Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"tridentate ligands"”.
-
Platinum Complexes With Tridentate Ligands as Models for Active Monofunctional Anticancer Drugs
… for monofunctional Pt(II) complexes with carrier ligands having bulk projecting toward the guanine base. This ligand bulk can be correlated with impeded rotation about the Pt–N7(guanine) bond. The objective of this study is to understand the influences of in-plane bulk of Pt(Ltri)G adducts (Ltri = …
-
Nondirected C(sp2)–H Activation of (Hetero-)Arenes Through Ligand-Enabled Palladium Catalysis
… of this thesis was the development of innovative ligands for Pd-catalyzed nondirected C–H activation, which enable new reactivities and transformations. The first chapter deals with the historical development of a palladium-based catalyst system consisting of two complementary ligands, which …
-
Exploring the binding of amine and sulfonamide ligands in Rhenium(I) Tricarbonyl and Platinum(II) complexes
… Several new Pt(II) complexes of polyamine ligands bearing a dansyl moiety linked by a sulfonamide group were prepared; in some cases the sulfonamide nitrogen formed a bond to Pt. The sulfonamido group donates strongly to Pt and places the dansyl group close to a vacant coordination …
-
The Synthesis and Characterization Of A Functionalized Diethylenetriamine Rhenium Complex Followed By Analytical Analysis of Novel Rhenium-Luteinizing Hormone-Releasing Hormone Conjugates
… [99mTc(CO)3L]+ core, when facially chelated by tridentate ligands, shows superior pharmacokinetics and stability. Given the nuclear characteristics of 99mTc, studying these complexes is complicated. Here we use non-radioactive rhenium (Re) in [Re(CO)3L]+ analogues to serve as safer models for …
-
Peptide Targeting of Platinum Anti-Cancer Drug and Synthesis of Water Soluble Monofunctional Pt(II) Complexes Useful for Biological Labeling
… only one reactive sight were synthesized. The tridentate ligands were characterized by X-ray crystallography, fluorescence and NMR spectroscopy. Interaction of platinum complexes and nucleotide (5¡ä-GMP) was monitored by NMR to reveal different rate of rotation about the Pt¨CN(7) bond depending …
-
Synthesis of cyclometalated gold (III) complexesfunctionalized by alkynyl derivatives. Study of the interaction with DNA secondary structures.
… gold(III) complexes functionalized by alkynyl ligands, as well as the study of the interaction of the studied complexes with DNA secondary structures. In this work, bidentate and tridentate ligands, in particular derived from both phenylpyridine and diphenylpyridine, respectively, have been …
-
Oxo-metal catalysed reactions of unsaturated alcohols
… of oxo-molybdenum complexes containing novel tridentate ligands derived from substituted salicylaldéhydes and chiral 2-aminoalcohols are also described along with a D(-)-2,3- butandiol complex of dioxomolybdeniam(VI ). As in a number of examples recently reported in the literature, epoxidation …
-
Synthetic Routes to 3-Fold Symmetric Tridentate Oxygen Donor Ligands
The class of ligands represented by [CpCo(P(O)(OR)2)3]-, L- , were first synthesized by W. Kläui in 1977. These ligands have been found to coordinate to a variety of low and high oxidation state metals through the use of its three P=O oxygen atoms as donors. The ligands act as mono-anionic six …
-
Unsymmetrical tridentate phosphine ligands
… the preparation of unsymmetrical triphosphine ligands, which necessarily contain one central chiral phosphorus atom. The ttparent" tridentate phosphine is (2- diphenylphosphinoethyl)(3-diphenylphosphinopropyl) phenylphosphine, Ph2P(CH2)3PPh(CH2)2PPh2, "eptp". Other tridentates were prepared by …
-
Activation Of Tumor Cell Death Program By Targeting The Ubiquitin-Proteasome Pathway: Significance In Cancer Treatment And Prevention
… We found that gallium-cotaining [NN'O] tridentate ligands appended with halogen substituents could inhibit the proteasomal activity in vitro and in human prostate cancer cells. Importantly, the most biologically active complex (5) could inhibit tumor growth in mice-bearing prostate …
-
Design and synthesis of new metallo-organic complexes and their evaluation as anti-cancer agents. Synthesis, characterisation and biological evaluation of novel, late first row transition metal schiff base complexes, as anti-cancer metallopharmaceuticals
… and understand the role of metal, chelating ligands and anionic ligands when carrying out their cytotoxic effect. This study has lead to a better understanding of the action of these classes of complex and will be used to direct the design of new anti-cancer metallopharmaceuticals going …