Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"tumor heterogeneity"”.
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Intra-tumor heterogeneity and evolution
… many cancers are extremely hard to treat. Tumors likely resist treatment because each tumor is heterogeneous, and can evolve. Although tumor evolution has long been appreciated, it remains incompletely understood. In this thesis, I will explore two questions related to cancer heterogeneity …
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Dissecting Tumor Heterogeneity In Lung Cancer
… of genetically and phenotypically distinct tumor cells as well as a heterogeneous microenvironment consisting of non-cancer cells and extracellular matrix. Constant interactions among these components ultimately leads to a complex tumor tissue that is ever evolving and poses a therapeutic …
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Quantitative analyses to study tumor clones dynamics and tumor heterogeneity
… manifestations can vary from indolent localized tumor to widespread metastases. This heterogeneity is also observed at the molecular level both inter- and intra-patient. Intra-patient heterogeneity in the clinical setting of men with castration resistant prostate cancer (CRPC) might be …
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RESOLVING TUMOR HETEROGENEITY THROUGH HIGH RESOLUTION MULTI-MODAL TRANSCRIPTOMICS: INTEGRATIVE SINGLE-CELL ATLASES AND GENERATIVE SPATIAL MODELING
Understanding tumor heterogeneity is essential for improving diagnosis, treatment, and drug development in oncology. This thesis explores how cutting-edge transcriptomic technologies and new computational frameworks can be used to dissect, interpret, and model the cellular complexity of solid …
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Application of the single cell genomics in deciphering tumor heterogeneity and its role in tumor progression and drug resistance
Tumor progression, from the single mutated cell to the advanced stages of cancer, represents an evolutionary process. During tumor progression, cancer cells acquire new genetic mutations, becoming more heterogeneous, leading to tumor progression and resistance to therapy. However, clear genetic …
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Deciphering the heterogeneity and spatial architecture of tumors
… of cells, called clones. The resulting intra-tumor heterogeneity evolves temporally, as well as spatially, and is the main cause of relapse and resistance to treatment. With decreasing costs in DNA sequencing technology, rich cancer genomics datasets that effectively capture mutational signals …
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Imaging Based Prediction of Pathology In Adult Diffuse Glioma With Applications to Therapy and Prognosis
… tissue samples. However, the well-known spatial heterogeneity in gliomas limits the ability for clinicians to use that information to make spatially specific treatment decisions. Magnetic resonance imaging (MRI) visualizes and assesses the tumor. But, the exact degree to which MRI correlates with …
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Role of Tumor Suppressor DMP1 in the Initiation and Progression of Breast Cancer
… research have demonstrated complexity and high heterogeneity of this disease. The tumor heterogeneity is a result of many altered genomic, epigenomic, and protein modification states that contribute to a distinctive proliferative advantage. The same deregulations that initiate tumorigenesis of …
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Analysis of Exome Sequencing in Hepatocellular Carcinoma
… occurrence, because it displays a high level of tumor heterogeneity with complex etiology. For unbiased analysis of HCC with diverse tumorigenic backgrounds, a genomewide study that does not target any specific target genes is needed. The mutation of known oncogenes was found from previous …
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Computational imaging and multiomic biomarkers for precision medicine: characterizing heterogeneity in lung cancer.
… 84% of all lung cancer cases. The inherent intra-tumor and inter-tumor heterogeneity in lung tumors has been linked with adverse clinical outcomes. A well-rounded characterization of tumor heterogeneity by personalized biomarkers is needed to develop precision medicine treatment strategies for …
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Molecular profiling in early stage IB1 squamous cell carcinomas of the uterine cervix.
Treatment of tumors of the cervix is based on clinical staging of disease. The International Federation of Gynaecology and Obstetrics system (FIGO staging) has established a system whereby cervical cancers are staged on the basis of anatomical extent of the tumor. Microinvasive tumors most often …
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Rational drug combinations design against intratumoral heterogeneity and clonal evolution
… results in complex clonal architecture and intratumoral heterogeneity in each patient. This also presents challenges for effective therapeutic intervention - with constant selective pressure to induce or select pre-existing resistant subclones toward drug resistance. Mathematical/computational …
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Using Tissue Morphology to Infer Intra-Tumor Variation in Molecular State and Response
Intra-tumor heterogeneity (ITH) presents a significant challenge in the effective treatment of cancer. The traditional approaches to characterize ITH, such as multi-regional sequencing, are cost prohibitive for broad adoption. In contrast, histopathology slides are ubiquitous and, as evidenced by …
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Targeting the Central Dogma to Inhibit Nodes of Convergence in Cancer
… attempt to block one hallmark of cancer and stop tumor growth and progression. However, although these treatments are often initially effective, many cancer patients develop resistance and experience relapse due to redundant signaling or tumor heterogeneity. To avoid resistance mechanisms, cancer …
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Computational Insights Into The Generation of Chromosomal Copy Number Changes
… the diversity of acquired CNVs within distinct tumor tissues. First, we develop a novel method to disentangle the haplotype (the specific alleles on an inherited chromosome) composition of de novo germline duplications to characterize the “grandparental origin” of the extra piece of a …
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INTEGRATIVE GENOMICS UNVEILS TRANSCRIPTION FACTOR ROLES IN CELLULAR FATEAND SPATIALLY RESOLVED TRIPLE-NEGATIVE BREAST CANCER IMMUNITY CAPACITY
… aggressiveness and treatment challenges due to tumor heterogeneity. We propose a novel clinical workflow combining spatial transcriptomics, RNA sequencing, and Immunohistochemistry to analyze TNBC, focusing on PD-L1 status. This method revealed sub-tumoral variations and identified LY6D as a new …
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Longitudinal Clonal Lineage Dynamics and Functional Characterization of Pancreatic Cancer Chemo-Resistance and Metastasization
… techniques, have enriched our understanding in tumor heterogeneity. By dissecting tumors and characterizing clonal lineages, we are better understanding the intricacies of tumor evolution. Tumors are represented by the presence of and dynamic interactions amongst clonal lineages. Each lineage …
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Integrative Bioinformatics Approaches to Elucidating Prostate Cancer Cell Heterogeneity, Plasticity, and Treatment Response
… cancer (PCa) is the most common non-cutaneous tumor in American men, and the second leading cause of cancer-related deaths. PCa-related deaths can be attributed to heterogeneous tumors containing metastatic and therapy-resistant cancer cells. Cancer stem cells (CSC) are an important contributor …
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Histopathological image analysis with connections to genomics
… the variation in nuclear characteristics and tumor heterogeneity is available, which can aid in developing new analytical tools, such as the proposed convolutional neural network for nuclear segmentation, which produces state-of-the-art segmentation results on challenging cases seen in normal …
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