Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"tubulin dynamics"”.
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Regulation of Tubulin dynamics by the +Tip tracking protein Mal3
… via an interaction between the charged tails of tubulin and Mal3. Mal3 MT binding domain structure was solved by X-ray crystallography so that eventually it may be docked into a higher resolution electron microscopy map to provide a more precise structural insight on how Mal3 stabilizes the MT …
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Modulating protein-protein interactions : novel inhibitors of PDZ domains and tubulin dynamics
… for all living systems. The interactionsbetween tubulin dimers is already a broadly studied area, whereas the PDZ domaininteractions is a relatively recent area of study. The literature in these areas is reviewed.This research project designed and synthesised novel molecules which were capable …
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Design, synthesis, and biological evaluation of dihydronaphthalene and chalcone-based anticancer agents inspired by the natural product combretastatin A-4.
… as vascular disrupting agents (VDAs), affect the tubulin dynamics of endothelial cells lining tumor-associated blood vessels. Tubulin depolymerization causes the endothelial cells to change shape and detach from the vessel wall leading to vessel collapse, which ultimately results in tumor …
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NOVEL MICROTUBULE TARGETING AGENTS: SYNTHESIS AND STRUCTURAL DETERMINATION OF THEIR INTERACTIONS
… of Basel, is focused on the microtubules dynamics and its breakdown associated to neurodegenerative diseases. Microtubule-targeting agents constitute a large group of chemically diverse molecules that bind tubulin and perturb the stability and functions of microtubules. While …