Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"trichomoniasis"”.
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Assay development for use in drug discovery against Bovine Trichomoniasis
<p>Bovine trichomoniasis is a venereal disease that affects cattle. The causative agent of this disease is <em>Tritrichomonas foetus</em>, a flagellated protozoan. There is no current FDA approved treatment for this disease. The purpose of this study was to develop new compound screening assays …
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Microarray analysis of Trichomonas vaginalis strains T1 and G3: Identifying genes that may contribute to virulence and metronidazole resistance
… for causing nearly eight million cases of Trichomoniasis every year in the United States. Trichomoniasis is often an asymptomatic infection, but in some cases it does lead to mild clinical manifestions. Trichomoniasis is easily treated with a single dose of Metronidazole. Drug resistance is …
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Expression and analysis of a legumain from trichomonas vaginalis
… are the etiologic agents of human and bovine trichomoniasis, respectively. As microaerophilic protozoans; both share a wide array of clinical manifestations ranging from vaginitis to abnormal pregnancies. Human trichomoniasis receives minimal public health attention despite of its worldwide …
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The characterization of cysteine protease 4 and superoxide dismutase 6 in Trichomonas vaginalis
… Trichomonas vaginalis , the causative agent of Trichomoniasis, is largely unknown although cysteine proteases have been implicated. This paper investigated the role of cysteine protease 4 (CP4) in T. vaginalis through characterization and expression of CP4. T. vaginalis strains showed …
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The interaction between HIV and other sexually transmitted infections in South Africa: a model-based evaluation
… chancroid, gonorrhoea, chlamydial infection and trichomoniasis), as well as the incidence of bacterial vaginosis and vaginal candidiasis in women. The model is fitted to national HIV prevalence survey data, STI prevalence data from sentinel surveys and data from sexual behaviour surveys, using …
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Analysis of a trichomonas vaginalis cysteine protease
<p>Trichomoniasis affects 170 million people worldwide, and 7.4 million in the USA. There is increasing focus on the role of cysteine proteases in Trichomonas vaginalis because of their role in virulence of other parasitic protozoa. Determining their location and function will provide insight about …
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Trashing old notions: the significance of small tRNAs in Trichomonas vaginalis extracellular vesicles and implications for host-parasite communication
Trichomoniasis is a common sexually transmitted infection caused by the protozoan Trichomonas vaginalis. Extracellular vesicles (EVs) released by this parasite have been shown to play a role in priming host cells for infection. However, the contribution of EV RNA cargo to the infection process …
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Characterization of subtilisin-like serine proteases in trichomonas vaginalis
… is the etiologic agent causing human trichomoniasis, a sexually transmitted infection found worldwide. In this study, subtilisin-like serine proteases (subtilases) were examined for their putative role in cell viability. Published data of other eukaryotic protozoan parasites confirm …
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Characterization of the DMCI and Rad51 homologues and the process of meiosis in trichomonas vaginalis
… vaginal is is the sexually transmitted agent of trichomoniasis. Although the organism is believed to only reproduce via binary fission, genes specific to 5 Meiosis and Homologous Recombination have been identified in its genome. It is unclear whether the organism has the ability to undergo sexual …
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Compound discovery and expression of a putative cathepsin D-like protease in Trichomonas vaginalis
… that is the causative agent in the disease trichomoniasis. Resistance to the only FDA-approved medication to this disease, metronidazole, has been on the increase giving rise to the need for finding targets for new inhibitors to exploit. New inhibitors can target enzymes such as …
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Inducible immunity to Trichomonas vaginalis in a mouse model of vaginal infection.
… causes a common sexually transmitted disease, trichomoniasis. Despite its high prevalance, the pathogenesis and immunogenicity of T. vaginalis are not well understood. Because currently available therapies are not always effective in treatment or in disease control and because of the impact of …
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Biochemical analysis of a potential drug target in the human protozoal pathogen Trichomonas vaginalis
… oxioreductase and ferredoxin, to treat trichomoniasis caused by T. vaginalis. Recent studies have shown alternative pathways responsible for activating metronidazole without the involvement of hydrogenosomal enzymes. This pathway requires the participation of thioredoxin and thioredoxin …
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The role of TvTrxR in drug resistance and characterization of TvRad51 in homologous recombination in Trichomonas vaginalis
… auranofin is a promising agent for treatment of trichomoniasis. Another aspect of T. vaginalis biology addressed in this study is the ability of T. vaginalis to carry out homologous recombination (HR), a process used to repair double-stranded breaks in DNA. The protein radiation sensitive protein …
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Identification and molecular characterisation of a putative gene for cell detaching factor from Trichomonas vaginalis.
… vaginalis (Tv) is the etiologic agent of trichomoniasis, a sexually transmitted disease of significant socio-economic importance. Cell-free filtrate from Tv growth media causes rounding and detachment of adherent monolayers of human epithelial cells in culture. Cell detaching factor (CDF), …
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A Survey of the Microflora Obtained by Flushing the Normal Bovine Uterus
… organisms as those causing brucellosis and trichomoniasis has been known for some time. Whether or not other contamination organisms placed in the uterus by seemingly sterile instruments will reduce fertility, increase abortions, or cause permanent sterility has not been established. In …
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Tiny Can Be Big: The Contribution of Microbial Extracellular Vesicles to Host-Pathogen Interactions
… flagellated protozoan is a causative agent of trichomoniasis, one of the world’s most common non-viral sexually transmitted infections. The co-existence of these pro- and eukaryotic microorganisms (i.e. bacteria and protozoan) in the vagina, as revealed by metagenomics, suggests a functional …
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Efforts to elucidate functional and regulatory aspects of gene expression in Trichomonas vaginalis
… resides in the human urogenital tract causing trichomoniasis, a sexually transmitted infection worldwide. It is also an organism of interest for studying the early evolution of eukaryotes. Despite its medical and academic importance, the T. vaginalis genome, published over a decade ago, remains …