Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"tumor associated macrophages"”.
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Tumor Associated Macrophages in a MaFIA Mouse Model
Recent evidence has shown the important role of macrophages in both tumor development and progression. To investigate the role of macrophages we used a mouse model known as MaFIA (Macrophage Fas Induced Apoptosis) mice that allows for the selective deletion of macrophages. Mice were given melanoma …
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The role of tumor-associated macrophages in pancreatic cancer
… and most patients die of distant metastasis. Tumor-associated macrophages (TAMs) are essential components of the tumor microenvironment (TME) and play essential roles in the regulation of tumor progression and immunity. In recent years, macrophage-targeted monotherapy or integrated therapies …
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Investigating the Heterogeneity of Tumor Associated Macrophages in Human Hepatocellular Carcinoma
… However, a high density of regulatory macrophages is correlated with poor prognosis in HCC patients. Therefore, we hypothesized that macrophages in HCC liver are distinct from their healthy counterparts and exhibit a clear tumour-driven regulatory pro-tumourgenic phenotype. With our …
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CROSSTALK BETWEEN GLIOMA CELLS AND TUMOR ASSOCIATED-MACROPHAGES: MECHANISMS AND THERAPEUTIC STRATEGIES
Macrophages are highly plastic cells, able to respond to several microenvironment signals acquiring distinct functional phenotypes. In Glioblastoma (GBM), the most common malignant brain tumor, tumor-associated-macrophages (TAMs) represent the major infiltrating immune cell populations and are key …
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The impact of Wnt5a signaling and tumor associated macrophages in breast cancer
… death for women with breast cancer is secondary tumors. Downregulation of Wnt5a in primary ductal breast cancer has been correlated with poor outcome and higher tumor grade and found to be an independent predictor of recurrence. The ability of Wnt5a to inhibit tumor progression can partly be …
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Targeting and Reprogramming Tumor-Associated Macrophages with Polymeric Nanoparticle-Mediated mRNA Delivery for Cancer Treatment
… from genetic changes and are influenced by the tumor microenvironment (TME), where tumor-associated macrophages (TAMs) play a key role. TAMs can be divided into pro-inflammatory M1 type macrophages and anti-inflammatory M2 type macrophages. Reprogramming TAMs from an M2-type to an M1-type is …
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Dissecting the Role of Hedgehog Signaling in Tumor-associated Macrophages and Immunosuppression in the Tumor Microenvironment
<p>Macrophages are terminally differentiated cells of the hematopoietic system that are involved in various important cellular processes, including protection against pathogenic infections, inflammation and tissue homeostasis. Additionally, macrophages coinhabit with malignant cells in various …
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ROLE OF P50 NF-KB IN MACROPHAGE MIGRATION
Tumor Associated Macrophages (TAM) and lipopolisaccharide- (LPS)-tolerant macrophages share several characteristics, such as a massive accumulation of the p50 NF-B homodimer in the nucleus and the incapacity to express strong inflammatory programs (eg. impaired TNF production) in response to …
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Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation To Promote Immune Suppression
The immunosuppressive tumor microenvironment (TME) is a major barrier to immunotherapy. Within solid tumors, why monocytes preferentially differentiate into immunosuppressive tumor associated macrophages (TAMs) but not immunostimulatory dendritic cells (DCs) remains unclear. Using multiple murine …
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ELUCIDATING THE FUNCTIONS OF TAp73 IN BREAST CANCER
… results suggested that TAp73 can function as a tumor promoter in tumorigenic cells and as a tumor suppressor in cancer-associated fibroblast and tumor-associated macrophage. The PyMT mice with TAp73 knockout in the tumorigenic mammary epithelial cells had a longer latency in the development of …
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Macrophage-mediated resistance mechanisms against MAPK inhibitory by cancer therapeutics
… the cellular and molecular contributions of the tumor microenvironment to MAPK inhibitor response. First, we employ a computational framework using published bulk and single-cell patient gene expression data to investigate immune cell correlates of MAPK inhibitor resistance, and subsequently …
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Synthetic Essentiality of Tdo2 In Apc-Mutated Colorectal Cancer
… of the adenomatous polyposis coli (APC) tumor suppressor is</p> <p>common genetic event across many cancers and serves a critical initiating</p> <p>event in the majority of sporadic colorectal cancers (CRC). The WNT/APC</p> <p>pathway remains an elusive target for cancer, prompting us to …
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Mechanisms of Intercellular Communication During Breast Cancer Progression Through Metastasis
… cancer cells, or between cancer cells and the tumor microenvironment is well established, additional research on specific molecular and cellular mechanisms underlying these interactions is necessary to develop novel therapeutic strategies. One mechanism that facilitates metastasis is …
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JAG1 Blockade With oHSV Polarizes Macrophages to Create a Unique Vulnerability for Cetuximab-Mediated Senolysis of Glioma Cells
… Notch signaling and myelosuppression in the tumor microenvironment (TME) of preclinical models. In the clinic, upregulation of JAG1 gene expression was observed in recurrent high-grade glioma patients treated with CAN-3110. Since JAG1 is expressed on both glioma cells and tumor-associated …
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Targeting Myeloid Protein Kinase C Signaling to Overcome Immune Suppression and Improve Immunotherapy in Cancer
Checkpoint immunotherapy unleashes T cell antitumor potential which has revolutionized cancer treatment showing unprecedented long-term responses. However, most patients do not respond to immunotherapy which often correlates with a dysfunctional or immunosuppressive myeloid compartment. …
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Exosomal Communication By Metastatic Osteosarcoma Cells Modulates Alveolar Macrophages to An M2 Tumor-Promoting Phenotype and Inhibits Tumoricidal Functions
… and there is a link between the predominance of tumor promoting immunosuppressive M2<em> </em>macrophages in the metastases and poor patient survival. By contrast, M1<em></em>macrophage predominance correlates with longer survival. M2 macrophages can be induced by various stimuli in the tumor …
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Intratumoral Sting Activation Sensitizes Poorly Immunogenic Cancers to Checkpoint Blockade Immunotherapy
<p>Unprecedented durable tumor regression can be achieved in patients with checkpoint blockade immunotherapy, yet these responses are rare and are not observed in all tumor types. Castration resistant prostate cancer (CRPC) and pancreatic adenocarcinoma (PDAC) are two common lethal cancers that …
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The Role of Inflammation and Nitric Oxide Synthase 2 in Triple-Negative Breast Cancer Metastasis
… nitric oxide synthase 2 (NOS2) expression in tumor cells indicates poor prognosis, poor survival, and chemotherapeutic resistance in triple-negative breast cancer (TNBC) patients. The tumor microenvironment (TME) comprises various cell types that play a role in tumor survival and invasion by …
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The Omental Fat Band as an Immunomodulatory Microenvironment for Ovarian Cancer
… shifted to the complex interactions between the tumor cell and the surrounding microenvironment. Ovarian cancer has one of the highest incidence-to-death ratios of all cancers, and is typically asymptomatic until the later stages, often resulting in metastasis prior to discovery. Naturally …
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