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Showing 1 to 8 of 8 for “"trifluoperazine"”.
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Preparation and Characterization Of Oil-in-water Nano-emulsions Of Trifluoperazine For Parenteral Drug Delivery
… formulation of oil-in-water nano-emulsions of trifluoperazine for parenteral delivery. 2.) To perform short term stability testing of the optimal formulation and monitor the potency using high performance chromatography (HPLC).</p><p> Materials and Methods: Emulsions containing soybean oil, …
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K+-Induced Smooth Muscle Calcium Sensitization Requires RhoA Kinase (ROK) Translocation to Caveolae Which Is Inhibited in Non-Neuronal Cell Memory
… by nifedipine and the calmodulin blocker, trifluoperazine. Since, -30% of RhoA is colocalized with caveolin basally, these data suggest a novel model for Ca<sup>2+</sup>-activated Ca<sup>2+</sup>-sensitization, elicited by KC1 contraction, that involves Ca<sup>2</sup>+/cam dependent ROK …
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Studies on the role of the autonomic nervous system in airway hyperreactivity.
… and evoked tone. The calmodulin antagonist, trifluoperazine (TFP), also reduced responses to applied ACh and vagal stimulation in normal guinea-pigs. In sensitized trachea, verapamil was less effective against vagally-induced tone suggesting that changes in pre-junctional Ca2+ - channels are …
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Combating Plague: Fighting a War on Two Fronts Through Vaccine Design and New Therapeutic Intervention
… drugs, doxapram (DXP), amoxapine (AXPN), and trifluoperazine (TFP), increased animal survivability despite not exhibiting any direct bacteriostatic or bactericidal effect on Y. pestis in vitro and having no modulating effect on crucial Y. pestis virulence factors, suggesting that DXP, AXPN, …
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Manganese-stimulated protein phosphorylation in the rat pancreas.
… (1 to 10 μg/ml) significantly enhanced, whereas trifluoperazine (TFP) and Mg²⁺ inhibited Mn²⁺-stimulated p98 phosphorylation. Under the above incubation conditions, Mn²⁺-stimulated phosphorylation of p98 was also observed in isolated pancreatic acini, but not in cytosols from liver or kidney. …
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Age and Sex Related Behavioral Changes in Mice Congenitally Infected with Toxoplasma gondii: Role of dopamine and other neurotransmitters in the genesis of behavioral changes due to congenital infection and attempted amelioration with interferon gamma
… valproic acid, fluphenazine, thioridazine and trifluoperazine inhibited T. gondii development. The effects T. gondii infection had on behavior were examined using a congenital mouse model. Previous work demonstrated maternal immune stimulation (MIS) with interferon gamma (INF-g) resulted in …
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STUDIES ON A CALCIUM-DEPENDENT ACTIVATOR PROTEIN, STRUCTURALLY AND FUNCTIONALLY HOMOLOGOUS TO CALMODULIN, FROM THE WATER MOLD ACHLYA AMBISEXUALIS RAPER.
… growth of walls. Anti-calmodulin drugs such as trifluoperazine (TFP) inhibit Achlya CaM-dependent activation of bovine PDE, spore germination, germ tube growth, colony formation, sporangial induction and spore release, with the latter process being the most sensitive; growing hyphae are …
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A neutral protease of the neutrophil surface : role in the proteolysis of C-reactive protein and fibrinogen
… was achieved through activation of H7 and trifluoperazine inhibitable cellular kinases and changes in microfilament assembly. The generation of non-clottable fibrinogen together with possible modulation of neutrophil receptormediated functions by the fibringen degradation products as well …