Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 701 for “"tumor cells"”.
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Repair in Ehrlich Ascites Tumor Cells
… was induced in freshly drawn Ehrlich ascites tumor cells (EAT), using ionizing radiation, far ultraviolet light (254 nm) or near UV light (365 nm) in combination with 8-methoxypsoralen. UDS was scored by grain counts in autoradiographs following the incorporation of tritium-labelled thymidine. …
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Functional characterization of mobilized tumor cells
… cascade, examining three types of mobilized tumor cells: circulating tumor cells (CTCs), intraoperatively shed tumor cells, and malignant pleural effusions (MPE). We investigated the functional behavior of mobilized tumor cells in order to explain the discrepancy between the number of tumor …
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Telomerase Inhibition and Sensitization of Breast Tumor Cells
… chromosome ends and is obligatory for continuous tumor cell proliferation, as well as malignant progression of breast cancer cells. Telomerase is an attractive anticancer therapeutic target because its activity is present in over 90% of human cancers, including more than 95% of breast carcinomas, …
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Technologies for the isolation of circulating tumor cells
Metastasis, the spread and growth of tumor cells from the primary site to distant organs, is arguably the most devastating and deadly attribute of cancer, and is ultimately responsible for 90% of cancer-related deaths. Circulating tumor cells (CTCs) are exceedingly rare cells found in the whole …
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ROLE OF AUTOPHAGY IN RADIOSENSITIZATION OF BREAST TUMOR CELLS
In MCF-7 breast tumor cells, ionizing radiation promoted autophagy that was cytoprotective; pharmacological or genetic interference with autophagy induced by radiation resulted in growth suppression and/or cell killing (primarily by apoptosis). The hormonally active form of vitamin D, 1,25D3, also …
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Transcriptional Regulation by Hypoxia-Inducible Factors in Tumor Cells
… is the most common extra-cranial solid tumor among children and arises from early sympathetic nervous system (SNS) cells arrested in their development. Generally, a low tumor cell differentiation correlates to poor prognosis. Solid tumors, like neuroblastoma, frequently contain regions …
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Whole genome doubling confers unique genetic vulnerabilities on tumor cells
… (WGD) generates genetically unstable tetraploid cells that fuel tumorigenesis. Cells that undergo WGD must acquire adaptive characteristics to accommodate their tetraploid state, and these adaptations may confer unique vulnerabilities that can be exploited therapeutically. We analyzed the genomes …
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Selective Isolation of Circulating Tumor Cells in Antibody-Functionalized Microsystems
Attachment of circulating tumor cells in microfluidic devices functionalized with proper antibodies was studied. Under static experimental conditions, microchambers were utilized to study the parameters such as cell suspension concentration, incubation time or ambient temperature that may affect …
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Top Down Mass Spectrometry of Archaea and Human Tumor Cells
… applying the top down platform to human HeLa tumor cells. Thirty-four proteins in all were identified, and >90% of these were fully characterized. Several proteins harbored post-translational modifications including N-terminal and internal acetylations, methylations, disulfide bonds, and …
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Loss of Ptdss1 in tumor cells improves anti-PD-1 therapy
… anti-PD-1 therapy. Depletion of PTDSS1 in tumor cells increased expression of IFNγ-regulated genes, including B2m, Cxcl9, Cxcl10, and Stat1. Loss of PTDSS1 in tumor cells also led to increased expression of MHC-I, which was associated with increased expression of cytolytic function related …
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Biological and Clinical Significance of Circulating Tumor Cells in Breast Cancer
Circulating tumor cells (CTCs) represent a unique source of information that might help clarifying numerous aspects of metastasis biology and finding new clinically relevant biomarkers. On the hypothesis that CTCs possess a distinct profile compared to solid primary and secondary lesions, the …
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Chemotaxis of Central Nervous System-derived Tumor Cells within Controlled Microenvironments
… (MB) is a malignant pediatric brain tumor known for its aggressive metastatic potential. Despite the well-documented migration of MB cells to other parts of the brain and spinal column, MB chemotaxis is poorly understood. Herein, we examined the in vitro migratory and cellular …
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Selenium-induced Enhancement of Hematoporphyrin Derivative Phototoxicity in Murine Bladder Tumor Cells
… derivative (Hpd) to murine bladder tumor (MBT-2) cells was studied in vitro. It was observed that selenium in the form of sodium selenite enhanced Hpd-sensitized photodamage in MBT-2 cells under conditions where the selenite alone was non-toxic. Sodium selenite was found to enhance …
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LET dependence of radiation-induced bystander effects using human prostate tumor cells
… research groups have indicated higher numbers of cells exhibiting damage than expected based on the number of cells traversed by the radiation. This phenomenon has been coined as the "bystander effect". The purpose of this study was to characterize the ability of irradiated tumor cells to induce …
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Mechanisms of apoptosis modulation and their contribution to genomic instability in tumor cells
… and sequences. Programmed suicide of cells that were subjected to toxic exogenous and endogenous stimuli plays a key role in understanding cancer development and its treatment. Apoptosis involves sequences of events that may overlap and play contradictory or antagonistic roles in cell …
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Mechanical forces and tumor cells: insight into the biophysical aspects of cancer progression
… progressive metastatic. We have asked how the cells ability to produce mechanical forces changes as the cells progress in metastatic abilities. Furthermore we have asked if metastatic progression changes the cells ability to respond to altered extracellular mechanical cues in two-dimensional …
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The Antitumor Agent, Arglabin-DMA, Preferentially Induces Apoptosis in Human Colon Tumor Cells
… the mechanisms by which Arglabin-DMA inhibits tumor growth <em>in vivo</em> and <em>in vitro</em> are still relatively poorly characterized. To determine the mechanism by which this drug inhibits tumor growth, the effects of Arglabin-DMA in two human colon tumor cell lines (mutant …
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Structure-function analysis of HAMLET (human alpha-lactalbumin made lethal to tumor cells)
… is alpha-lactalbumin, which by unfolding forms a tumoricidal complex with oleic acid called human alpha-lactalbumin made lethal to tumor cells (HAMLET), which kills tumor cells. We investigated how protein sequence variation influences the formation of HAMLET, by comparing human, bovine, equine, …
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Biochemical and Functional characterization of the LEDGF/p75-MeCP2 Interaction in Tumor Cells
… co-activator that protects mammalian cells from various environmental stresses such as oxidative stress, heat shock, and serum starvation. This emerging cancer-related protein is highly expressed in prostate tumors and other tumor types and promotes resistance to chemotherapy in cancer …
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Direct and indirect effects of alpha-particle irradiations of human prostate tumor cells
… of alpha-particle irradiations of human prostate tumor cells, toward the goal of improving the effectiveness of alpha-particle involved radiation therapies such as radioimmunotherapy and BNCT. This project consists of an engineering part and a biological part. In the engineering part, an apparatus …
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