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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"tumor antigen"”.
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A Study of the Extraction and Dna Binding Properties of Simian Virus 40 Tumor Antigen
Made available in DSpace on 2014-12-14T04:27:46Z (GMT). No. of bitstreams: 1 7913620.pdf: 6964999 bytes, checksum: e1e92e09da3a24c6454bc7df96cf1643 (MD5) Previous issue date: 1978
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CROSS-REACTIVITY BETWEEN MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN AND ROUS SARCOMA VIRUS-INDUCED TUMOR ANTIGEN IN CHICKENS
… between major histocompatibility complex (MHC) antigen and Rous sarcoma virus (RSV)-induced tumor associated antigen (TAA) in chickens was investigated. The B erythrocyte allcantigen locus was the genetic marker for the MHC. B2B2 and B5B5 chickens from crosses of highly inbred lines 6-1 and 15-1 …
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Incorporation of tumor antigen epitopes into cytokine signal peptides enhance the efficacy of immuno-gene therapy
… in activating and expanding T cell responses to antigens, cytokines are comprehensively studied for cancer therapy. The efficacy of cancer immunotherapy is diminished by the fact that spontaneous tumors often downregulate antigen expression and/or presentation. The density of tumor antigen in …
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A Study of Cell Surface Change After Viral Transformation by Iodination and Cell-Cycle Dependent Phosphorylation of Sv-40 Large Tumor Antigen
… dependent phosphorylation of the large tumor antigen induced by SV-40 in human cells.
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From Naturally Occurring Tumor Immunity to Supernatural T Cells: Isolation and Characterization of a Murine T Cell Receptor Specific for Human Breast and Ovarian Tumor Antigen Cdr2
… PCD patients, suggesting that CTLs mediate tumor immunity in these patients. Cdr2 is expressed by a large proportion of breast and ovarian tumors from individuals who do not develop neurological disease, suggesting that immune responses to this antigen may develop independently of autoimmune …
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Kir-Based Inhibitory Cars Overcome Car-Nk Cell Trogocytosis-Mediated Fratricide and Tumor Escape
… to effector cells. Using multiple in vivo tumor models and clinical data, we report that chimeric antigen receptor (CAR) activation in natural killer (NK) cells promoted the transfer of the CAR-cognate-antigen from tumor to NK cells, resulting in (1) lower tumor antigen density, thus …
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Factors contributing to T cell persistence in a tolerizing tumor environment
… immune cells responsible for eradicating tumor cells. However, these T cells can be rendered ineffective through tolerance. Yet in various mouse models and human patients, tolerant T cells persist. The aim of this project is to identify factors that support T cell persistence in a …
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Marcatura di molecole biologiche a funzione antigenica per lo studio e la caratterizzazione di protocolli di vaccinoterapia in oncologia medica
… the expression of molecules that enhance antigen capture and selective receptors that guide DCs to and from several sites in the body, where they elicit the T cell mediated immune response. For these features, immature DCs (iDC) loaded with tumor antigen and matured (mDC) with a standard …
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Characterization of Mouse Prostate Tumor-Infiltrating Leukocytes
… an intact murine immune system and a prostate tumor that expressed a naturally processed weak tumor antigen. Vaccination trials for cancer patients have detected tumor-specific immune cells in the peripheral lymphoid organs such as blood, even with progressing disease. This observation prompted …
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Efficacy and Mechanism of Â-Defensin2 Fused Antigen Protein Vaccines
… fusing adjuvant murine â-defensin2 (mBD2) to an antigen in order to elicit stronger anti-antigen immune responses are referred to as murine â-defensin2 (mBD2) vaccines. Previous studies have validated the potential of mBD2 vaccines, thus in this study we focus on increasing vaccine efficacy as …
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Biophysical characterization of high affinity engineered single chain Fv antibody fragments
… for very high affinity binding. Two single chain antigen-binding fragment (scFv) antibody systems that were engineered to obtain higher affinity interactions through directed evolution were probed using biophysical techniques to illuminate affinity modulation in proteins. First, anti-c-erbB-2 …
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Cross-Presentation Is A Source of Tumor Antigens For Multiple Myeloma Immunotherapy
… and adaptive arms of the immune system where antigen presenting cells (APCs) prime cytotoxic T cell responses. We have recently identified cross-presentation as a mechanism by which solid tumors present exogenous antigens. We therefore hypothesized that multiple myeloma would be capable of …
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ROLE OF IL-10 PRODUCING EOMES+ TR1-LIKE CELLS IN MELANOMA
… adaptive immune system’s ability to eradicate tumors are crucial for the development of effective cancer immunotherapies. In particular, the immunosuppressive functions of FOXP3+ T regulatory cells (Tregs) and EOMES+ type 1 regulatory T (Tr1) cells, which produce the anti-inflammatory cytokine …
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Enhancing efficacy of oncolytic myxoma virus and adoptive T cell therapy against tumors
… red fluorescent reporter protein, and the antitumor effect of the virus. Interleukin-15 (IL15) is an immunomodulatory cytokine with significant potential for stimulating anti-tumor T lymphocytes and NK cells. Co-expression of IL15 with the α subunit of IL15 receptor (IL15Rα) greatly enhances …
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Engineering immunity : enhancing T Cell vaccines and combination immunotherapies for the treatment of cancer
… response can be stimulated to elicit durable tumor regressions in metastatic cancer, but these dramatic responses are confined to a minority of patients¹-³. This outcome is likely due in part to the complex network of immunosuppressive pathways present in advanced tumors, which necessitates …
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BOTH EFFECTOR AND INHIBITORY IMMUNE MECHANISMS ARE AMPLIFIED IN CASTRATION-RESISTANT PROSTATE CANCER
… ablation leads to apoptosis of primary prostate tumor and transient potentiation of immune function. However, immune inhibitory mechanisms employed by the tumor eventually prevent prolonged anti-tumor immunity. The long-term effects of androgen ablation on immune function remain poorly …
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Leveraging Innate Immune Sensors to Generate Durable Anti-Glioma Adaptive Immune Responses
… aggressive primary brain malignancy harboring a tumor microenvironment that is mostly devoid of T cell effector infiltration but is dominated by immune suppressive microglia, macrophages, and myeloid-derived suppresser cells. These innate immune cells display impaired phagocytosis and antigen …
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A materials-based approach for localized delivery of cancer immunotherapy
… therapy may be critical to maximizing anti-tumor responses in the clinic. Inflammatory cytokines such as interleukins-2, 12 and 15 promote potent anti-tumor immunity, but systemically administered cytokines are also highly toxic. In this thesis, we engineered cytokines with a peptide tag …
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Integrin-targeted cancer immunotherapy
… thesis, we instead exploit integrins as a target tumor antigen in the context of immunotherapy. The engineered cysteine knot peptide, 2.5F, is highly crossreactive and capable of recognizing multiple RGD-binding integrins. Our initial attempts to utilize this binder as a targeting moiety for …
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Characterization of the Paraneoplastic Cerebellar Degeneration Antigen Cdr2
… system. It is believed to arise when these tumors ectopically express a neuron-specific protein, thereby initiating an anti-tumor immune response that subsequently develops into a neuronal degeneration. Three cerebellar degeneration related (cdr) genes encoding putative antigens were …
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