Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"tryptophan metabolism"”.
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Nicotinic Acid and Tryptophan Metabolism in the Chick
Made available in DSpace on 2014-12-05T17:47:20Z (GMT). No. of bitstreams: 1 0010474.pdf: 3461934 bytes, checksum: b2bd54ead012d8a3b6a641499b30de51 (MD5) Previous issue date: 1954
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The Effect of Gonadal Steroids and Altered Tryptophan Metabolism on behaviour
Gonedal steroids have been shown to affect tryptophan metabolism in both brain and body, end are thus thought capable of altering the rate of 5-hydroxyptamine synthesis, end consequently, serotoninergic neuronal activity. Subsequent behavioural changes should result, and a primary aim of the …
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A Study of Tryptophan Metabolism in the Rat Using the Isotopic Tracer Technique
Made available in DSpace on 2014-12-05T19:36:59Z (GMT). No. of bitstreams: 1 5900512.pdf: 3702675 bytes, checksum: 94919820aec424ca8bfa3e53e3e6619c (MD5) Previous issue date: 1958
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Unravelling the role of tryptophan metabolism in the microbiota-gut-brain axis: focus on the effects of stress and exercise
… the hypothalamic-pituitary-adrenal axis and tryptophan metabolism. This crosstalk has been widely characterised following chronic stress, in stress-related disorders and gastrointestinal disorders comorbid with psychological distress. The acute transitory reaction to an acute stressor and the …
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TRYPTOPHAN-DERIVED MICROBIAL METABOLITES PROMOTE NKT22 PRO-TUMORIGENIC FUNCTIONS IN COLITIS ASSOCIATED COLORECTAL CANCER PATIENTS
… enrichment of Odoribacter, a bacterium linked to tryptophan metabolism. Metabolites from Odoribacter stimulated iNKT cells to produce IL-22 via AhR activation. Metabolomic analysis confirmed elevated tryptophan metabolites in Odoribacter supernatants, driving NKT22 differentiation in vitro and in …
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Stress and inflammation regulate the kynurenine pathway dioxygenases in a glia‐ and tissue‐specific manner
… glucocorticoid- and cytokine-inducible enzymes tryptophan and indoleamine 2,3-dioxygenases (DOs: Tdo2, Ido1 and Ido2). The DOs are rate-limiting for tryptophan metabolism by the Kynurenine Pathway. While accumulating evidence supports an interconnection between symptoms of depression and …
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A systems approach to determine how Toxoplasma gondii Infection causes neuropsychiatric disease
… of the brains of BALB/c mice. Notable changes to tryptophan, purine, arginine and carnitine metabolism were observed in infected mice.Congenitally infected and mice exposed to the maternal immune response to T. gondii, but not congenitally infected were found to have decreased mobility compared …
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The gut microbiota in depression
… behaviours, as well as alterations in tryptophan metabolism. Although we provide evidence that the gut microbiota is altered in depression and that this alteration could have a role in prominent features of depression, an interventional study based on targeting the gut microbiota in …
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The Current Role of Kynurenine Pathway Interventions in Oxidative Stress and Redox Homeostasis in the Context of Aging and Cancer
… kynurenine pathway –the main route to metabolize tryptophan in the cell– has emerged as a therapeutic target in several age-related diseases, including cancer. Intermediate metabolites in the kynurenine pathway have immunological and redox properties that have been associated with cancer …
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The neurodevelopmental impact of stress and inflammation during pregnancy: influence of the maternal microbiome and gut health
… markers, measures of gut permeability, and tryptophan metabolism. Exposure to serum from “high-stress” pregnant women reduced neurite length in partially differentiated SH-SY5Y cells. This potentially harmful effect was due in part to phosphorylation of NF-κB p65 through a TNFα-dependent …
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Investigation into the biochemical changes in Tourette Syndrome with a potential for pharmacological manipulation
… pathway, which accounts for over 95% of tryptophan metabolism. Two previous studies by this research group reported elevated plasma KYN in Tourette syndrome (TS) patients when compared with age and sex matched controls and another study showed that KYN potentiated 5-HT2A-mediated …
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The Gut Microbiome as a Novel Approach for Reversing Long-Term Inflammation and Accelerated Aging Across the Lifespan
… metabolomics measured alterations in tryptophan pathways.</p> <p><strong>Results</strong>: Aged mice displayed a distinct peripheral immune cell profile, characterized by an expanded population of CD11bhigh B cells that trigger pro-inflammatory responses in microglia. This phenotype …
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Cellular and Molecular Mechanisms of Immunoregulation In Vivo
… produced in response to arachidonic acid or tryptophan metabolism. However, the intracellular counter-regulatory signaling pathways that are triggered in response to their stimulation of cells are unclear. We report that both molecules inhibit the pro-inflammatory activities of DCs by …
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Assessment of potential antibacterial drug targets
… out by the Dstl.KynB is an important enzyme in tryptophan metabolism and predicted to be essential in Pseudomonas aeruginosa. The <i>B. anthracis</i>, <i>B. cenocepacia</i> and <i>P. aeruginosa</i> KynB structures showed an amidase fold not previously described, with a distinctive binuclear …
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Capillary electrophoresis instrumentation and applications for the analysis of neural systems
… and reducing background interference. Many tryptophan and tyrosine metabolites present in biological systems are amenable to LINF detection. An enhanced wavelength-resolved CE-LINF instrument was developed in an effort to take advantage of improvements in technology and electronics to …
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Using Fundamental Properties of Light to Investigate Photonic Effects in Condensed Matter and Biological Tissues
… electrons with optical techniques, tryptophan, an essential amino acid, is key to studying the interaction of light with biological tissues. I used label-free optical techniques to evaluate the relative tryptophan content in normal and diseased tissues. Fluorescent spectra from …
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The role of the immune system in Parkinson’s Disease: from neuropathology to treatment.
… antigen presentation cells) and not due to IDO-1/tryptophan metabolism, the production of immunoregulatory adenosine or expression of any of the tested co-inhibitory molecules, as has been reported for other PSC-derived products. Cytokine assays revealed some evidence of a T cell response to …
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Maternal stress signature and infant neurodevelopment: determining the beneficial effects of human milk oligosaccharides - an in vitro study
… factors in maternal blood and a shift in tryptophan metabolism from the serotonin pathway towards the kynurenine pathway which impacts key metabolites associated with neurodevelopment. All of these changes can have negative effects on placental and foetal brain development in utero. In …
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Bio-behavioural evaluation of efavirenz and Δ9-tetrahydrocannabinol alone and in combination in rats with respect to psychosis and anxiety
… assay (ELISA) kits. Moreover, plasma tryptophan and its kynurenine metabolites (kynurenine, kynurenic acid (KYNA) and quinolinic acid (QA)) were determined using high-performance liquid chromatography (HPLC). One-way and two-way analysis of variance (ANOVA) and Bonferroni post hoc …
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