Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"tryptophan depletion"”.
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Neural and Psychological Mechanisms of Oral Sensation
… taste transduction. Chapter 6 describes an acute tryptophan depletion (ATD) study that examined the peripheral and central effect of reduced 5-HT levels on taste perception. The primary findings highlight that tryptophan levels do not effect sweet, sour, salt and bitter taste detection ability. A …
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The identification and characterization of novel persistence genes in chlamydia trachomatis
… This enzyme converts free intracellular tryptophan to N-formylkynurenine. Tryptophan starvation induces C. trachomatis to enter a viable-but-nonculturable state termed persistence, which has been proposed to play a key role in chronic Chlamydial disease. To circumvent host induced …
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The effect of a tryptophan-depleted diet on voluntary exercise in mice
The essential amino acid tryptophan serves as the precursor to serotonin, a neurotransmitter which regulates hunger and satiety, promotes sleep, relieves depression, and is found in elevated levels following exercise. A quantitative deficit in serotonin or abnormality in its mode of action is …
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Combination of Oncolytic Adenoviruses, T-Cell Activation, and Blockade of Ido Metabolic Circuitry For The Treatment of Glioma
… IDO is an IFN inducible enzyme that catabolizes tryptophan resulting in diminished proliferation or apoptosis of surrounding effector T cells. Furthermore, kynurenine (Kyn), a tryptophan metabolite, induces T-cell differentiation into Tregs. Excess Kyn also activates carcinogenic transcription …
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Neurochemical modulation of affective and behavioural control: Models and applications for psychiatry
… that employed the dietary technique acute tryptophan depletion (ATD). ATD temporarily lowers serotonin synthesis and release by depleting its biosynthetic precursor tryptophan. Chapter 3 is a study of self-reported social emotion. ATD enhanced emotion in response to social injustice …
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Kynurenines in neurological disorders
… mechanisms involved have yet to be established. Tryptophan can be metabolised via this pathway to produce the neurotoxic N-methyl-D-aspartate (NMDA) receptor agonist, quinolinic acid (QUIN), and the direct generators of reactive oxygen species, 3-hydroxykynurenine (3HKYN) and 3-hydroxyanthranilic …
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Towards a cognitive neurobiology of brain-gut axis disorders
The past two decades have seen substantial gains in our understanding of the complex processes underlying disturbed brain-gut communication in disorders such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Despite a growing understanding of the neurobiology of brain-gut axis …