Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"tumor evolution"”.
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Mathematical Modeling of Cancer Tumor Evolution
<p>Several mathematical models of cancer tumor evolution are presented. The aim of this endeavor is to write a thesis that fosters numerical and analytical understanding of certain mathematical models in the area of oncology as well as to offer potential predictive tools of therapeutic and clinical …
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Assessing the impact of tumor evolution on oncology drug development and commercialization
… targeted oncology drugs directed at a specific tumor mutation instead of all forms and mutations of a single target. While oncologic drugs targeted to aberrant or overexpressed pro-proliferative proteins have revolutionized cancer treatment, tumors treated for long periods may mutate over time, …
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Algorithms for single-cell phylogenetics to study tumor evolution and adaptive immune response
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-02-04 without embargo terms
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Computational Approaches to Understand Chemoresistance & Tumor Evolution Using Longitudinal Clinical Data and Lineage Tracing
<p>Tumors are highly heterogeneous and dynamic, continually adapting and evolving in response to their microenvironment as well as external perturbations. Multi-region (spatial) and single cell sequencing has enabled us to anatomize the heterogeneity further and provide evidence of its association …
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Impact of Intratumor Heterogeneity and The Tumor Microenvironment In Shaping Tumor Evolution and Response to Therapy
<p>Intratumor heterogeneity (ITH) is a crucial challenge in cancer treatment. The genotypic and phenotypic heterogeneity underlying diverse cancer types leads to subclonal variation, which may result in mixed or failed response to therapy. The heterogeneity at the tumor level, along with the tumor …
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Interrogation of Changes in Cell State during Tumor Evolution of a Genetically Engineered Mouse Model of Lung Adenocarcinoma
… mouse models of lung adenocarcinoma (LUAD), tumors become more heterogeneous and dysregulate cell identities as they progress and evolve. In this thesis, single-cell RNA-sequencing technology was utilized to understand dynamic changes that occur during tumor evolution both with respect to …
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STING safeguards epithelial genome integrity and protects from carcinogenesis via mitotic checkpoint control
… thereby restraining chromosomal instability, tumor evolution, and providing a therapeutically exploitable vulnerability in cancer therapy.
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Resolving Intra-Tumoral Heterogeneity of Breast Cancer Using Single-Cell Multi-Omics
… epigenetic landscapes. Understanding how intra-tumoral heterogeneity (ITH) influences therapeutic response and drives tumor evolution remains a central challenge in cancer biology. Here, we leverage single-cell multi-omics technologies to dissect the cell states and gene expression programs …
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Intra-tumor heterogeneity and evolution
… many cancers are extremely hard to treat. Tumors likely resist treatment because each tumor is heterogeneous, and can evolve. Although tumor evolution has long been appreciated, it remains incompletely understood. In this thesis, I will explore two questions related to cancer heterogeneity …
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Investigating Metastatic Lineage In Colorectal Cancer By Single Cell Dna Sequencing
… 5-year survival rate). Understanding the CRC tumor evolution may provide valuable insights on how to improve treatment in patients with mCRC. However, the genomic basis of metastasis has been difficult to study, in part due to the extensive intratumor heterogeneity at both the primary and …
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MOLECULAR DISSECTION OF THE CROSSTALK BETWEEN ONCOGENIC AND TUMOR SUPPRESSIVE PATHWAYS: THE CASE OF TAZ-BRCA1 AND MYC-SETX GENETIC INTERACTIONS
Oncogenic and tumor suppressive pathways drive tumor evolution and define genetic liabilities of cancer cells. The investigation of these interactions may reveal novel therapeutic targets that can be exploited in clinics for the selective eradication of cancer cells. With this purpose, we …
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INSIGHTS INTO THE SELECTION AND FUNCTION OF COPY-NUMBER ALTERATIONS DURING CANCER EVOLUTION
Cancer evolution is a complex process mostly driven by genomic instability, including large- and small-scale alterations, such as copy-number alterations (CNAs) or single-nucleotide mutations, respectively. Those alterations play a critical role in tumor development, genetic diversity, and …
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Application of the single cell genomics in deciphering tumor heterogeneity and its role in tumor progression and drug resistance
Tumor progression, from the single mutated cell to the advanced stages of cancer, represents an evolutionary process. During tumor progression, cancer cells acquire new genetic mutations, becoming more heterogeneous, leading to tumor progression and resistance to therapy. However, clear genetic …
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Investigating Invasion In Ductal Carcinoma In Situ With to pographical Single Cell Genome Sequencing
… in which it is possible to delineate genomic evolution during invasion because of the presence of both in situ and invasive regions within the same sample. While laser capture microdissection studies of DCIS-IDC examined the relationship between the paired in situ (DCIS) and invasive (IDC) …
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Decoding Brain Somatic Mosaicism with New Single-Cell Copy Number Analysis Methods
… investigate CNVs in three biological contexts: tumor evolution in paired initial and recurrent meningiomas, age-related genomic changes in neurotypical human brains, and developmental patterns in fetal and postnatal brain tissues. By analyzing both scWGS and multimodal single-cell data (paired …
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Exploring the genetic landscape in cutaneous T-cell lymphoma with short- and long-read sequencing
… chr17q amplification arises very early in tumor evolution, which underlines the central function of this signaling pathway. Analysis of samples from the most common CTCL subtype, mycosis fungoides, revealed a low tumor cell fraction in bulk skin biopsies. To tackle this issue, an approach …
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Subclonal Evolution of Chronic Lymphocytic Leukemia After Allogeneic T Cell Therapies
<p><strong>Subclonal evolution of chronic lymphocytic leukemia after allogeneic T-cell therapies</strong></p> <p>Haven Garber, MD</p> <p>Advisory Professor: Jeffrey Molldrem, MD</p> <p>Intratumoral genetic heterogeneity describes the molecular differences among subclones within a tumor and is a …
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Investigating The Rare Aneuploid Cells in Normal Breast and Therapeutic Resistance in Triple Negative Breast Cancer Using Single Cell Genomics
… their breast tissues. Aside from the aneuploid evolution in normal tissue, we next investigated the tumor evolution and tumor heterogeneity in triple-negative breast cancer (TNBC) under the chemo-resistance context. TNBC is an aggressive subtype that is frequently treated with chemotherapy, but …
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Mechanical Confinement and Heat as Drivers of Aneuploidy in Cancer
… a hallmark of human cancers and contributes to tumor evolution, heterogeneity, and therapeutic resistance. While classically attributed to chromosome mis-segregation during mitosis, emerging evidence indicates that diverse physical and physiological stresses in the tumor microenvironment also …
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Revealing the Mechanisms of Tumorigenesis Through Multi-Omics Analyses
… have revealed a multifaceted etiology of tumorigenesis, extending from just hallmark oncogenic mutations to include large-scale genomic alterations, transcriptomic dysregulation, epigenetic reprogramming, and external influences such as environmental carcinogens and oncogenic pathogens. …
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