Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 82 for “"trigeminal"”.
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Estrogen Signaling in Trigeminal Nociception
… We used an established model of inflammatory trigeminal pain, injection of Complete Freund's adjuvant (CFA) into the masseter muscle, to determine whether ERK activation may play a role in hormone-related trigeminal pain disorders. We measured withdrawal responses to stimulation of the …
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Secondary Traumatic Stress Promotes Peripheral Trigeminal Nociceptor Sensitization
… Sensitization and activation of peripheral trigeminal neurons that provide sensory innervation to most of the head and face is implicated in migraine pathology. The most commonly cited risk factor for migraine is stress, and in particular, primary traumatic stress directly to the individual. …
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THE ROLE OF TRIGEMINAL ISL1 NEURONS IN FEEDING BEHAVIOUR
… anatomical and functional characterization of trigeminal ISL1 neurons.
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Development of the Mesencephalic Trigeminal Nucleus in the Zebrafish
The mesencephalic trigeminal nucleus (MTN) forms part of the monosynaptic trigeminal circuit and is essential for eating and suckling in mammals. Little is known about how the MTN forms. For this thesis I aimed to elucidate the molecular and cellular basis of MTN development. I also aimed to …
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Voltage gated calcium channels – molecular targets for trigeminal neuralgia
Trigeminal neuralgia (TN) is a rare debilitating disease which is characterised by excruciating facial pain and has a higher incidence in women. Recent studies demonstrated that some TN patients present mutations in genes that encode different voltage-gated calcium channels, a class of ion channel …
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The Role of FGFR4 in Trigeminal Placode Cell Development
<p>In vertebrate embryos, the ophthalmic trigeminal (opV) placode contributes sensory neurons to the trigeminal ganglion during development of the peripheral nervous system. FGFR4 is expressed transiently in the trigeminal placode as cells undergo an epithelial-mesenchymal transition and begin to …
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Non-invasive measurement of trigeminal nerve somatosensory evoked potentials
… common yet enigmatic to substantiate clinically. Trigeminal somatosensory evoked potentials (TSEPs) were posited as an indicator of trigeminal nerve conduction damage resulting from whiplash. Alternating polarity square-wave current stimuli were applied transcutaneously in the facial region. 379 …
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THE RESPIRATORY RESPONSE OF TRPV1 KNOCKOUT MICE TO TRIGEMINAL IRRITANTS
The trigeminal nerve is composed of polymodal neurons which innervate the nasal cavity, nasopharynx, oral cavity and cornea. Trigeminal nociceptive fibers are stimulated by a wide variety of chemical irritants. However, the mechanism of stimulation is known for only a few compounds. TRPV1 channels, …
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Secondary Traumatic Stress Promotes Central Sensitization of the Trigeminal System
… peripheral and central sensitization of trigeminal nociceptive nerves. Since migraine is often comorbid with temporomandibular joint disorder and inflammatory bowel disease, it is associated with significant social and economic burdens. Primary traumatic stress is a significant risk …
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Calcitonin Gene-Related Peptide Promotes Peripheral and Central Trigeminal Sensitization
… by peripheral and central sensitization of trigeminal nociceptive neurons. Although CGRP is implicated in the development of central sensitization by stimulating glial activation via its receptor, the mechanism by which CGRP promotes and maintains sensitization of trigeminal nociceptive …
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Effects of Single and Dual Orexin Receptor Antagonists on Trigeminal Nociception
… perception. This disorder is mediated by the trigeminal nerve, which provides sensory innervation to the face, scalp, and meninges. Migraine pain is conveyed to the brain via the trigeminothalamic tract, which relays nociceptive signaling from primary nociceptors to the hypothalamus. Orexins …
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Effects of REM Sleep Deprivation on Trigeminal Nerves: Increased Thermal Sensitivity
… joint disorder. Sensitization and activation of trigeminal nerves, which provide sensory innervation to much of the head and face and mediate pain and inflammation, are implicated in the underlying pathology of these diseases. I hypothesized that sleep deprivation would cause sensitization of …
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The Role of Wnt Signaling in Development of the Ophthalmic Trigeminal Placode.
… system. The development of the ophthalmic trigeminal (opV) placode, which gives rise only to sensory neurons of the ophthalmic lobe of the trigeminal ganglion, is a well-studied model of sensory neuron development. While key differentiation processes have been characterized at the tissue …
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Hormonal Effects on Mechanoreceptor Function in the Trigeminal System of the Rat
Made available in DSpace on 2014-12-14T13:39:38Z (GMT). No. of bitstreams: 1 7708934.pdf: 5187089 bytes, checksum: 366cc98dd428d42172bee43e4e837855 (MD5) Previous issue date: 1976
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Identification of Connexins in Facilitating Neuron-Satellite Glial Cell Signaling in Trigeminal Ganglia
Activation of trigeminal nerves in response to an inflammatory stimulus causes increased communication between neurons and surrounding satellite glial cells via gap junctions in the trigeminal ganglion (TG). The goal of this study was to identify the gap junction proteins, or connexins (Cxs), in …
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IDENTIFICATION OF KEY MOLECULES IN PLACODE-DERIVED NEURONS THAT COORDINATE CHICK TRIGEMINAL GANGLIOGENESIS
The trigeminal nerve is the largest of the cranial nerves, possessing three main branches (ophthalmic, maxillary, and mandibular) and relaying sensations of pain, touch, and temperature from the face and head to the brain. Cell bodies of this nerve are positioned in the trigeminal ganglion, which …
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A Comparison of Personality Characteristics in Trigeminal Neuralgia and Atypical Facial Pain Using
PURPOSE: Trigeminal neuralgia and atypical facial pain are representative disease entities of chronic facial pain. Most patients of these disaeses could be accompanied with psychological, emotional problems as their pain become chronic. These diseases actually have many differences in …
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Topological organization of the trigeminal system in the lamprey and restoration following axonal regeneration
… existence of a topological organization of the trigeminal system in the lamprey. The purpose of the current study was two-fold: (1) confirm the topological organization of the trigeminal system in normal animals; and (2) determine if this organization is restored following trigeminal nerve …
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