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Showing 1 to 20 of 116 for “"trimer"”.

  1. Single chain MHC trimer-based DNA vaccines for pathogen protection

    Kim, Sojung2012

    … on the cell surface, termed single chain trimers: SCTs). SCTs are composed of an immunodominant peptide, β2m, and MHC I heavy chain covalently linked by 15-20 amino acid flexible linkers. Because SCTs are expressed as a single polypeptide chain, they do not require peptide processing, …

    wustl Repository record

  2. Refining the HIV-1 glycan shield model: dynamics of a heterogeneous envelope trimer and empirical prediction of glycan processing

    Garrard, ClareDepartment of Integrative Biomedical Sciences (IBMS)2019

    … of two computationally glycosylated HIV-1 Env trimers, one uniformly glycosylated, and the other based on the heterogeneous glycosylation of a laboratory determined gp160 strain. A secondary aim was to estimate whether the type of glycan is predictable using computational techniques, since …

    cape-town Repository record

  3. Dimers, Trimers and their Superpositions in a Bose-Fermi Mixture

    Chuang, AlexanderMassachusetts Institute of Technology2024

    … atoms. We examine the formation of dimers and trimers in a balanced, thermal mixture and their evolution into strongly interacting Bose polarons with hybridized dimer and trimer character when we instead immerse an impurity concentration of K into a dense quantum bath of Na. We report a novel …

    mit Repository record

  4. The crystal stucture determination of low and high temperature phases of Tris (Ethylene Terephthalate)

    Vyas, Ramesh HarakhjiUniversity of Central Lancashire1984

    … cell; d(obs) = 1.367 g/cm 3 . The HTP trimer crystals were formed from a hot solution of tris(ethylene terephthalate) and Dekalin above 1200C. These crystals were found to have a density of 1.321 g/cm 3 and a hexagonal unit cell of a = b = 15.37A ° , c = 20.78A° and y = 1200 ; Z = 6 …

    cent-lancashire Repository record

  5. Heterotrimeric coiled-coils as viral fusion protein mimics

    Johnson, Dana E., author, Kennan, Alan J., advisor, Finke, Richard G., committee member, Peersen, Olve B., committee member, Rovis, Tomislav, committee member, Shores, Matthew P., committee memberColorado State University. Libraries2010

    … viability of designing a self-assembling heterotrimeric coiled-coil by sole manipulation of the hydrophobic core. This technique utilized a steric matching approach whereby one large side chain packed against two small ones. An added benefit to this type of control is that it allowed the freedom …

    colostate Repository record

  6. Scanning Tunneling Microscopy Studies of Cluster Diffusion in a Highly Mismatched system:Copper on Silver(111)

    Signor, Andrew W.University of Illinois at Urbana-Champaign2015

    … and growth of Cu on Ag(111) reveal that trimers, once formed, have significantly higher mobilities than either atoms or dimers. While transient, this mobility makes trimers the dominant contributor to mass transport at temperatures allowing trimer formation (T ≥ 24 K). Using the STM …

    uiuc Repository record

  7. Scanning Tunneling Microscopy Studies of Cluster Diffusion in a Highly Mismatched System: Copper on Silver(111)

    Signor, Andrew W.University of Illinois at Urbana-Champaign2011

    … and growth of Cu on Ag(111) reveal that trimers, once formed, have significantly higher mobilities than either atoms or dimers. While transient, this mobility makes trimers the dominant contributor to mass transport at temperatures allowing trimer formation (T ≥ 24 K). Using the STM tip, …

    uiuc Repository record

  8. Aktivitätsregulierung der humanen DNS-Topoisomerase I durch den RNS-Spleißfaktor PSF/p54nrb

    Uhse, AnetteUniversität Würzburg

    … Hierbei wurde aus A431-Zellextrakten ein Trimer aus Topoisomerase I und zwei weiteren Proteinen koisoliert. Nach Identifizierung der zwei weiteren Proteine als Spleißfaktor PSF und dessen kleinerem Homolog, dem nukleären Protein p54nrb, wurden deren Auswirkungen auf die Aktivität der …

    wurz-thes Repository record

  9. Methods and Applications of Computational Design in Multiple States

    Dowling, Quinton Miles2023

    … to practical design problems; a peudosymmetric trimer used as a building block for assembling large, closed, cage-like nanostructures; and re-engineering a natural enzyme to remove allosteric dependence on double-stranded DNA for activity. In both cases I started by applying simple computational …

    washington Repository record

  10. Synthetic, Sulfated, Lignin-Based Anticoagulants

    Mehta, Akul2019

    … Our search identified a sulfated benzofuran trimer (a mimic of β-5 type linkage found in lignins) as a potent inhibitor of factor XIa. Surprisingly, this inhibitor did not compete with heparin. A plausible binding site in the A3 domain of factor XIa was proposed by using molecular modeling …

    vcu Repository record

  11. Neutralizing antibody responses in HIV dual infection: lessons for vaccine design

    Sheward, Daniel JamesDepartment of Clinical Laboratory Sciences2022

    … global health priority. Stabilized, soluble trimers that mimic the native functional HIV trimer have been developed that elicit strain-specific neutralizing HIV antibodies in animal models, and are currently being evaluated in several human clinical trials. Identifying whether multiple …

    cape-town Repository record

  12. Investigating self-assembly of linked oligomeric PPV-based materials

    Ingle, Shauna ElizabethThe University of Texas at Austin2014

    … altered amine and carboxylic acid alkoxy-linked trimer BEH-PPV in contrast to the bulky side chain tert-butyl trimer. The study of regio-regular (RR) and regio-random (RRa) alkoxy-linked pentamer poly(2-methoxy-5-(2’-ethylhexyloxy)-p-phenylenevinylene) (MEH-PPV) illustrates the limited effect of …

    texas Repository record

  13. STRUCTURE AND FUNCTION OF A NEURONAL GLUTAMATE TRANSPORTER

    Leary, Gregory Patrick

    <p>Glutamate transporters have a homotrimeric subunit structure with a large central water-filled cavity that extends partially into the plane of the lipid bilayer (Yernool et al., 2004). In addition to uptake of glutamate, the transporters also mediate a chloride conductance that is gated by Na+ …

    montana-tech Repository record

  14. STRUCTURE AND FUNCTION OF A NEURONAL GLUTAMATE TRANSPORTER

    Leary, Gregory Patrick

    <p>Glutamate transporters have a homotrimeric subunit structure with a large central water-filled cavity that extends partially into the plane of the lipid bilayer (Yernool et al., 2004). In addition to uptake of glutamate, the transporters also mediate a chloride conductance that is gated by Na+ …

    montana Repository record

  15. Automated Synthesis of Duplex-Forming Recognition-Encoded Oligomers

    Dhiman, MohitUniversity of Cambridge2023

    … by SPS. In the Hunter group, an oligotriazole trimer equipped with benzoic acid and phenol recognition units was previously replicated via covalent template-directed synthesis, but folding of the backbone led to significant side-reactions. Here, attempts were made towards a new, more rigid …

    cambridge Repository record

  16. Role of envelope compactness and glycosylation in HIV-1 resistance to neutralising antibody responses

    Moyo, ThandekaDivision of Immunology2017

    … before CD4-binding by destabilising the closed trimer structure. From these data, we hypothesized that the neutralisation resistance of 253-11 was due to an unusually tight, compact pre-fusion Env trimer that resists transient changes to the open conformation. The open conformation frequently …

    cape-town Repository record

  17. HIV entry : a biophysical and mutational analysis of gp41-mediated membrane fusion and its inhibition

    Suntoke, Tara RMassachusetts Institute of Technology2005

    … subunits, gpl20 and gp41, that associate as a trimer on the virion surface. Once gp 120 contacts the target cell, gp41 undergoes extensive conformational changes to mediate fusion of viral and cellular membranes. First, a short hydrophobic stretch of residues at the gp4 1 N-terminus insert into …

    mit Repository record

  18. An alum particle-based platform to enhance and investigate humoral immune responses to immunization

    Rodrigues, Kristen A.Massachusetts Institute of Technology2023

    … for a SARS-CoV-2 RBD antigen and an HIV envelope trimer MD39, systematically modulating characteristics of both the antigen and pSer linker to maximize on- target, vaccine relevant responses. These optimized pSer-antigen designs elicited robust antigen- specific germinal center B cell and serum …

    mit Repository record

  19. Molecular dynamics simulations of EMIM − BF4 ionic liquid for electrospray thrusters

    Azevedo, Victor AraujoUniversity of Illinois at Urbana-Champaign2022

    … occurs in the electrospray’s plume for dimer and trimer ionic species. In order to compare the all atom and the coarse grained model, bulk simulations were performed to replicate the properties and characteristics of the ionic liquid and validate the potentials selected. Then, the bulk systems …

    uiuc Repository record

  20. Computer Methods for Investigating Hydrogen-Bonded Equilibria in Alcohols

    Hossain, MD. Fokhray1998

    … monomer, closed cyclic and open chain dimers, trimers and tetramers. Ab initio calculations were carried out on these components using six basis sets up to the restricted Hartree Fock 6-31 l++G(3df,3pd) level. Relevant calculated infrared wavenumber and intensity values, O-H...O bond lengths …

    southwales Repository record

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