Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"trispecific"”.
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Engaging Immune Cells within the Tumor Microenvironment to Enhance Efficacy of Oncolytic Virotherapy
… two chimeric proteins, the Bispecific and Trispecific engagers (BiCEP and TriCEP), the genes encoding for which were delivered by an HSV amplicon system, packaged with the oncolytic virus as a helper virus. Oncolytic virotherapy can recruit NKG2D bearing NK or T cells to the tumor site, and …
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Evaluation of dynamic light scattering as a technique for the routine monitoring of therapeutic proteins on stability
… including monoclonal, bispecific and trispecific antibodies were tested, that varied in concentration from 2 mg/mL to 160 mg/mL. Multiple stressed samples were included in the test panel to explore the techniques’ ability to detect large particles and aggregates. The particle size and …
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NOVEL MONO-, BI- AND TRI-SPECIFIC IMMUNOMODULATORY ANTIBODIES FOR CANCER THERAPY AND TOOLS FOR OTHER THERAPEUTIC AND DIAGNOSTIC APPLICATIONS
Cancer represents one of the leading causes of death worldwide, and the development of novel immunotherapeutic strategies, such as that of immune checkpoint inhibitors (ICIs), has generated long-lasting responses in multiple malignancies. Even though safer than chemotherapies, some adverse events, …