Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 62 for “"triple helix"”.
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Specificity of triple helix formation
Triplex-forming oligonucleotides (TFOs) have been the subject of extensive<br/>research in recent years. They have potential applications in many areas; such as<br/>gene-based therapies, site-directed mutation and as biochemical tools. However,<br/>triplex technology has been hampered by several …
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The Barriers and Enablers in "Operationalising" the Triple Helix Model for Innovation
The Triple Helix model, which emphasises collaboration between academia, industry, and government, has gained significant attention as a framework for fostering innovation and economic development. This model has proven instrumental in assisting countries worldwide in formulating and implementing …
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Depletion induced bundling of rod-like colloids and simulations of triple helix bundles
… analyze the unexpected experimental behaviour of triple helix bundles folding through a nanopore. We ran coarse grained molecular dynamics simulations of 3HB to gain insight into the translocation process, and into the potential causes of the unexpected folding behaviour.
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Competition between the purine and pyrimidine triple helix motifs in an oligonucleotide system
Triple helices are classified into two groups according to the composition and orientation of the third strand, namely the pyrimidine motif and the purine motif. These motifs constitute two separate fields of research. It was proposed, based on the alternative design rules, that the two motifs can …
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Transient collagen triple-helix binding to membrane type 1 matrix metalloproteinase : interaction studies and NMR-guided structural docking
… and hemopexin domain and a collagen-I-mimicking Triple-Helical Peptide (THP). In this study, backbone chemical shifts were assigned for isolated MMP-14 catalytic and hemopexin domains. The results from gel-filtration chromatography, DLS and NMR combined suggested that MMP-14 hemopexin domain …
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Triple Helix Relations in Local and International Scientific Collaborations: A Case Study of Thailand, the United States, and China
… ecosystems. This study examines the dynamics of Triple Helix Relations, focusing on collaborations within Thailand and its international partnerships with the United States and China from 2006 to 2022. I use Shannon's mutual information, enhanced by Loet Leydesdorff, to analyze the synergy among …
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Triple Helix Model of Innovation for Renewable Energy Development in a Developing Economy: A case of the Nigerian Power Sector
… sustainable development goal (SDG) by 2030. The Triple-helix model of innovation involving government, universities, and Industry collaboration for innovation in many fields has provided a framework for joint action to innovate and offer solutions to modern-day challenges. This study examines …
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The implementation of the triple helix model of industry-university-government relations in Puerto Rico to promote knowledge-based regional economic development
… the government, and academia. Henry Etzkowitz's triple helix model of university-industry-government relations explains the synergies and organizational infrastructure needed to ensure a sustainable economic growth based on technology and innovation. This thesis focuses on the two initiatives in …
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Part I. Isoindolin-1-One Receptors for CG Base Pairs in a DNA Triple Helix. Part II. Cross-Linked Dendrimer Hosts Containing Reporter Groups for Amine Guests
RCM of the dendrimer followed by hydrolysis created a cross-linked host, which was used in UV/Vis titrations. These studies showed that the dendritic hosts binds unbranched diamines 53 to 85-fold more tightly than it binds monoamines. Furthermore, an assay of the dendrimer with several amine and …
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Design of Collagen-Mimetic Peptides
… arrangement of the laterally associated collagen triple helices – the structural unit of collagen – to form long, smooth fibrils with a characteristic 67 nm axial structural feature known as the <em>D-periodicity</em>.</p> <p>The fibrillogenesis of collagen in tissues is a complex process …
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Design, Structure and Applications of Collagen-Mimetic Peptides
The collagen triple helix is a unique protein fold found in all domains of life where is has diverse roles from imparting structure and strength to tissue, to initiating an immune response. While many factors affecting the structure and stability of the triple helix have previously been elucidated, …
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MODELO DE GESTÃO PARA INCUBADORA DE EMPRESAS SOB A PERSPECTIVA DE METODOLOGIAS DE GESTÃO APOIADAS EM REDE: O CASO DA INCUBADORA DE EMPRESAS DE BASE TECNOLÓGICA DA UNIVERSIDADE FEDERAL FLUMINENSE
… perspective of management methods supported on Triple Helix network, and also using some Balanced Scorecard elements. It ends to show the Incubator career, goal and specific setting, starting from the articulation of inside (academic community) and outside partnerships with several innovation …
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What factors determine the success and failure of innovation in China? A systemic study of the Chinese mining industry
… outcome of a System. This research adopts the Triple Helix approach to organise interviews and conduct fieldwork. This approach focuses upon the interaction of universities, governments and industries. The Innovation Ecosystem is also utilised to produce systemic research results. The empirical …
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I. Collagen-like polypeptides. II. Helix-turn-helix peptides and turn mimetics
… mammals. It consists of three left-handed PPII helixes coiled along a common axis to form a very compact right-handed super helix. The primary structure is shown to be (Gly-Xaa-Yaa)n repeats with high content of prolyl residues at both Xaa and Yaa positions. <i>Cis-trans</i> isomerization of the …
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Isomerization-Locked Alkene Analogues of Xaa–Pro Dipeptides in the Proteins Collagen and Bora
… human proteins. It exists as a right-handed superhelix called the triple helix. The triple helix consists of three left-handed polyproline type II (PPII helices) that intertwine around a common axis. Each PPII helix has the repeating peptide sequence (Gly–Xaa–Yaa)n with a high content of …
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Scientific research and economic activity : the perceptions of academic and industrial scientists of the production and capitalization of knowledge
… has been described by sociologists as the triple helix. As an analytical and normative concept, the triple helix is derived from the changing role of government in different societies in relation to academia and industry. Its basis is the recognition that the interaction among …
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Development of Collagen Mimetic Mini-Fibrils with Tunable Collagenase Susceptibility
… sequences, first form the rod-shaped collagen triple helix. These triple helices further self-assemble laterally in a specific manner to form fibrils having the characteristic 67 nm axially repeating structure known as the D-period. Enzymatic digestion of collagen fibrils by matrix …
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Small molecule-degrader conjugates for MALAT1 triplex degradation
… RNA sequence called MALAT1. Due to its uncommon triple helix structure, this transcript has a noteworthy stability, with a half-life of up to 15 hours, resulting in its build-up in the cell environment. This work details my efforts in the design and synthesis of efficient small molecule drugs …
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Examining the Role of the British Council's Creative Spark Programme in the Development of Enterprise and Entrepreneurship Education in Kazakhstan
… is demonstrated through the application of the Triple Helix model. <br/>The findings of this qualitative study indicate that although valuable and influential, the reach and effectiveness of the Creative Spark programme has been limited due to cultural factors, a lack of consistency and the …
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