Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"triptolide"”.
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PROTEOMICS INSIGHTS INTO MOLECULAR MECHANISMS OF TRIPTOLIDE AGAINST COLORECTAL CANCER
Triptolide, a diterpene triepoxide extracted from traditional Chinese medicinal plant, Leigongteng, has been shown to have strong anti-tumor activities. However, the molecular mechanisms of triptolide against colorectal cancer remains largely elusive to date. In my study, triptolide was …
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Towards a Formal Total Synthesis of Triptolide Via a Gold-catalyzed Cyclization Cascade
… made towards a formal total synthesis of triptolide, a naturally occurring diterpenoid triepoxide molecule. Isolated from a Chinese vine, triptolide features some interesting structural characteristics and has demonstrated a broad range of interesting medicinal effects. It has demonstrated …
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Enhanced yield of medicinal products from Tripterygium cell cultures
… acid (C). Yield improvement for the triptolide family of diterpenes (triptolide and tripdiolide) was approached through the synthesis of potential intermediates of the natural biosynthetic pathways, the first step in a technique where synthetic elaborations would be completed by cell …
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Development of circulating microRNA in drug-induced liver injury: studies in humans and zebrafish
… with regard to liver injury. A new drug, triptolide, originating from traditional Chinese medicine and responsible for DILI in China, was tested as an alternative model for drug-induced liver injury in zebrafish larvae. miRNA-122-5p decreased in zebrafish larvae after triptolide treatment …
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Investigating the interactions of G-quadruplexes with transcription and chromatin structure
… 1-ß-D-ribofuranoside and triptolide respectively. Using G4 ChIP-seq, it was found that promoter G4 formation was not diminished upon transcriptional inhibition, refuting the dogma that folding of promoter G4s depends on transcriptional activity. Since endogenous G4s form …
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Nuclear Factor Kappa B Pathway and human cancer therapeutics
… Disulfiram (DS), and anti-inflammatory drug, triptolide (PG490), markedly enhanced the cytotoxicity of several conventional anti-cancer drugs in colon, lung and breast cancer cell lines. PG490 induced caspase-dependent cell death accompanied by a significant decrease in Bcl-2 levels. PG490 …
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Understanding the relationship between large-scale chromatin structure and gene expression
… which inhibits transcription elongation, or triptolide, which inhibits transcription initiation, estrogen stimulation still caused cytological decompaction of the TFF1 locus, though the decompaction was delayed. The delay suggests transcription does play a role in large-scale chromatin …