, given their superior ability to initiate tumor-reactive cytotoxic CD8+ T cell responses. The exclusion or functional suppression of DC1 in tumors impedes CBT efficacy and enables tumor immune evasion and outgrowth. While the role of DC1 to anti-tumor immunity has been well-established, …
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Deciphering Cancer Metabolic Dependencies in the Tumor Microenvironment
… cells face substantial pressure within the tumor microenvironment. Physical constraints and nutrient limitations in the tumor prevent excessive cell proliferation, while other cell types such as stromal and immune cells can compete with or kill cancer cells. To overcome these restrictions, …
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Targeting T Cells for the Immune-Modulation of Human Diseases
… represent a compelling target population for immune-modulation. In fact, the antigen-specificity, cytotoxicity and promise of long-lived of immune-protection make T cells ideal vehicles for cancer immunotherapy. Interventions for autoimmune disorders, on the other hand, aim to dampen T …