Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"trimerization"”.
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The selective oligomerization of ethylene with metal-organic frameworks
… dimerization of ethylene and the selective trimerization of ethylene, which require fine steric and electronic tuning to optimize the production of the desired olefin. In this thesis, I describe the development of new heterogeneous catalysts to address the lack of activity and selectivity …
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INTEGRATED MOLECULAR INVESTIGATIONS OF MYRF AND SFRP2: UNVEILING REGULATORY MECHANISMS OF ER STRESS AND ECM REMODELLING IN PANCREATIC CANCER
… of pancreatic secretory glandular cells. After trimerization and self-cleavage, MYRF releases the N-terminal fragment which translocates into the nucleus to exert its transcriptional role by regulating the expression of genes encoding secretory proteins. However, the role of C-terminal fragment …
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Regulation of the Human Parainfluenza Virus (hPIV3) Fusion Protein
… However, in order to obtain the structure, a trimerization domain was used for structure stabilization. It is not known if the trimerization domain influenced the resulting crystal structure. My research has investigated the structure of the HRB region by creating mutations in both the …
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Structures and Reactivities of Ionized and Metal Cation-Containing Acetylene Clusters
… evidence for the frequently hypothesized trimerization of ionized acetylene to form the benzene ion. The results also provide evidence for the isomerization of the acetylene dimer ion, (C2H2)2+, to form the cyclobutadiene and vinylacetylene ions.Investigation of the reactions of acetylene …
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The crystal structure of human Navβ3-Ig domain and its implications
… not interfere with Na<sub>v</sub>β3-Ig domain trimerization. Independent evidence gathered using Analytical Ultracentrifugation (crosslinked, glycosylated Na<sub>v</sub>β3-Ig domain, *in vitro*), Proximity Ligation Assay (full-length Na<sub>v</sub>β3, *in vivo*), Atomic Force Microscopy …
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A. Discovery of novel reactivity under the Sonogashira reaction conditions B. Synthesis of functionalized BODIPYs and BODIPY-sugar conjugates
… conditions, terminal alkynes underwent self-trimerization or tetramerization. In an alternative approach to access substituted enediynes, treatment of alkynes with trisubstituted (Z)-bromoalkenyl-pinacolboronates under Sonogashira coupling conditions was found to give 1,2,4,6-tetrasubstituted …
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The Synthesis and Host-Guest Applications of Synthetic Receptor Molecules
… and the construction of CTV involves the cyclic trimerization of veratryl alcohol via the veratryl cation.3 Due to the rigid bowl shaped structure of CTV, CTV has been shown to act as a host molecule for fullerene-C60.4</p><p>Lectin binding receptor proteins are a specific class of proteins found …
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Stretching Collagen: Using Fluorophores in Collagen Mimetic Peptides as a Proposed Enantiomeric Sorting Technique
… are naturally chiral and can exhibit reversible trimerization, making them attractive platforms for development of adjunct therapies. This research aims to create two fluorescent naphthalimide isomers to be embedded within collagen mimetic peptides. These isomers are designed to act as walls of a …
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Anchoring Energy of Dengue E Protein into Host Membranes and Quaternary Assembly Depend upon Lipid Composition
… is necessary, sedimentation results suggest that trimerization occurred to a greater extent in the presence of anionic lipids. Taken together, our results reveal important functions of anionic lipids in facilitating membrane fusion useful for development of new therapeutic approaches.
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Directed Evolution of Glycan-Binding Proteins
… Fusion of the evolved GBPs to the coiled-coil trimerization domain of the lectin surfactant protein D (SP-D) leads to the formation of a trimeric GBP. These trimers are properly folded, stable, and have increased binding affinity compared to monomeric GBPs. Generation of trimeric Sso7d-based …
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Structural and biochemical characterization of LINC complexes
… have mapped the regions that are critical for trimerization. We believe that the best strategy moving forward is to structurally characterize the coiled-coil of SUN proteins, to which I have contributed important initial results. The cytoplasmic domains of KASH proteins, also known as Nesprins, …
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Molecular Interactions of Type III Secretion System Transcriptional Regulators in Pseudomonas aeruginosa: ExsA and ExsD
… protein was designed to demonstrate that ExsD trimerization prevents ExsD from inhibiting ExsA-dependent transcription at 30 degrees C. To further elucidate the ExsD-ExsA inhibitory mechanism, the ExsD-ExsA interface was examined. ExsD variants were generated and used to determine which region …
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Conformational engineering of human chemokine receptors and HIV-1 Env using deep mutational scanning
… trimers. Notably, the Env apical domain and trimerization interface are under selective pressure for PG16 binding. Based on this observation, mutations were found that increase presentation of quaternary epitopes associated with closed trimeric Env. Many of the mutations reduce electrostatic …
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Click Chemistry on DNA and Targeting RNA structure with Peptide Boronic Acids
… are laborious and confounded by boronic acid trimerization, which requires time consuming analysis of dehydration products. These issues are exacerbated when the peptide sequence is unknown, as with de novo sequencing, and especially when multiple boronic acid moieties are present. Thus, a …
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The Challenge of Selectivity in Ethylene Oligomerization: Ligand Design and Metal Valence States
Catalytic ethylene oligomerization is a well understood industrially viable process. The large majority of scientific literature and patents concerning this process has been developed with the use of chromium catalysts. Commercial systems producing selective tri/tetramerization, non-selective …
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Divalent transition metal centers: the synthesis of new chemical vapor deposition precursors and studies of ethylene polymerization and oligomerization catalysts
… H, or Cl, are catalysts for the dimerization and trimerization of ethylene (the latter generating only branched products). This work examines these systems at higher ethylene pressures and in the presence of an aluminum based co-catalyst. These titanium(II) compounds are active as polymerization …