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Showing 1 to 4 of 4 for “"triazolopyrimidine"”.
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Characterization and Management of Acetolactate Synthase Inhibiting Herbicide Resistant Mouse-Ear Cress (Arabidopsis thaliana) in Winter Wheat
… evolved cross-resistance to sulfonylureas (SU), triazolopyrimidine sulfonanilides (TP), and sulfonylaminocarbonyltriazolinones (SCT). Further studies sequenced the whole genome for four field populations, representing two locations and two resistance levels (high and low) per location, to …
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Metabolomic Approaches in Parasitology
… for malaria through clinical studies on the triazolopyrimidine-based Plasmodium DHODH inhibitor DSM265. Selective toxicity towards Plasmodium species could be achieved because malaria parasites lack pyrimidine salvage pathways, and DSM265 selectively inhibits Plasmodium DHODH over the human …
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Characterization of Acetolactate Synthase-Inhibiting Herbicide-Resistant Smooth Pigweed and Corn Weed Management Programs Utilizing Mesotrione in Combinations with Other Herbicides
… (SU), pyrimidinylthiobenzoate (PTB), and triazolopyrimidine sulfonanilide (TP) chemistries. Transformation of this smooth pigweed ALS gene into <i>Arabidopsis thaliana</i> confirmed that the Asp<sub>376</sub> substitution is responsible for the resistance. Other biotypes that had a …
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Elaboration of 4′-Phosphopantetheine Adenylyltransferase inhibitors and Benzoxaboroles as antimalarial agents
… by Novartis were explored, and a similar triazolopyrimidine series resulted in a hit compound 28/MM2-145 with PfNF54 IC50 = 2.2 µM. Formal hit assessment study of this compound with the SAR strategy proposed in Figure 2 resulted in compounds with low antiplasmodium activity. The Ugi series …