Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"trypanosome"”.
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Folate transport and drug resistance in the African Trypanosome
… and resistance of antifolate drugs in African trypanosomes with a specific focus on transport mechanisms. A media deficient in folate and thymidine was established which enabled the assessment of their modulation on antifolate in vitro potencies and also screen a small set of antifolate …
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Nitroaromatic pro-drug activation and resistance in the African trypanosome
Sleeping sickness, caused by Trypanosoma brucei, is a deadly disease that affects some of the poorest countries in sub-Saharan Africa. Although the disease prevalence is declining, strengthening of the current control efforts, including introduction of more adequate chemotherapeutic options, is …
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African Trypanosome Genes Specifically Required for Fitness <i>in vivo</i>
… loss of fitness in vivo. Analyses of African trypanosome biology are often carried out in HMI culture medium which is rich in nutrients and may not necessarily be representative of the environments encountered in vivo. We reasoned that parasites in vivo are likely to display increased …
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Tracking the In Vivo Dynamics of Antigenic Variation in the African Trypanosome
… diversity of expressed VSGs in any population of trypanosomes. Using VSG-seq, I monitored VSG expression dynamics in vivo during both acute and chronic mouse infections. My experiments revealed unexpected diversity within parasite populations, and the expression of as much as one-third of the …
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Proteomic, Bioinformatic and Functional Characterization of the Nuclear Pore Complex of the African Trypanosome
… analysis of the protein components of the trypanosome NPC. Towards this end, we used several biochemical and proteomic strategies to identify the proteins that associate with a preparation of enriched T. brucei NEs. Discerning authentic trypanosome Nups from the 859 proteins identified was …
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Structure of the trypanosome transferrin receptor and insights into ligand binding and therapeutic strategies
African trypanosomes are extracellular protozoan pathogens that have evolved a complex and sophisticated interface with hosts to acquire nutrients and protect against the host immune system. The variant surface glycoprotein (VSG) forms a dense and dynamic protective coat, which serves to defend …
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The evolution of immune genes in tsetse flies (Glossina) and insights into tsetse-symbiont-trypanosome interactions
… the Red Queen arms race and balancing section. Trypanosome infection rates were unexpectedly high (69.35%), consisting of mixed species infections. Advantageous Def variants were observed to reduce infection rates within samples, while an observable relationship between TLR2 and symbiont …
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Understanding Primate Immunity to African Trypanosomes Through the Characterization of Trypanosome Lytic Factor Formation and Function
<p>African trypanosomes cause an annual loss of over 1 billion USD due to their economic and agricultural burden in Sub-Saharan Africa. These parasites are unicellular, extracellular parasites, that infect humans, cattle, and other livestock. Humans and some non-human primates are protected against …
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Antigenic Variation and Telomere Structure in Trypanosoma brucei
… mechanism. Here, it is demonstrated that trypanosomes engineered to express two VSGs simultaneously from the same ES can multiply in cultures and infect animals normally. Mechanisms involved in the control ES-associated gene expression are thought to involve some kind of telomere position …
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Biological Studies on Various Strains of Trypanosoma Avium
… and to initiate work for a newer aspect of trypanosome study; the effects of radiation upon trypanosome growth in vitro.
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Characterising the bacterial microbiota of Phlebotomus and Glossina insects : vectors of parasitic diseases
… is believed to increase tsetse susceptibility to trypanosome infection, was sequenced and compared to an ancestor S. glossinidius strain (SgGMMB4). SgGMMC1* contained a single large 17 kb deletion as well as 57 small indels and SNPs resulting in 12 putatively pseudogenised genes, supporting the …
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Expression and behaviour of GPI-anchored surface proteins in trypanosomes
… and tissue spaces of vertebrate hosts. African trypanosome species have evolved a variant surface glycoprotein (VSG) coat which underpins a population survival strategy based on antigenic variation. However, the vast majority of trypanosome species do not use this strategy and our understanding …
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Growth regulation in the protozoan parasite Trypanosoma brucei: Evidence of tyrosine-specific protein kinase activity
… multiplication of the parasite and caused the trypanosomes to accumulate in the G2 or M phase of the cell cycle. An in vitro kinase assay demonstrated the presence of a kinase capable of phosphorylating an exogenous substrate at tyrosine, and genistein was able to reduce trypanosome-mediated …
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Epidemiological role of indigenous dogs in the transmission of animal and human African trypanosomiasis in Zambia: a case study of dogs from Mambwe District
… in dogs. However, recent studies have detected trypanosomes in Zambian dogs. As a follow-up, the current research was designed to investigate what communities know about tsetse flies and AT and the role that dogs might play as trypanosome hosts. Data from the knowledge, attitudes, and practices …
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Published papers
… Northern Nigeria. • 4. On the Morphology of the Trypanosome (T. nigeriense, n. sp . ) from a Case of Sleeping Sickness from Eket, Southern Nigeria. • 5. On the Pathogenicity of the Trypanosome (T. nigeriense) from a Case of Sleeping Sickness from Eket, Southern Nigeria. • 6. Preliminary Note on …
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Discovery and development of diagnostic biomarkers for human African trypanosomiasis
… aim was to develop a lateral flow test based on trypanosome antigens. We used sera from <em>T. b. gambiense</em> infected and non-infected patients to identify infection specific diagnostic trypanosome proteins. The trypanosome proteins identified were then cloned into E. coli for recombinant …
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Molecular characterization of trypanosomes commonly found in cattle, wild animals and tsetse flies in Kwazulu-Natal, South Africa, 2005-2007
… (PCR and RFLP) to detect and characterize trypanosomes in cattle, wild animals and tsetse flies in KwaZulu-Natal, thus contributing to improved understanding of the genetic diversity of trypanosome species infecting cattle at the game/livestock interface in the KwaZulu-Natal Province of …
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Small molecule inhibitors of parasitic enzymes
… new and novel anti-trypanosomal inhibitors of trypanosome alternative oxidase, and (ii) synthetic and methodological studies.
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