Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 101 for “"trophoblast"”.
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Physical Factors Regulating Human Trophoblast Invasion
… by inadequate invasion of extravillous trophoblast (EVT) cells into the uterine decidua. This invasion is necessary to transform the uterine arteries, ensuring an adequate maternal blood supply into the intervillous space for normal fetal growth and development. The mechanisms that …
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Acetyl-CoA metabolism and human trophoblast differentiation
Cytotrophoblasts are trophoblast stem cells that undergo rapid self-renewal and differentiation during early pregnancy. Disruptions in this process can lead to impaired placentation or placental dysfunction leading to complications in pregnancy. This thesis investigates the role of ATP citrate …
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Characterization of the endothelial cells response to trophoblast debris
… cells with normotensive and preeclamptic trophoblast debris, the largest class of placental extracellular vesicles. The investigations consisted of recognition mechanisms, changes in molecular phenotypes and cellular function of endothelial cells, with the aim of gaining a better …
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Endovascular trophoblast cell behavior in normal and abnormal pregnancy
… stimulating factor (M-CSF) on human trophoblast cells were examined. While term trophoblast cells did not respond to M-CSF, those from early trimester and choriocarcinoma cells showed enhanced growth after treatment. In addition, the serum level of M-CSF in hypertensive pregnant women …
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Development Of Trophoblast Lined Blood Spaces In The Mouse Placenta
Trophoblast giant cells (TGCs) have a unique ability to form pseudo-vascular spaces in the placenta. Proper development of these maternal blood spaces is crucial for successful pregnancy outcomes. Unlike blood vessels in other organs, the vascular space in placenta is line by non-endothelial TGCs. …
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Role of Endoplasmic Reticulum Stress in Trophoblast Stem Cell Differentiation
… reticulum (ER) stress on the differentiation of trophoblast stem cells (TSCs), placental development, and subsequent pregnancy outcome. To address this question, I first used an in vitro mouse TSC model. Morphological observations suggest that upon ER stress, TSCs lose stemness by differentiating …
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Poly (ADP-ribose) polymerase-1 (PARP-1) induces human trophoblast syncytialization
… the human placenta is comprised of cells termed trophoblasts and the proper differentiation of these cells is pivotal for maintaining maternal and fetal health throughout pregnancy. The placental syncytiotrophoblast layer is a key secretory portion of the placenta and is produced through fusion …
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Additive effects among uterine paracrine factors in promoting bovine trophoblast cell proliferation
… growth factor-1 (IGF1) promote bovine trophoblast cell proliferation, and to decipher the intracellular signaling mechanisms employed by these growth factors to regulate cell proliferation. Pilot studies established effective concentrations for each growth factor on a bovine trophoblast …
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Human trophoblast survival and invasion in the developing placenta: autocrine regulation by hbegf
… protein in early pregnancy that induces cytotrophoblast (CTB) cell differentiation to an invasive phenotype, protects against apoptosis, and is involved in an autocrine signaling mechanism that leads to its own protein synthesis. CTBs exist in a low O<sub>2</sub> environment during the first …
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Investigations of cellular stress-responsive proteins and PGF gene expression in human trophoblast
… these mechanisms occur in hypoxic stressed trophoblast and preeclamptic placenta. Methods: To determine transcript stability, PGF mRNA was measured in normal vs. stressed conditions, and the PGF 3'UTR was analyzed for consensus 3'AREs. To characterize stability regulation, the PGF 3'UTR was …
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Mode of Entry and Survival of Salmonella Enterica Serovar Typhimurium in Trophoblast Cells
… However, the susceptibility of human primary trophoblast cells (cTBCs) to Salmonella infection was not known. We hypothesized that human placental trophoblast cells are productively infected and provide a unique intracellular niche that permits uncontrolled Salmonella replication due to an …
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Biomaterial-based models of the endometrium and trophoblast invasion to investigate early pregnancy
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
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Trophoblast specification and differentiation potential in early human and non-human primate embryogenesis
Implantation is mediated by trophoblast, the outer layer of the early embryo. Trophoblast is an extraembryonic tissue that gives rise to the placenta, which sustains fetal growth and development. Human embryo implantation and early trophoblast development have remained elusive due to the …
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Role of Histone Lysine Demethylase, KDM1B, in Trophoblast Stem Cell Self-Renewal and Differentiation
… types. Reflecting this developmental plasticity, trophoblast stem cells (TSCs) can be derived from the TE of mouse blastocysts. TSCs have proven an invaluable research tool to study processes of early placentation in vitro. Despite the placenta’s central role in reproduction, our understanding of …
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The Impact of Excess Nutrients, Fatty Acids or Glucose, on BeWo Placental Trophoblast Metabolic Function
… The impacts of nutrient overabundance on BeWo trophoblasts (an in vitro model of both progenitor cytotrophoblasts and differentiated syncytiotrophoblasts) were specifically examined using functional readouts of cellular metabolism and mitochondrial respiration, measurements of nutrient storage, …
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Role of Activated Macrophages and Pro-Inflammatory Cytokines in Placental Trophoblast Invasion and Fetal Outcome
The invasion of trophoblast cells into the uterine wall is an essential component of normal human pregnancy. These trophoblast cells transform the uterine spiral arterioles into high-flow, low-resistance vessels that supply the placenta to support fetal growth and development. Inadequate …
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Expression and secretion of basigin by human placental trophoblast cells occurs via microvesicle shedding and is a regulated process
Successful pregnancy depends on the ability of trophoblast cells to invade into maternal uterine tissues in a tightly controlled manner. Subsequently the trophoblasts must remodel the uterine spiral arteries in order to establish an adequate blood supply for normal fetal and placental development. …
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The role of kisspeptin and its cognate receptor GPR54 in normal and abnormal placentation
Poor invasion of trophoblast cells in early pregnancy has been associated with preeclampsia and intrauterine growth restriction as well as other adverse pregnancy outcomes such as miscarriage, preterm birth and intrauterine death. Hypertensive disorders of pregnancy, including pre-eclampsia are one …
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