Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"tumor ablation"”.
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Image-guided robots for dot-matrix tumor ablation
… imaging now provides detailed images of solid tumors inside the body and miniaturized energy delivery systems enable tumor destruction through local heating powered by a thin electrode. However, the use of thermal ablation as a first line of treatment is limited due to the difficulty in …
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Determining the Oncological and Immunological Effects of Histotripsy for Tumor Ablation
… non-invasive, non-thermal, image-guided cancer ablation modality that has recently been approved for its first clinical trial in the United States (NCT04573881). Histotripsy utilizes focused ultrasound to generate acoustic cavitation within a tumor to mechanically fractionate targeted tissues. …
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Development of an Injectable Ablative Therapy for Resource-Limited Settings: Applications in Tumor Ablation
… of an existing technique entailing intratumoral injection of ethanol to induce necrosis of malignant cells (termed “ethanol ablation”) utilized to reduce tumor volume with either curative or palliative intent. Modifications are based on analysis of the mechanics of the injection process …
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Photothermal energy conversion by plasmonic nanoparticles
… of these nanoparticles, like photothermal tumor ablation, drug delivery, and microfluidic devices, depend on the conversion of light to heat. In this dissertation, we compare three nanoparticle species' theoretical absorption efficiency from electromagnetic calculations with their …
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Exploring Interactions Between Malignant Brain Cancer Cells and the Tumor Microenvironment Following High-Frequency Irreversible Electroporation
… irreversible electroporation (H-FIRE) is a novel tumor ablation therapeutic that applies bipolar, high-frequency pulsed electric fields to tumors, triggering the formation of irreversible membrane pores and to induce tumor cell death. H-FIRE has demonstrated pre-clinical and clinical utility as a …
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Mechanical High-Intensity Focused Ultrasound (Histotripsy) in Dogs with Spontaneously Occurring Soft Tissue Sarcomas
… tissues. The acellular debris may include tumor antigens with preserved immunogenicity and the potential to generate systemic immune response against tumor cells. Soft tissue sarcomas (STS) are a common form of cancer in dogs with biological behavior similar to STS in humans. Long-term …
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Gene Therapy for Osteosarcoma : "In Vitro" Characterization of Five Tumor Cell Lines and Development of Treatment Models "In Vivo"
… showed a bystander effect (whereby wild type tumor cells are killed by co-incubation with HS-tk positive tumor cells and GCV). MNNG cells were used to develop a series of experiments in athymic nude mice to investigate the utility of gene therapy for the treatment of experimental …
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Molecular basis of immunotolerance in canine neoplasia
… soft tissue sarcomas are poorly immunogenic, as Tumor infiltrating Lymphocytes are lacking, or when present they are usually at the periphery of the tumor. Still, soft tissue sarcomas are considered immunosuppressed. Checkpoint molecules from the PD-axis are overexpressed in numerous human …
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Development and Characterization of Tunable, Bioinspired Electrospun Constructs for Skeletal Muscle Engineering
… of high intensity sports injury, trauma or tumor ablation, affects more than 250,000 civilians each year in the U.S. alone and accounts for more than 50% of all DoD disabilities. These injuries often leave patients with permanent structural and functional deficits in the injured muscle and …
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Drive train improvements and performance evaluation of a robotically steered needle
… intended to robotically steer a thermal ablation electrode. The device is intended to enable more efficient kidney tumor ablation therapy guided by CT scanning. The steering mechanism is based on the concept of substantially straightening a pre-curved Nitinol stylet by retracting it into …
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Elucidating the Role of Pattern Recognition Receptors in Understanding, Treating, and Targeting Cancer
… induced colitis and colitis-associated tumorigenesis. We investigated whether the absence of NLRP1 in the gastrointestinal tract influenced the composition of the microbiome, and whether it was responsible for the predisposition of these animals to colitis-associated cancer. By carefully …
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The Potential of Cellulose Nanocrystals in the Detection and Treatment of Cancer
… CNCs' ability to potentiate a new technique for tumor ablation, IRE. Pre-incubation with FA-conjugated CNCs (CNC-FA) have shown an increase in cytotoxicity in FR-positive cancer cells induced by IRE. In addition, CNC-FA did not potentiate IRE-induced cytotoxicity in a FR-negative cancer cell …
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Non-linearity and Dispersion Effects in Tissue Impedance during Application of High Frequency Electroporation-Inducing Pulsed Electric Fields
… electroporation (IRE), a non-thermal tumor ablation modality, was investigated for safety and efficacy in clinical applications concerning different organs. IRE utilizes high voltage (~3kV), short duration (~100us) pulses to create transient nanoscale defects in the plasma membrane to …
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Investigations of Ultrasound-Guided Histotripsy Ablation for Soft Tissue Sarcomas, Osteosarcomas, and Brain Tumors
… investigated for superficial musculoskeletal tumor ablation. Additionally, preliminary investigations using histotripsy to ablate brain tumors are underway, but require advanced histotripsy devices capable of overcoming attenuation of the therapeutic ultrasound signal by the skull and rely on …
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Novel Approaches in Pancreatic Cancer Treatment: Bridging Mechanics, Cells, and Immunity
… that combine non-thermal, minimally invasive ablation technology and targeted drug delivery to enhance treatment efficacy. Our research begins by uncovering the multifaceted potential of Irreversible Electroporation (IRE), a cutting-edge non-thermal tumor ablation technique. This study …
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Investigating the ablative and immunomodulatory effects of high frequency irreversible electroporation on osteosarcoma in-vitro
Osteosarcoma (OS) is the most common primary bone tumor with an annual incidence rate of 3-4 individuals per million particularly affecting children and young adults. The 5-year survival rate stands at 60-80% with the current standard of care for human OS patients who do not have metastatic disease …
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Modeling of carbonization and stalling during radiofrequency ablation and electrosurgery
… (RF) thermal therapies, including RF ablation and electrosurgery, function by delivering alternating currents in the 100 kHz-1 MHz range to biological tissues. These currents generate electric fields that drive ionic oscillations in intracellular and extracellular fluids, producing …
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First-In-DOg HISTotripsy for Intracranial Tumors Trial: The FIDOHIST Study
Objective: Brain tumors represent some of the most treatment refractory cancers, and there is a clinical need for additional treatments for these tumors. Domesticated dogs are the only other mammalian species which commonly develop spontaneous brain tumors, making them an ideal model for …
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DEVELOPMENT OF A GENERAL LETHAL CRITERION FOR IRREVERSIBLE ELECTROPORATION
… is a non-thermal and promising technique for tumor ablation that generates an ablation zone producing permanent nanopores in the membrane of cells, thus leading to cell death. The ablation zone is determined with a designed treatment plan, including a selection of electric pulse scheme (or …
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Investigation of Single-Cell and Blood-Brain Barrier Mechanics after Electroporation and in Primary Brain Cancers
… or where cell viability is undesirable (tumor ablation, cardiac ablation). Precise control of cell shape and orientation enabled by nanofiber scaffolds provides a convenient and expedient platform for investigating a wide variety of factors (morphological and experimental) on cell …
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