Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"tumor burden"”.
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Characterizing The Role of Uchl5 In Metastatic Melanoma
… treated with an isotype control led to reduced tumor burden. However, mice that were inoculated with B16F10 shUCHL5 cells and were also treated with anti-mouse PD1 led to increased tumor burden. We find that UCHL5 plays a role in the progression of metastatic melanoma and contributes to an …
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Fast and Robust Automatic Segmentation Methods for MR Images of Injured and Cancerous Tissues
… as in the case of lung with heavy or diffuse tumor. Spatially constrained intensity classification is appropriate for segmentation of noisy images with moderate contrast between tissue regions, where the areas of interest have unpredictable shapes, as is the case in spinal injury and brain …
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Dissecting the Relationship between Mucin 5AC and the Lung/Gut Microbiome in the Pathogenesis of K-ras Mutant Lung Cancer
… that KRAS-mutant LUAD (KM-LUAD) patients whose tumors harbor high expression of Mucin 5 AC (MUC5AC), a main airway secretory mucin, have a poor prognosis and significantly lower survival rate. Additionally, evaluation of MUC5AC-deletion in our murine model of KM-LUAD demonstrated a significant …
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The effect of dietary genistein on breast cancer metastasis
… imaging (BLI) techniques to monitor the tumor progression in vivo of the two dietary groups; 2) to determine the effect of genistein on the tumor burden of the India ink-stained lungs, one of the common metastatic sites; 3) to evaluate the effect of genistein supplementation on overall …
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Identifying a role for the scaffolding protein IQGAP1 in liver health and disease
… and cholestatic stress as well as in liver tumorigenesis. In chapter 2, I review how IQGAP1’s complex structure relates to its dynamic function in cells. In chapter 3, I show that hepatic IQGAP1 expression is increased after a 24-hour fast and that deletion of IQGAP1 blunts the ketogenic …
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Epithelial to Mesenchymal Transition As A Predictor of Response to Polo-Like Kinase 1 Inhibition-Induced Apoptosis In Non-Small Cell Lung Carcinoma
… <p>Here, we demonstrate that mesenchymal NSCLC tumors are more sensitive to PLK1 inhibition compared to epithelial NSCLC <em>in vivo</em> in patient derived-xenograft (PDX) models as well as orthotopic mouse models in which the EMT properties are manipulable by modulating the miR200/ZEB1 axis. …
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The Impact of Adipose-Associated Stromal Cells on the Metastatic Potential of Ovarian Cancer
… progression. We confirmed that ovarian cancer tumor burden was indeed significantly increased in mice on a high fat as compared to low fat diet. To further investigate mechanisms, we examined changes in progenitor populations that occurred in intra-abdominal parametrial (pmWAT), retroperitoneal …
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Differential BCAA Metabolism in Tissues of Tumor-Bearing Mice: A Path to Understanding Cancer Cachexia
… colon cancer mouse model was used to examine how tumor burden alters BCAA metabolism across skeletal muscle, liver, kidney, and adipose tissue. Tumors accumulated BCAAs and showed increased enzymatic activity, whereas peripheral sites displayed widespread BCAA depletion, reduced expression of the …
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STAT3, NF-κB, and Estrogen Receptor Beta: The Balance of Inflammation in K-ras Mutant Lung Adenocarcinoma
… in which chronic inflammation pervades the tumor immune microenvironment (TIME). Pro-inflammatory pathways dampen the response to treatments, including immune checkpoint inhibitors, necessitating therapies that target this inflammatory signaling network in the TIME. This network is …
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Molecular Mechanisms Of Pressure-Stimulated Cancer Cell Signaling
… to increase adhesion, proliferation and overall tumor burden in vivo. My data illustrate that paxillin phosphorylation at tyrosines 31 and 118 is necessary for pressure stimulated adhesion, but tyrosine 81 phosphorylation is not. The phosphorylation events at tyrosine 31 and 118 form a docking …
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Men and Women are Not Just From Different Planets: The Role of Sex-Based Differences in the Prevention of Non-Melanoma Skin Cancer
… light B (UVB) exposure, male mice had greater tumor multiplicity, burden, and grade compared to female mice. Additionally, our acute UVB studies revealed decreased antioxidant capacity and cutaneous inflammation in male mice, suggesting that topical antioxidant or anti-inflammatory agents may …
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Engineered models of the lymphatic stroma to study cell and fluid transport
… cancer cells to our LN stroma model to examine tumor burden. We found that tumor cells invaded the LEC barrier at similar numbers regardless of initial burden. Additionally, at the highest tumor burden, diffusivity in the stroma was significantly decreased. Most excitingly, flow velocity was …
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Therapeutic Effects and Targeted Delivery of Eupenifeldin in Castration-Resistant Prostate Cancer
… system to improve drug accumulation in CRPC tumors while minimizing systemic toxicity. Given the overexpression of prostate-specific membrane antigen (PSMA) in advanced prostate cancer, Eupenifeldin-loaded liposomes functionalized with J-591, a monoclonal antibody targeting PSMA, were …
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The Role of Protocadherin 7 in Lung Adenocarcinoma
… patients. PCDH7 knockout in established lung tumor xenografts led to a significant decrease in phospho-EGFR, leading us to hypothesize that PCDH7 may directly interact with EGFR and modulate signaling through this receptor. We demonstrate that PCDH7 interacts with EGFR in a phospho-dependent …
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The Role of Protocadherin 7 in Lung Adenocarcinoma
… patients. PCDH7 knockout in established lung tumor xenografts led to a significant decrease in phospho-EGFR, leading us to hypothesize that PCDH7 may directly interact with EGFR and modulate signaling through this receptor. We demonstrate that PCDH7 interacts with EGFR in a phospho-dependent …
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Design of an intraperitoneal drug-release device for advanced ovarian cancer therapy
… cancer each year. The standard of care is tumor-debulking surgery followed by adjuvant chemotherapy. Combination intraperitoneal (IP) and intravenous (IV) chemotherapy has been shown to lengthen survival over IV therapy alone. Large-volume infusions, drug-associated toxicity, and …
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ACETYL COA CARBOXYLASE 1 IN PROSTATE CANCER AS A CHEMOTHERAPEUTIC TARGET
… specific deletion of ACC1 activity reduced tumor burden in 12-week-old C57BL/6J mice. However, prostate tumors are able to bypass the requirement for ACC1 by the time mice are 24-weeks of age. Metabolic analysis revealed different prostate cancer cell lines prefer to utilize different …
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Evaluating The Therapeutic Efficacy of Grb2 Inhibition In Ovarian Malignancies
… to study the biological effects of L-Grb2 on tumor growth. <em>In vitro</em> experiments (cell viability assay, Western blot analysis, siRNA transfection, and reverse phase protein array) were carried out to elucidate the mechanism and potential predictors of tumor response to L-Grb2.</p> …
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Investigating The Role of Exosomal Communication In The Glioma Microenvironment
… human gliomas, the most aggressive human brain tumors, contains both glioma stem cells (GSCs) and cells that resemble human bone marrow-derived mesenchymal stem cells (BM-MSCs), called Glioma Associated-MSCs (GA-MSCs). We have also shown that GA-MSCs generate a cytokine-mediated increase in the …
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Improving cancer therapy strategies via cellular stress and immune modulation
… therapeutic strategies designed to overcome tumor resistance and improve therapeutic efficacy. The first component of this work focuses on the small molecule ErSO, which induces cell death through hyperactivation of the unfolded protein response (UPR). Preclinical studies in osteosarcoma …
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