Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 40 for “"tumor angiogenesis"”.
-
NMR imaging of tumor angiogenesis
… the US annually. A common feature of most human tumors is their ability to induce the proliferation of new blood vessels, i.e. angiogenesis. Considerable evidence now exists which demonstrates that these tumor vessels are associated with a distinct range of morphological and physiological …
-
Paxillin-dependent control of tumor angiogenesis
Angiogenesis- the growth of new capillaries from existing vessels- is required for tumor growth; however, tumor vessels exhibit abnormal structure and function, which impairs the targeted delivery of anti-cancer agents. While directional migration of capillary endothelial cells is critical for …
-
Defining the Role of PIM1 in Tumor Angiogenesis
… is upregulated in response to hypoxia in solid tumors via disruption of its proteasomal regulation. Here, I establish that heightened PIM1 expression promotes tumor angiogenesis via direct phosphorylation of HIF-1. Using orthotopic and xenograft models of prostate and colon cancer, we …
-
Tumor Angiogenesis is all Tied up in Tie2-Expressing Macrophages
The impact of the immune system on solid tumor formation and malignant disease has been the focus of much study over the last several decades. Elimination of macrophages from mouse models for malignancy result in decreased in tumor angiogenesis, progression and malignancy. Further migration of …
-
MOLECULAR ASPECTS OF ENDOTHELIAL CELL FUNCTION AND HYPOXIA-DEPENDENT TUMOR ANGIOGENESIS
… is an inherent feature of rapidly expanding tumor tissue. In order to survive in the hostile, hypoxic environment and to restore the supply of oxygen and nutrients tumor cells activate a variety of adaptive mechanisms. Among them, hypoxia-induced angiogenesis, i.e. the formation of tumor …
-
Dual Targeting of Tumor Angiogenesis and Chemotherapy By Endostatin- Cytosine Deaminase-Uracil Phosphoribosyltransferase
<p>Antiangiogenesis is a promising anti-tumor strategy through inhibition tumor vascularformation to suppress tumor growth. Targeting specific VEGF/R has been showntherapeutic benefits in many cancer types and become a first approvedantiangiogenic modalities by Food and Drug Administration (FDA) in …
-
Effekt einer Antagonisierung der alpha- v-Integrine auf Angiogenese, Wachstum und Metastasierung solider Tumoren in vivo
… is a potential new form for treatment of solid tumors. The alpha-v-integrins ( avb3, avb5) mediate the contact of activated endothelial cells to proteins of the extracellular matrix during tumor angiogenesis as a prerequisite for survival of endothelial cells. The aim of this study was to …
-
Generating single-domain antibodies against fibronectin splice variants
… purified antigen cocktails, or from the ECM of tumor samples, and antibody libraries were generated. Using these libraries to pan against, I selected for VHH which bind to EIIIA and EIIIB. Since these splice variants are upregulated in tumor angiogenesis and are rarely seen elsewhere in adult …
-
Role of the Activin/Follistatin system during angiogenesis and tumor progression
… expression of AC. The effect of FS on angiogenesis in vivo has been confirmed in a rabbit cornea assay. The aim of this study was to examine the hypothesis that AC inhibits angiogenesis and in particular to examine the role of AC/FS system in tumor angiogenesis and tumor growth. To …
-
Differential Angiogenic Capability and Hypoxia Responses in Glioma Stem Cells
… highly lethal cancers characterized by florid angiogenesis. Glioma stem cells (GSCs), enriched through CD133 (Prominin1) selection, are highly tumorigenic and therapy resistance. However, the mechanism through which GSCs promote tumor growth was largely unknown. As we noticed that tumors …
-
Application of a High‑Resolution Computed Radiography System in Detecting an Iodinated X‑ray Contrast Agent: Small Animal Phantom Study
<p>Tumor angiogenesis, the creation of new blood vessels, is the characteristic of solid tumors and crucial for their development. Iodinated contrast agents are used to increase the X‑ray detectability of zone of angiogenesis, and thus providing a means for tracking tumor growth.</p> <p>The overall …
-
A quantitative analysis of the development and remodeling of blood vessels in tumors : contribution of endothelial progenitor cells to angiogenesis and effect of solid stress on blood vessel morphology
Angiogenesis plays a key role in tumor growth. The dependency of tumors on angiogenesis has rendered it a promising therapeutic target. However, to date, this promise has gone unfulfilled in the clinic, suggesting that the current understanding of angiogenesis is insufficient. The objective of this …
-
The Influence of Human Umbilical Vein Endothelial Cells in the Formation of Glioblastoma Spheroids in Three-Dimensional Microwells
… (GBM) is the most malignant primary brain tumor with a high infiltrative capacity and increased vascularity. Despite current therapies overall patient survival rate is still poor. Therefore, alternative therapies have been considered for GBM treatment such as oncolytic viruses (OVs). The …
-
Sviluppo di un tomografo multi-energy per lo studio pre-clinico di nuove metodiche diagnostiche finalizzate al riconoscimento precoce della patologia tumorale
… methods for the early detection of the tumors in small animals. An innovative technique, the Triple-Energy Radiography with Contrast Medium (TER), has been successfully implemented on our system. TER consist in combining a set of three quasi-monochromatic images of an object, in order to …
-
Assessment and Diagnosis of Human Colorectal and Ovarian Cancer using Optical Imaging and Computer-aided Diagnosis
… diagnosis parameter associated with early tumor development and progression. To characterize the differences between benign and malignant colorectal tissues, we have created an automated optical scattering coefficient mapping algorithm using an optical coherence tomography (OCT) system. A …
-
High-Speed Photoacoustic Microscopy In Vivo
… oxygen saturation, which closely correlate with angiogenesis and hypermetabolism--two hallmarks of cancer. To translate PAM to the clinic, both high imaging speed and high spatial resolution are desired. With high spatial resolution, PAM can detect small structural and functional changes early; …
-
Anti-VEGF Therapy Modulates Immune Cell Infiltration and Function in Multiple Breast Cancer Models
… to these malignant cells participates in tumorigenesis and is required for the tumor to advance past the hyperplastic stage. Angiogenesis, or expansion of the existing vascular network, is required for the growth of solid tumors. For this reason, tumor angiogenesis is an attractive target …
-
The role of CysLT1R in animal models of colorectal cancer
… colon cancer, we were able to observe a reduced tumor growth in response to CysLT1R antagonist treatment. The inhibition of the tumor growth was accompanied with changes in proliferation and apoptosis as determined by reduced Ki-67 expression, increased expression of p21WAF/Cip1, cleaved caspase …
-
Radiosensitization of Head & Neck Carcinoma Cells by Linifanib, A Receptor Tyrosine Kinase Inhibitor
<p>Tumor angiogenesis is a hallmark of advanced cancers and promotes invasion and metastasis. Over 90% of head and neck squamous cell carcinomas (HNSCC) express angiogenic factors such as vascular endothelial growth factor (VEGF). Since radiotherapy is one of the most commonly used treatments for …
Page 1 of 2