Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"trimethylene carbonate"”.
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Co-Delivery of Peptide QK and WKYMVm for Minimally Invasive Therapeutic Angiogenesis in Treating Critical Limb Ischemia
… liquid platform consisting of an aliphatic polycarbonate for the delivery of pro-angiogenic peptides QK and WKYMVm. The polymer bears pendant short-chain fatty acids (SCFAs) that have the potential to polarize M2 macrophages and modulate the immune response. The system is also degradable into …
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Load bearing regenerative repairs for the cartilaginous soft tissue of the intervertebral disc
… star-copolymers composed of D,L-lactide or trimethylene carbonate with caprolactone were mixed with an aqueous solution of methacrylated glycol chitosan to form a hydrogel-elastomer co-continuous morphology. After photo-cross-linking, the elastomer phase contributed the majority of the …
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Reversibly Photo-Crosslinkable Polycarbonate-Based Polymersomes for Drug Encapsulation and Delivery
… from poly(ethylene glycol)-block-polycarbonate (PEG-PC) copolymers functionalized with pendant coumarin groups. Coumarin groups undergo photo-reversible dimerization when irradiated with specific ultraviolet wavelengths, so they can be used to prepare polymers with photo-responsive …
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Self-assembled Polymeric Nanoparticles for Targeted Delivery of Anticancer Drugs
… biodegradable copolymer poly(2-methyl, 2-carboxy trimethylene carbonate-co-D,L-lactide)-graft-poly(ethylene glycol)-furan (poly(TMCC-co-LA)-g-PEG-furan) was synthesized and characterized. The copolymers self-assembled into spherical nanoparticles in aqueous environments with the hydrodynamic …
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Synthesis and performance of novel supramolecular tools for single-particle cryogenic electron microscopy and drug and gene delivery
… and guanidine bases. A library of mPEG-b-polycarbonate pendant polymers was synthesized and evaluated as part of a non-viral gene delivery system. The diblock copolymers showed the ability to form nanoparticles, typically 100-250 nm in size, with slightly positive surface zeta-potentials, …
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Development of P(TMC)-Based Polymers for Sustained Delivery of Acid-Sensitive Drugs
Peptides are a quickly growing drug class, which continue to garner attention in pharmaceutical research due to their applications in the treatment of a variety of diseases. The major challenge when working with these drugs is their rapid degradation in vivo and poor membrane-permeability. This …