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Showing 1 to 20 of 103 for “"troponin"”.
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Structure of Cocrystals of Tropomyosin and Troponin
… Contraction is initiated when calcium binds to troponin, causing it and tropomyosin to undergo conformational changes. Tropomyosin is an $\alpha$-helical protein with two chains (284 residues each) arranged as a coiled-coil. These rod-like molecules form cables wound in the grooves of the actin …
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Der Stellenwert der Troponin-I-(cTnl)- und Troponin-T-(cTnT)-Bestimmung in der Risikostratifizierung von Patienten mit akuter Lungenembolie
… bleibt eine Herausforderung. <br>Kardiales Troponin I (cTnI) und T (cTnT) sind zuverlässige Indikatoren für eine Schädigung des Myokards und können mit einer rechtsventrikulären Dysfunktion bei einer Lungenembolie assoziiert sein. <br>Methoden und Ergebnisse - Die vorliegende prospektive …
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Use of Troponin Testing after Non-cardiac Surgery
… guidelines recommending broad post-operative troponin surveillance in high-risk patients having major non-cardiac surgery. The objectives of this thesis were to: (1) evaluate the proportion of patients having major non-cardiac surgery in Ontario that would meet guideline recommendations for …
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A study of rat skeletal muscle Troponin C isoforms
… by an overall interest in the phenomenon of Troponin C (TnC) polymorphism in mammalian skeletal muscle. Gaining insights into this area of inquiry has been limited, in large part due to methodological problems associated with the identification of rat (a commonly used animal model for …
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Contribution of troponin-I to the regulation of cardiac muscle
Troponin-I (TnI) is one of the three components that makes up the troponin complex, which along with tropomyosin regulates striated muscle contraction. The cardiac isoform of TnI (cTnI) has a ~30 residue N-terminal extension, which contains two serines (Ser22/23) that become phosphorylated by …
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Erhöhung des hochsensitiven kardialen Troponin T bei Erkrankungen mit nicht-atherothrombotischer Myokardischämie
… Background: Elevated levels of high-sensitivity troponin T (hsTnT) indicate myocardial damage and can establish the diagnosis of acute coronary syndrome (ACS). However, also diseases without coronary artery occlusion can cause an elevated hsTnT, such as bradycardia, atrial fibrillation (AF), …
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Troponin-I-Freisetzung bei kardiochirurgischen Bypassoperationen mit und ohne Herz-Lungen-Maschine
In dieser Studie wurden der Troponin-I-Verlauf, sowie die Serumwerte von Myoglobin, CK und CK-MB prä- und postoperativ nach einem Bypasseingriff am Herzen untersucht. Die Patienten wurden entweder mit Hilfe der Herz-Lungen-Maschine oder im sogenannten Off-Pump-Verfahren operiert. Bei den Patienten …
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Thermodynamic Investigation into the Binding Properties of Cardiac Troponin (Human and Bovine)
Troponin is an integral protein in the mechanism of muscle contraction. In order to induce cardiac muscle contraction, Ca[superscript]2[superscript]+ must bind to the TnC subunit (calcium binding subunit) of troponin to begin a conformational change in the protein. The ATPase rate of myosin with …
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A FRET Investigation into Molecular Mechanisms of Cardiac Troponin Activation in Reconstituted Thin Filaments
… regulated by intracellular Ca2+ concentration. Troponin (Tn), the Ca2+-binding protein in muscle, allosterically regulates actin and myosin interactions (crossbridge formation) by facilitating the release of two troponin I (TnI) actin binding sites at high Ca2+, the inhibitory region (IR) and …
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A Novel accelerated diagnostic protocol to identify emergency department patients with chest pain who may be suitable for discharge after a single high-sensitivity troponin TRUST:Triage Rule-out Using high-sensitivity Troponin Chest Pain Study.
… for discharge after a single high-sensitivity troponin T (hs-cTnT) taken at presentation to the Emergency Department (ED). Comparison of the diagnostic accuracy of this ADP with strategies utilising initial undetectable hs-cTnT was made. Methods This prospective observational study evaluated …
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Versatile Aspects of Cardiac Troponin Assessment: Innovative Clinical Settings, Coronary Sinus Sampling, and Qualitative Laboratory Analyses
Contains fulltext : 249042.pdf (Publisher’s version ) (Open Access)
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A descriptive study of the use of troponin I testing at a Cape Town district hospital
Introduction: Troponin I tests have been shown to be accurate and are relied upon to assist in making critical decisions regarding patient care in patients presenting with chest pain. The tests are expensive, however, and so their rational use becomes extremely important in a budget-constrained …
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Evaluierung der Troponin-I-Freisetzung in der kardialen Lymphe bei herzchirurgischen Eingriffen unter Einsatz des extrakorporalen Kreislaufes
Extracorporeal circulation (ECC) induces a systemic inflammatory response and a perioperative myocardial damage (PMD) leading to postoperative myocardial dysfunction. The cardiac lymphatic system is because of its origin in the interstitial space of the heart, more sensitive than arterial and …
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Structural Characterization of the Amino- and Carboxy -Terminal Domains of Troponin C by High Pressure Nuclear Magnetic Resonance
Our main research objective is to investigate the effects of high pressure on the structure, stability, and dynamics of proteins. The application of pressure provides a unique method to reversibly unfold proteins. Pressure is a gentler method of denaturation than other more traditional methods and …
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Development of Magnetic Nanoparticle-based Enrichment Techniques and Mass Spectrometry Methods for Quantification of the Clinical Biomarker Cardiac Troponin I
Human cardiac troponin I (cTnI) in serum is a well-known clinical biomarker for cardiac tissue damage and is used for diagnosing myocardial infarction. Unfortunately, commercial cTnI immunoassays from different manufacturers can produce significantly different measurement results for the same …
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