Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"trigeminal ganglia"”.
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Identification of Connexins in Facilitating Neuron-Satellite Glial Cell Signaling in Trigeminal Ganglia
Activation of trigeminal nerves in response to an inflammatory stimulus causes increased communication between neurons and surrounding satellite glial cells via gap junctions in the trigeminal ganglion (TG). The goal of this study was to identify the gap junction proteins, or connexins (Cxs), in …
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SEX DIFFERENCES IN GENE EXPRESSION AND PAIN-RELATED BEHAVIORS IN A PRECLINICAL MODEL OF MIGRAINE
… present in nociceptors, including those in the trigeminal ganglion that innervate cerebral vasculature. Previous work has shown that CGRP levels are increased in animal models of inflammatory pain and in the external jugular vein of humans during migraine attacks. The CGRP receptor is comprised …
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Transcriptiome analysis of a migraine model
… The transcriptome was characterized in the trigeminal ganglia and nucleus accumbens. Samples were sequenced using the Illumina HiSeq 4000 platform to produce paired end reads of 100 bp. Opalin, Slc32a, Cacna1b, and H2-Eb2 were among the 110 genes exhibiting significant interaction effects. …
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Effects of Single and Dual Orexin Receptor Antagonists on Trigeminal Nociception
… perception. This disorder is mediated by the trigeminal nerve, which provides sensory innervation to the face, scalp, and meninges. Migraine pain is conveyed to the brain via the trigeminothalamic tract, which relays nociceptive signaling from primary nociceptors to the hypothalamus. Orexins …
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Regulation of Neuropeptide Y, Vasoactive Intestinal Polypeptide, and Their Receptors in Trigeminal Ganglion Neurons and Glia in Response to Adjuvant-Induced Inflammation
<p>Activation of trigeminal nerves is involved in temporomandibular joint (TMJ) inflammation and pain transmission. Neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), and their receptors have been implicated in the underlying pathology of temporomandibular joint disorders. The goal of …
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Characterization of an in Vivo Model of Temporomandibular Joint Inflammation
Activation of trigeminal nerves is involved in temporomandibular joint (TMJ) inflamation and pain transmission. The proinflammatory molecule nitric oxide (NO) and protons are implicated in the underlying pathology of temporomandibular joint disorders. The goal of this study was to investigate gap …
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Differential regulation of herpes simplex virus-1 and herpes simplex virus-2 during latency and post reactivation in response to stress hormones and nerve trauma in primary adult sensory and sympathetic neurons
… only HSV-1 in sympathetic superior cervical ganglia (SCG) neurons, while HSV-2 was reactivated only by CORT in both sensory trigeminal ganglia (TG) neurons and sympathetic superior cervical (SCG) neurons. EPI utilized the combination of α and β adrenergic receptor complex, while CORT signaled …
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Estrogen Signaling in Trigeminal Nociception
… We used an established model of inflammatory trigeminal pain, injection of Complete Freund's adjuvant (CFA) into the masseter muscle, to determine whether ERK activation may play a role in hormone-related trigeminal pain disorders. We measured withdrawal responses to stimulation of the …
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Study of alternative splicing events associated with hyperalgesia
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01
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From Entry to Dysfunction: SARS-CoV-2 Neuropathogenesis in Peripheral Sensory and Autonomic Neurons and Its Implications
… symptoms observed in COVID-19, including trigeminal neuralgia, Horner syndrome, and radicular pain. These insights should inform future therapeutic strategies to mitigate the neurological sequelae of infection with SARS-CoV-2 as it transitions from a pandemic virus to endemicity.
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PURINERGIC TRANSMISSION IN MIGRAINE: ROLE OF P2Y RECEPTORS IN THE SPINAL-TRIGEMINAL SYSTEM IN VIVO AND IN VITRO
… of peripheral nociceptors. Indeed, the trigeminal nerve conveys sensory information from most extracranial and intracranial structures to the spinal trigeminal nucleus, and it has been therefore hypothesized that migraine could arise from a primary dysfunction leading to activation and …