Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"trifluoromethyl group"”.
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Solid-State NMR: investigations of biomolecular structure
… label and either a single fluorine or trifluoromethyl label. The distance between the phosphorous and fluorine(s) where measured using the heteronuclear REDOR experiment to determine enhancement of dipolar coupling due to a trifluoromethyl group as compared to a single fluorine group. …
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Development of Novel Methods for the Installation of Trifluoromethyl/Boryl and 1,2,4-Oxadiazole Moieties
There are immense efforts to install the trifluoromethyl group (CF3) into organic molecules since it significantly affects reactivity, as well as the biological and pharmaceutical properties of the molecule. The α-trifluoromethylacrylates are useful synthetic intermediates for the synthesis of …
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Synthesis of 4-(trifluoromethyl)azetidin-2-one building blocks and their transformation into novel CF3-substituted amines and heterocyclic systems
… on the other hand, β-lactams bearing a trifluoromethyl group comprise interesting entities for the construction of novel targets with promising bioactivities. In this PhD thesis, the preparation and deployment of 4-trifluoromethyl-β-lactams as new building blocks toward a diverse set of …
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Electronic absorption spectra of basic dyes containing terminal diethylamino and morpholino groups
… terms of the relative basicity of the terminal groups. Where substitution occurs in the meta- and para-positions of the phenyl ring, it has been shown that the wavelength of maximum absorption bears a linear relationship to the appropriate Hammett substitution constant. Observed,\ max values for …
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Ester-Based Synthetic Information Oligomers
… ester bonds and the ease of their synthesis. A trifluoromethyl group incorporated into the structure of D enhanced the strength of the hydrogen bonds and provided a convenient probe to study the association through $^{19}$F NMR spectroscopy. The strongly hydrogen-bonding recognition motifs were …
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Design and Synthesis of Orally Bioavailable Sphingosine Kinase 2 Selective Inhibitors
… first describe the discovery that introducing a trifluoromethyl group onto the internal aryl ring of our inhibitor scaffold led to superior selectivity and potency towards SphK2. We demonstrate that the trifluoromethyl moiety is interacting with a previously unknown side cavity in the substrate …
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Revisiting aryl N-methylcarbamate acetylcholinesterase inhibitors as potential insecticides to combat the malaria-transmitting mosquito, Anopheles gambiae
… to prepare 3-tert-alkylphenols wherein a methyl group was replaced by a trifluoromethyl group. Second, we adapted the methods of Tanaka to prepare 3-tert-alkylphenols that lack fluorine substitution. This method is competitive with the little known method of Reetz to convert aryl ketones to the …
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Antischistosomal structure-activity relationships of nitrated n-phenyl benzamide derivatives.
… Schistosoma mansoni adult worms attributed to trifluoromethyl group (CF3), an electron-withdrawing group. This study, therefore, sought to further enhance activity by nitrating the core-scaffold of the front-runner compound, MK1-11.The analogs of this compound were thus synthesized and tested …
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Antischistosomal structure-activity relationships of nitrated n-phenyl benzamide derivatives.
… Schistosoma mansoni adult worms attributed to trifluoromethyl group (CF3), an electron-withdrawing group. This study, therefore, sought to further enhance activity by nitrating the core-scaffold of the front-runner compound, MK1-11.The analogs of this compound were thus synthesized and tested …