Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"tumor cell lines"”.
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The Unfolded Protein Response Increases Production of Pro-Angiogenic Factors by Tumor Cell Lines
<p>The rapid growth and proliferation of tumor cells will be limited at a stage when they encounter inadequate levels of oxygen and nutrient supply within the poorly vascularized tumor mass. These severe conditions negatively affect the proper folding of nascent proteins in the endoplasmic …
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Gene Therapy for Osteosarcoma : "In Vitro" Characterization of Five Tumor Cell Lines and Development of Treatment Models "In Vivo"
Four human osteosarcoma cell lines (MNNG, TE85, MG63, and G292) and a human-derived osteosarcoma metastatic to murine lung (MLM) were transduced "in vitro" using retroviral vectors containing the Herpes simplex thymidine kinase (HS-tk), human interleukin 2 (IL2). and B-galactosidase (BAG) genes. …
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Tumor Response TCF-4/β-Catenin Regulatory Elements for Enhancing Cancer Gene Therapies
… promoter was tested for its ability to act as a tumor specific regulator of gene expression in a panel of human tumor and normal cell lines. Luciferase reporter assays indicated enhanced activity of the Tcf-4/β-catenin transcriptional element only in tumor cell lines, with minimal activities in …
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Su onkologinėmis ligomis siejamas pre-iRNR splaisingas: splaisingo veiksnių ir hipoksinės mikroaplinkos tyrimas /
… of splicing factors and the expression of tumor-associated mRNA isoforms in healthy and tumor gastrointestinal organ tissues and tumors cell lines, and examines whether/how hypoxic microenvironment in tumor cell lines affects tumor-associated pre-mRNA splicing changes. Studies in this work …
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The Antitumor Agent, Arglabin-DMA, Preferentially Induces Apoptosis in Human Colon Tumor Cells
… the mechanisms by which Arglabin-DMA inhibits tumor growth <em>in vivo</em> and <em>in vitro</em> are still relatively poorly characterized. To determine the mechanism by which this drug inhibits tumor growth, the effects of Arglabin-DMA in two human colon tumor cell lines (mutant …
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Isoprenoid Biosynthesis Pathway as a Drug Target for Bisphosphonates: Transcriptional Profile Investigation
… which are ∼10-1000 fold more potent against tumor cell lines than conventional bisphosphonates due to their ability to inhibit more than one enzyme in the mevalonate pathway.
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The role of tapasin and its isoforms in antigen presentation and tumor immunity
… Class I molecules present peptides to CD8⁺ T cells and are essential for most adaptive immune responses. The first described-spliced tapasin (“isoform 1”) plays a critical role in MHC-I antigen presentation by facilitating peptide loading onto MHC-I molecules in the endoplasmic reticulum (ER). …
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Anticarcinogenic, Antitumor, and Antifungal Properties of Allium Sativum (Garlic)
… immune enhancing, antitumor and antifungal effects of a crude extract and organosulfur compounds of garlic were determined. Diallyl sulfide (DAS), and ajoene each at 100 /xg/ml, and garlic extract (GE, 12.5 mg/ml) inhibited rat liver 9000 X g supernatant (S- 9) dependent …
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CHARACTERIZATION OF THE RNA BINDING MODE OF A PLATINUM-ACRIDINE AGENT
… that shows activity in a broad range of solid tumor cell lines. Unlike the classical platinum-based cross-linking drugs, this agent produces its cytotoxic effect by two synergistic DNA binding mechanisms: monofunctional platination and intercalation of the acridine chromophore. The RNA binding …
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THE ROLE OF DNA SENSOR SIGNALLING PATHWAY IN LYMPHOMA
… defense to eliminate viruses in the body. Intracellular viral infections are detected primarily by immune recognition of viral nucleic acids. Many intracellular DNA sensors induce the expression of pro-inflammatory cytokines and type I interferons (IFN) through the activation of the …
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New quinazoline analogues as NF-κB activation inhibitors
… also reduce the proliferation of numerous tumor cell lines and the mean GI50 for representative compound 2a is 2.88μM on NCI 60 cell lines. Compound 2a can induce significant apoptosis at the concentration of 1μM. The exploration of the mechanism of action of these compounds found that 2a …
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In vitro screening of crude extracts and pure metabolites obtained from marine invertebrates for the treatment of breast cancer
… activity against the drug-sensitive breast tumor cell lines MCF-7, T-47D, ZR-75-1 and MDA-MB-231; the multidrug-resistant and P-glycoprotein (Pgp)-positive breast tumorcell lines MCF-7 Adr and MDA-A1r; and normal and malignant human breast epithelial cells (HBEC) in primary culture. Eight …
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REGULATION OF THE HUMAN NEUROTROPIC POLYOMAVIRUS, JCV, IN THE CENTRAL NERVOUS SYSTEM
… Productive infection of JCV occurs only in glial cells and this restriction is to a great extent due to the activation of the viral promoter that has cell type-specific characteristics. The cell types that support the JCV infection cycle in culture are limited to primary human fetal glial cells …
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β‘-hidroksi- arba α-pakeistų enonų sintezės metodų kūrimas ir susintetintų junginių struktūros - priešvėžinio aktyvumo sąryšio įvertinimas /
… antiproliferative activities in human solid tumor cell lines. In this concept, the main aim of the present work was dedicated to the development of synthetic approaches of these two main structural scaffolds together with their structure-anticancer activity relationship evaluation. It was …
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Vestigial-Like 1 Is A Shared Targetable Cancer-Placenta Antigen Expressed By Pancreatic and Basal-Like Breast Cancers
… for inducing clinical regression by targeting tumor-associated antigens (TAA). To expand the TAA landscape of pancreatic ductal adenocarcinoma (PDAC), we performed tandem mass spectrometry analysis of HLA class I-bound peptides from tumors of PDAC patients. This led to the identification of a …
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Untersuchungen zur Rolle von Neurozytokinen in Hirntumoren
… and the differentiation of neuronal and glial cells. CNTF induces reactive transformation of astrocytes in vivo and has been shown to promote proliferation of neuronal tumor cell lines in vitro. Thus, CNTF is a candidate growth and/or differentiation factor for neuronal and glial tumors. …
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Metabolic Targeting Of Malignant Glioma: Modulation Of Glycolytic Flux By Erythropoietic Factors
… display a highly glycolytic phenotype where the tumors flux glucose to lactic acid independent of oxygen concentration ("aerobic glycolysis"). This altered phenotype is facilitated by expression of primarily fetal enzyme isoforms in these malignant tumors. The end-product lactic acid is rapidly …
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Use Of Cerium Oxide Nanoparticles For Protection Against Radiation-induced Cell Death
… a single 10 Gy dose of ionizing radiation and cell death was evaluated by propidium iodine uptake at 24 and 48 hours after radiation insult. Treatment of rat astrocytes with nanoceria resulted in an approximate 3-fold decrease in radiation induced death. These results suggest that the nanoceria …
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Pharmacological regulation of c-myc gene expression in human breast cancer cells
… studies demonstrated that quinidine causes G1/G0 cell cycle arrest and inhibition of proliferation in MCF-7 human breast cancer cell line (Woodfork, K. et al., 1995). The goal of studies reported here was to understand the molecular mechanisms of c-myc gene regulation by quinidine. C-myc is one of …
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