Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1128 for “"tuberculosis"”.
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Mycobacterium tuberculosis ClpC1: A potential target for tuberculosis drug discovery
… displaying potent activity against Mycobacterium tuberculosis (MIC50=0.05-0.1N<M). This compound is active against multidrug resistant clinical isolates, implying a new target. A preliminary study to identify the putative target of this compound was carried out to elucidate its mechanism of …
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Mycobacterium tuberculosis metallomics
Tuberculosis (TB) remains a major global health challenge, compounded by the rise of drug-resistant Mycobacterium tuberculosis (Mtb) strains, which necessitate the development of novel therapies or improvement of existing ones. Nanotechnology has gained prominence in the biomedical field, yet its …
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Tuberculosis: The Opportunistic Disease
Tuberculosis is an ancient disease caused by one of the most virulent and fatal biological agents; Mycobacterium tuberculosis (M. tuberculosis). Active pulmonary tuberculosis (TB) infection, which was nearly eradicated a generation ago, started to reemerge in a concerning manner in the late 1980's …
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Studies of childhood tuberculosis
Includes abstract. Includes bibliographical references (leaves 200-218).
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Reactivation of persistant tuberculosis
Exposure to Mycobacterium tuberculosis results in clinical tuberculosis only in a small percentage of immunocompetent individuals. In most instances mycobacteria are controlled by the host immune system and survive in a dormant state within granuloma. lmmunosuppression, however, may result in …
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Addressing challenges in the treatment of tuberculosis and tuberculosis meningitis: a pharmacometric approach
Tuberculosis (TB) is the primary cause of death from a single infectious agent worldwide. During the coronavirus disease (COVID-19) pandemic, TB briefly fell to second place, but it has now regained its position as the top infectious killer. It is caused by Mycobacterium tuberculosis and mainly …
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Tenosinovitis infecciosa por Mycobacterium Tuberculosis
… de manifestación extrapulmonar del Mycobacterium tuberculosis, etiología que por su comportamiento clínico y paraclínico puede confundir al examinador retardando su proceso diagnóstico Este artículo presenta el caso de un paciente masculino de 63 años, diestro, cesante, sin antecedentes relevantes …
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Vertebral tuberculosis : a clinical study
(1) Tuberculosis of the spinal column is local evidence of pre- existing general infection. The influence of this conception on treatment is emphasised.
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Modelling the transmission of tuberculosis
Airborne infectious diseases, such as tuberculosis (TB), are spread by airborne infectious particles (viable particles with potential for TB infection) in exhaled air from infectious individuals in enclosed spaces. Exhaled air is the carrier of airborne infectious particles and carbon dioxide is …
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Gaucher Disease Protects Against Tuberculosis
… in particular conferring protection against tuberculosis. Here, using a zebrafish Gaucher disease model, I find that the mutation GBA1 N370S, predominant among Ashkenazi Jews, increases resistance to tuberculosis through the microbicidal activity of glucosylsphingosine in macrophage …
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Immunological analysis of pericardial tuberculosis
Pericardial tuberculosis (TB) offers a relevant human model to study TB at the site of disease and to determine the effect of HIV-1 infection. 96 Patients with pericardial TB were recruited into this study, 68 of whom were HIV-1 infected. Where clinically indicated, pericardiocentesis was performed …
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Outcome of Tuberculosis treatment in sputum positive patients after eight months of anti-tuberculosis therapy
… of the study was to find out the outcome of tuberculosis treatment in Sputum Positive Patients after eight months anti-tuberculosis treatment. Observation and literature review has shown that there has been an increase in the number of tuberculosis patients since 1980 .A large proportion of …
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Outcome of Tuberculosis treatment in sputum positive patients after eight months of anti-tuberculosis therapy
… of the study was to find out the outcome of tuberculosis treatment in Sputum Positive Patients after eight months anti-tuberculosis treatment. Observation and literature review has shown that there has been an increase in the number of tuberculosis patients since 1980 .A large proportion of …
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Optimal tuberculosis case-finding methodologies for field trials of new tuberculosis vaccines in young children
… case-finding strategies in field trials of new tuberculosis vaccines conducted in young children. To investigate case-finding and case detection methods for tuberculosis in tuberculosis field trials conducted in young children.
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Investigating permeation of anti-mycobacterial agents in Mycobacterium tuberculosis and M. tuberculosis-infected macrophages in vitro as a model for early stage tuberculosis drug discovery
Tuberculosis (TB) is the leading cause of death due to a single infectious disease and remains a major threat to global public health. The increasing emergence of multi-drug resistance to current anti-TB drugs, exacerbated by the long treatment duration, highlights the need for new effective …
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Isolation and characterisation of novel DNA aptamers against Mycobacterium tuberculosis biomarkers: new tools for tuberculosis diagnostics
Tuberculosis is a curable disease with an average treatment success rate of 86 %. Despite this, there were an estimated 1.5 million deaths due to tuberculosis in 2013, most of which occurred in low and middle income countries. In order to overcome tuberculosis in developing countries innovation in …
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