Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"tsetse fly"”.
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Microbial Genome Evolution Due to Multifaceted Symbiosis within the Tsetse Fly (Diptera: Glossinidae)
… host dependency and times of establishment. The tsetse fly (Diptera: Glossinidae) serves as a relatively simple model system to investigate evolutionary aspects of symbiosis, while also maintaining medical and agricultural significance as vectors of African trypanosomes. In addition to …
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A comparative genomics approach towards classifying immunity-related proteins in the tsetse fly
Tsetse flies (Glossina spp) are vectors of African trypanosome (Trypanosoma spp) parasites, causative agents of Human African trypanosomiasis (sleeping sickness) and Nagana in livestock. Research suggests that tsetse fly immunity factors are key determinants in the success and failure of infection …
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An evolutionary genomics approach towards analysis of genes implicated in transmission of trypanosomes between tsetse fly and mammalian host
… any of the three players,the human host, the tsetse fly vector and/or the parasite. The human genome has been deciphered and the genomes of several trypanosome species have been sequenced. Sequencing of additional neglected trypanosome species is in progress. The tsetse fly genome is currently …
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Some aspects of the behaviour,ecology and vectorial capacity of glossina brevipalpis newstead and other flies in the Luangwa valley of Zambia
… brevipalpis was not easy to catch with ordinary fly rounds, but with the use of an electric screen fly round, more of this fly were caught. The best sampling system for G. brevipalpis was found to be artificial refuges which worked better in the hot dry season from mid-August to mid-December. …
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Some aspects of the behaviour,ecology and vectorial capacity of glossina brevipalpis newstead and other flies in the Luangwa valley of Zambia
… brevipalpis was not easy to catch with ordinary fly rounds, but with the use of an electric screen fly round, more of this fly were caught. The best sampling system for G. brevipalpis was found to be artificial refuges which worked better in the hot dry season from mid-August to mid-December. …
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Prevalence of human African trypanosomiasis and its associated risk factors in Itezhi-tezhi district of Zambia.
… caused by trypanosomes which are transmitted by tsetse flies of the genus Glossina. This study aimed to determine the prevalence and risk factors of HAT in Itezhi-Tezhi (ITT) District of Zambia through active surveillance. Human infective trypanosomes have been demonstrated to be in circulation …
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VSG expression in African trypanosomes: Gene silencing, cell cycle and developmental control
… Africa that cycle between a mammal and tsetse fly vector. In the mammalian host, these parasites exist exclusively extracellularly. To evade the adaptive immune system, trypanosomes undergo antigenic variation of the variant surface glycoprotein (VSG) coat. The trypanosome genome …
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Seventy years of changes in riverine woodland cover: Responses to elephants and human legacy effects in Gonarezhou National Park, Zimbabwe
… in the late 1950s to prevent the spread of tsetse fly (a vector for African Sleeping Sickness). This study makes use of aerial photography and satellite imagery of the Runde River, and its confluence with the Save River, covering the period 1948 to 2018. Using supervised classification …
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Understanding the composition and function of the flagellar groove in bloodstream form Trypanosoma brucei
… and is transmitted by the bite of an infected tsetse fly. A characteristic feature of the bloodstream from of T. brucei is the flagellum, which is laterally attached to the side of the cell body and is not disassembled during the cell cycle. Instead, a new flagellum is formed alongside the old …
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Uncovering the Role of 5'-Nucleotidases in Pyrimidine Metabolism in Trypanosoma brucei
… at risk for contracting T. brucei through the tsetse fly vector, and infection is typically fatal if untreated. While recent interventions have reduced disease prevalence, current therapies are toxic or fail to target the substantial animal reservoir. A better understanding of parasite …
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A Pharmacological Strategy Against African Sleeping Sickness
… sleeping sickness, transmitted via the bite of a tsetse fly. If left untreated, the parasite ultimately crosses the blood-brain eventually leading to death. Currently there are 5 approved drugs used to treat it, each with toxic side effects and effective at specific disease stages. A more …
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The PUF proteins in Trypanosoma brucei
… as it cycles between the mammalian host and the tsetse fly vector. This adaptation is mediated by changes in trypanosome gene expression, which are mainly regulated at the post-transcriptional level. Proteins with an RNA-binding "Puf" domain are important for post-transcriptional control by …
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Examination and management of human African Trypanosomiasis propagation using geospatial techniques
… disease transmitted by the bite of the tsetse fly that results in high human morbidity and mortality. The propagation of the disease has been linked to environmental factors, and understanding the vector’s habitat is vital to its control. There is no HAT vaccine, but biological control …
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Novel mitochondrial metabolism in excavate protists
… to an insect host. Within the mid-gut of its tsetse fly vector, T. brucei replicates as a procyclic trypomastigote; these cells are readily cultured and can be subjected to genetic manipulation in the laboratory. Despite the complete genome sequence being available, there are still many novel …
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Limiting the northerly advance of Trypanosoma brucei rhodesiense in post conflict Uganda
… is a protozoal infection that is vectored by the tsetse fly. It is the aim of this thesis to review the impact of this large scale treatment programme in terms of animal health and human disease. The Stamp Out Sleeping Sickness (SOS) campaign was designed to target the cattle reservoir of T. b. …
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Synthesis of biologically active heterocyclic compounds
… Africa. It is transmitted to humans by the tsetse fly which carries the parasitic subspecies Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Any compounds synthesised would also be tested to assess their potential as anti-parasitic agents. Parker synthesised a range of …
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Ecology, Agriculture and Proletarianization : A study of the sinazongwe area in Gwembe Valley of the Southern Province of Zambia : 1900 to 1989
… will further examine the impact of tsetse fly on agricultural expansion and its effects on livestock. We will show that the tsetse control measures introduced after 1958 were so effective that the number of cattle increased in the Sinazongwe sub-district.However, this increase in the …
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Ecology, Agriculture and Proletarianization : A study of the sinazongwe area in Gwembe Valley of the Southern Province of Zambia : 1900 to 1989
… will further examine the impact of tsetse fly on agricultural expansion and its effects on livestock. We will show that the tsetse control measures introduced after 1958 were so effective that the number of cattle increased in the Sinazongwe sub-district.However, this increase in the …
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Characterisation of factors that regulate homologous recombination and antigenic variation in Trypanosoma brucei
… in sub-Saharan Africa and is transmitted by the tsetse fly vector. To evade the mammalian immune response, T. brucei utilises antigenic variation, which involves switches in the Variant Surface Glycoprotein (VSG) expressed on the cell surface. Such reactions can occur at very high rates (~10-3 …
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Spatial epidemiology of Rhodesian sleeping sickness in recently affected areas of central and eastern Uganda
The tsetse transmitted fatal disease of humans, sleeping sickness, is caused by two morphologically identical subspecies of the parasite T. brucei; T. b. rhodesiense and T. b. gambiense. Current distributions of the two forms of disease are not known to overlap in any area, and Uganda is the only …
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