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Showing 1 to 5 of 5 for “"tropinone"”.
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Asymmetric Synthesis of 1,3-Amino Alcohols and Tropinone Derivatives From Enantiopure Sulfinimines
… syn and anti 1,3-amino alcohols as well as tropinone and tropane-containing derivatives using sulfinimines (N-sulfinyl imines) as precursors for acid-catalyzed cascade cyclizations. Chiral N-sulfinyl b-amino ketones derived from N-sulfinyl b-amino Weinreb amides, serve as novel and direct …
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Chemistry with chiral lithium amides: enantiotopic group and face-selective reactions
… the γ-alkylation reaction from β-keto esters of tropinone and the enantioselective aziridine formation from nortropinone is first reported. This opened two new paths to develop tropinone enolate chemistry. One is indirect α-alkylation of tropinone, another is the nucleophilic attack from α-C …
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Towards the synthesis of hyacinthacines
The organocatalytic aldol reaction of tropinone with benzaldehyde using (S)-5-pyrrolidin-2-yl-1H-tetrazole as organocatalyst is described and it results in the formation of the dehydrated aldol adduct in moderate selectivity. The organocatalytic aldol reaction of CS and C2V-symmetrical dioxanones …
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Synthesis And Evaluation Of Novel Tropane Compounds As Potential Therapeutics For Drug Abuse
… derivatives were synthesized from 3-tropinone based on the structure of triple re-uptake inhibitor, DOV 216, 303. The compounds were designed as potential triple re-uptake inhibitors which could exhibit equipotent affinities at the monoamine transporters for dopamine, serotonin and …
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Development of Novel Nicotinic Receptor Mediated Therapeutic Agents: Synthesis and Biological Evaluation of Novel Epibatidine Analogs and the First Total Synthesis of Anabasamine and Related Analogs
… receptor. A stereoselective reduction of 2-tropinone led to the enantioselective synthesis of the desired acetoxytropane systems. These compounds were also tested in in vivo models for binding affinity and efficacy responses. Anabasamine, an alkaloid isolated from the Central Asian shrub, …