Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"tumor imaging"”.
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Copper-64 radiopharmaceuticals for receptor-mediated tumor imaging and radiotherapy
… analogues labeled with copper-64 for imaging and targeted therapy of SSTr positive cancer. Among three new cross-bridged bifunctional chelators coupled to Y3-TATE, 64Cu-CB-TE2A-Y3-TATE had the most favorable tumor targeting properties. The introduction of ionizable linker groups could …
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Small Molecule Rhenium Carbonyl Complexes: Model Integrated-Design Technetium Estrogen Receptor Ligands for Tumor Imaging
It has been shown that inclusion of an acyl substituent on the cyclopentadiene ring lowers the pKa of the ring hydrogens sufficiently for labeling in an aqueous buffer. A divergent synthetic route to a pair of acyl-substituted cyclopentadienyl complexes, along with their alkyl analogs, has been …
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Efficacy of a Magnetic Drug Delivery System and Development of an Orthotopic Lung Tumor Imaging Model
… in toxicity is observed over time in lung tumor cells exposed to doxorubicin-containing-NIMS. We conclude that 1) the NIMs vehicle can be targeted significantly better as a pulmonary drug delivery agent to specific regions of the lung than liquid suspension and 2) Doxorubicin containing …
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I. Synthesis of Myocardial Imaging Agents for Diagnosis of MCAD Deficiency. II. Synthesis of [fluorine-18] Fluoroaryl Estrogens as Receptor Based Tumor Imaging Agents for Breast Cancer
The synthesis of a (fluorine-18) fluoroaryl estrogen in no-carrier-added form requires the use of ($\sp{18}$F) F$\sp-$. A great amount of effort has been made toward incorporation of ($\sp{18}$F) F$\sp-$onto an electron-rich aromatic ring, but none have found general application. Several strategies …
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Fluorine-18-labeled estrogens, progestins and corticosteroids for receptor-based imaging of breast tumors and target areas of the brain
… 1 and 11$\beta$-ethyl 2 analogues of the breast tumor imaging agent, 16$\alpha$-($\sp{18}$F) fluoro-17$\beta$-estradiol (FES). Tissue distribution studies of 1 and 2 in immature female rats show high selectivity for target tissue (T, uterus) vs non-target (NT, muscle and lung), with T/NT ratios …
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LS301 Fluorescence-guided Photodynamic Therapy of brain cancer using PpIX photosensitizer
<p>Incomplete brain tumor removal always causes neurologic deficit, disease recurrence and high mortality. Protoporphyrin IX (PpIX) accumulated in glioma cells with exogenous 5-aminolevulinic acid (5-ALA) serves as contrast agent for fluorescence-guided surgery and as well as acts as a …
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Synthesis and Characterization of Thermally Responsive Nanocapsules Surface Decorated With Folic Acid For Targeted Drug Delivery and Cancer Destruction
… cancer treatment by facilitating drug targeting, tumor imaging, and treatment enhancements. Previously, we have synthesized and characterized Pluronic F127-chitosan nanocapsules for encapsulation and temperature controlled release of small molecules which could be useful for combining with …
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BIOSENSING OF MATRIX METALLOPROTEINASE ACTIVITY WITH CD-FREE QUANTUM DOTS
… for in vivo applications such as biosensing and tumor imaging. Commercially available QDs contain a notoriously noxious Cd component and therefore continuous research has gone into developing QDs without toxic heavy metals, generally Cd, that would still yield comparable performance in terms of …
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Metal complexes of oxygen-, nitrogen-, and sulphur-containing macrocyclic ligands; synthetic and structural studies
… macrocycle-conjugated antibodies for better tumor imaging while their specificity and efficacy prove excellent for enzyme modelling. In 1987, achievements in this expanding field culminated in the form of a Nobel prize, awarded to C. J. Pedersen, J. M. Lehn and D. J. Cram and marked the …
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Discovery of PSMA-Specific Peptide Ligands and Development of A Noncovalent Method to Attach Chemical Moieties to siRNA
… cancer chemotherapy, PSMA specific ligands for tumor imaging and targeted drug delivery, mechanism and challenge of siRNA based therapeutics, as well as the advantages and clinical applications of peptide nucleic acids (PNAs). In Chapter 3, a PSMA specific peptide ligand was identified using …
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Apple vision pro for intraoperative 3D tumor visualization and surgical guidance
… headset for visualizing and localizing brain tumors during neurosurgical procedures. A complete workflow was developed to overlay a CT-derived 3D tumor model onto a patient-specific head surface mesh obtained using LiDAR scanning and machine-learning–based object tracking. A 3D-printed head …
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Multifunctional Hybrid Theranostic Nanoplatforms for Cancer Imaging and Therapy
… as off-targeting toxicity of nanoparticles, poor tumor accumulation, size, aggregation-imposed vascular confinement, and complex designs for combining imaging and therapeutic agents. To address these issues, this dissertation explores the design, synthesis, characterization, and applications of …
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Leveraging Bio-Inspired Molecules for Cancer Theranostics
… and therapy. Among the most promising of tumor targeting molecules are peptides and antibodies. These bio-inspired molecules can be designed and synthesized to target and respond to cancer cells based on the properties of those cells. Matrix metalloproteinase (MMP) enzymes are …
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Development of Nanoprobes for the Biological Imaging Using Positive Charged Quantum Dots and Upconversion Nanoparticles
… opioid receptor in live cell, to acquire in vivo imaging of tumor expressing integrin ανβ3 in mice, and to detect sequence-specific oligonucleotides. These results show the potential of these nanoprobes to apply for the drug screening and in vivo multiplex imaging.
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Simulation studies on X-ray imaging of brain parenchyma and tumors
Computed Tomography (CT) is an imaging modality with many advantages but is lacking of the ability to image the tissues in the parenchyma of the brain and brain tumours in early stages. Aim of the presented research is to investigate whether CT could be used to image the soft tissue of the brain …