Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"triphenylphosphonium"”.
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Targeted sensors for investigating mobile Zinc in biology
… Zinc Sensors to the Mitochondria Using Triphenylphosphonium Ions. Mitochondrial mobile zinc plays an important, although poorly understood, role in prostate cancer. To investigate the biology of zinc in the mitochondria, constructs incorporating fluorophores and the …
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Synthesis of 2H-1-Benzthiocin: a Precursor for the Generation of the "4n+2" Pi-electron 1-Benzthiocinide Anion.
… <strong>17</strong> which was converted to triphenylphosphonium bromide salt <strong>18</strong> in 75% yield. Wittig cyclization of <strong>18</strong> with K-t-BuO afforded 3,4-dihydro-2H-1-benzthiocin <strong>19</strong> in 71% yield. In an attempt to prepare 2H-1-benzthiocin …
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Synthesis and Biological Evaluation of Rigid Analogues of Methamphetamines
… via the ylides generated from the corresponding triphenylphosphonium benzylhalide salts. The substituted benzylazetidine analogs were synthesized from the corresponding benzylideneazetidienes via hydrogention over palladium and platinum catalysts. The benzylideneazetidine and benzyliazetidine …
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Analysis, Experimental Optimization and Chemical Synthesis of Cyclic Monomers Occurring in Edible Fats and Oils
… and $\omega$-carbomethoxyalkyl triphenylphosphonium bromides. The GC-retention features, the mass fragmentation pattern and the spectroscopic characteristics of the final synthetic products and intermediates were discussed in detail.
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Studies towards a total synthesis of Hippeastrine
… addition using (3-methoxycarbonylallyl)triphenylphosphonium bromide (94). The resulting cyclohexa-1,3-dienecarboxylic acid methyl ester (95) was complexed with Fe2(CO)9 to obtain tricarbonyl(cyclohexa-1,3-dienecarboxylic acid methyl ester)iron(0) (96) was converted into the highly …
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Synthesis of Inhibitors of Cystathionine β-Synthase
… inhibitor into the mitochondria. The use of the triphenylphosphonium cation should allow for the selective accumulation of AOA into the mitochondria due to the high inner membrane potential gradient. Modification of the carboxylic acid functionality of AOA to an ester and amide functionality will …
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Long-wavelength, reaction-based, fluorescent sensors for HNO and mobile zinc
… R9 peptide, the mitochondria-targeting triphenylphosphonium ion, and the DNA-binding Hoechst dye.
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Asymmetrische Totalsynthese von 13,14-Dinor-inter-p-phenylencarbacyclin mittels konjugierter 1,4-Addition an ein Azoen
… was carried out with (4-carboxybutyl)-triphenylphosphonium bromide / KOtBu in glyme. The protected prostacyclin analog was obtained in a E/Z-ratio of 72:28 in favour of the desired E-compound. Final deprotection of the hydroxy-groups delivered the target compound, the phenylogous …
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Chemical Strategies for Delivery of Compounds to Mitochondria
… approach is to attach the bioactive moiety to a triphenylphosphonium cation (TPP), which drives membrane potential-dependent uptake into the organelle. However, there are still limitations associated with TPP-targeting, some of which I have attempted to overcome in this work. Firstly, I have …
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Development and evaluation of fire retardent unsaturated polyester clay nanocomposites.
… novel PLSN formulations incorporating a range of triphenylphosphonium cations were encouraging but have, so far, only provided limited success.The Surefire resin system was estimated to be between 19 and 24% cheaper than brominated and chlorinated resins, while offering similar fire performance, …
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Regulation of the redox homeostasis during polyglutamine misfolding in Huntington’s Disease
… of MitoQ (Coenzyme Q10 covalently attached to triphenylphosphonium cation (TPP+)) at nanomolar concentrations abrogated the increased ROS due to mhttEx1 suggesting a mitochondrial origin of ROS.<br/><br/>Given that molecular chaperones regulate the folding/misfolding of proteins and are …
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Metal-organic frameworks as intracellular delivery vectors
… on mitochondria, and surface-functionalised with triphenylphosphonium, a known mitochondrial targeting agent. The system demonstrated a dramatic increase in efficacy, allowing a reduction in DCA effective dose of ca. 100-fold compared to the free drug, and ca. 10-fold compared to non-targeted, …