Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"tryptophan hydroxylase"”.
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Transcriptional regulation of the human tryptophan hydroxylase gene
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Rapid Alterations in Rat Brain Tryptophan Hydroxylase Activity; Effects of Adrenal Steroids, Drugs and Stressors
<p>Tryptophan (TP) hydroxylase activity was measured using a modification of the method developed by Ichiyama et al. (1968). The distribution of the enzyme in the rat brain was determined and found to correlate with serotonin (5-HT) distribution. Bilateral adrenalectomy resulted in a decrease …
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Impact of genetic variability in the serotonin transporter, Tryptophan Hydroxylase-2, and Serotonin 2A Receptors on MDMA Use and Impulsivity
… involvement of specific 5-HT genes, including tryptophan hydroxylase-2 (TPH-2), 5-HT transporter (5-HTT), and 5-HT2A receptor (5-HT2AR) in the effects of MDMA is incompletely understood. Our initial study compared the prevalence of polymorphisms leading to reduced gene expression in those genes …
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Cocaine Dependence: The Role of Serotonin Genes In
… transporter, serotonin receptors 2A and 2C and tryptophan hydroxylase 1 and 2 (TPH1 and TPH2). We predicted that attentional bias and impulsivity would be higher in cocaine dependent individuals who had lower serotonin function. In the current study, we found a significant association between …
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The effect of genotype on attention bias in rhesus macaques, Macaca mulatta, as a welfare indicator.
… transporter (5-HTTLPR; short and long allele), tryptophan hydroxylase 2 (TPH2; short and long allele), monoamine oxidase A (MAOA; 5-, 6- and 7-repeat allele) and mu-opioid receptor (OPRM1; C and G allele). Additionally, sequencing was utilised to identify novel SNPs in the dopamine receptor D4 …
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Structural Determinants of Post-transcriptional Protein Regulation as Modulators of Monoamine Signaling
… well characterized in the regulation of tyrosine hydroxylase (TH), but little is known about the regulation of the closely related tryptophan hydroxylases. The recent discovery of the second isoform of tryptophan hydroxylase (TPH2) has brought renewed interest to this field as the majority of this …
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Characterisation of human enteroendocrine cells in organoid models
… cells (ECs), organoids with labelled tryptophan hydroxylase 1 expressing cells (TPH1-Venus) were established from human duodenum, ileum and rectum. Bulk RNA sequencing was performed on duodenal ECs, and considered in parallel with single cell RNA sequencing data of small intestinal …
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The impact of serotonergic and dopaminergic genetic variation on endophenotypes of emotional processing
… polymorphism which impacts the functioning of tryptophan hydroxylase 2 (TPH2), the rate limiting enzyme in the biosynthesis of serotonin, on interindividual differences in the startle response was investigated in three different age samples: children, young adults and older adults. There was a …
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Exploring the function and sensing mechanisms of human enteroendocrine cells using intestinal organoids
… L-cells, aromatic amino acids phenylalanine and tryptophan induce GIP release upon basolateral stimulation, but not apical, likely via activation of CaSR and GPR142. Surprisingly, we did not observe GIP secretion upon basolateral stimulation with FFAR1 agonist AM1638, while secretion of GLP-1 was …