Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"triazoles"”.
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JULIA-KOCIENSKI APPROACH TO 4-SUBSTITUTED 1- ALKENYL-1H-1,2,3-TRIAZOLES
… to the synthesis of 4-substituted N-vinyltriazoles was<br />developed. The triazole cores were assembled by copper-catalyzed 1,3-dipolar<br />cycloaddition of 1-phenyl-1H-tetrazol-5-yl (PT) azidomethyl sulfide with: pmethoxyphenyl, 2-pyridyl, and triisopropylsilyl alkynes. Subsequent …
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Pleuromutilin and its Application Towards Bidentate Antibiotics: Triazoles, Linker Chemistry, and Serendipitous Discoveries
The world is facing a global antimicrobial-resistance (AMR) crisis. Classes of antibiotics continually face ineffectiveness as resistance mechanisms in microbes develop and propagate. The semi-synthetic derivatization of natural product antibiotics has provided many of our treatments, but new …
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Studies With Triazoles to Alleviate Drought Stress in GreenHouse-Grown Maize (Zea mays) Seedlings
… physiological parameters. Applications of three triazoles (paclobutrazol, uniconazole and tetraconazole) altered morphology and physiology in ways that might impart drought resistance. Paclobutrazol and uniconazole increased root:shoot ratio in laboratory studies and in the greenhouse. When …
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1,2,3-triazoles as X-factor in gold(I) activation of challenging C-C triple bond transformations
… which provides 1,4-disubstituted 1,2,3-triazoles has been reported in 2001. New method for highly funtionalized 1,2,3-triazole synthesis becomes very desirable along with the discovery of unique properties of this heterocyclic structure. Our group focused on the synthesis of functional …
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Reactividad de imidazoles y triazoles coordinados a fragmentos metálicos: formación de enlaces C-C o M-C
… desprotonación de N- alquilimidazoles o N- alquiltriazoles coordinados a fragmentos organometálicos catiónicos. Estos complejos metálicos podrían considerarse análogos a las sales de azolio correspondientes (imidazolio o triazolio) y su desprotonación da lugar a especies muy reactivas con un átomo …
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Investigations into the Manipulation of 1,2,3-Triazoles and Towards an Asymmetric ‘Click’ Reaction of Meso Bis-Alkynes
… undertaken to generate various substituted 1,2,3-triazoles and a small group of bis alkyne-containing compounds, followed by their attempted application in an asymmetric ‘click’ reaction. The first chapter gives an outline to the importance of desymmetrization within organic synthesis, providing …
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Reacciones de creación de enlaces C-N y C-C catalizadas por Pd: Síntesis de NH-1, 2, 3-triazoles y olefinas sustituidas
… de sodio con haloalquenos. Síntesis de NH-1,2,3-triazoles" y "Reacciones de formación de enlaces C-C catalizadas por paladio a partir de N-tosilhidrazonas". Este último capítulo se encuentra dividido a su vez en dos partes: "Síntesis de enoléteres y enaminas" y "Síntesis de olefinas enantiopuras: …
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Morphological and physiological growth responses of Kentucky bluegrass to foliar applications of iron, a cytokinin, and growth regulator- like chemicals
… bluegrass. Repeated applications of BA, the triazoles, or MZ63 in late summer or fall and spring tended to slightly increase post-transplant rooting and sod strength of Kentucky bluegrass as compared to single applications. Repeated applications of Fe applied alone in late summer or fall and …
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ΜΕΛΕΤΗ ΦΩΤΟΧΗΜΙΚΩΝ ΑΝΤΙΔΡΑΣΕΩΝ 1-(Ν-1,2,3-ΤΡΙΑΖΟΛΥΛΟ)-ΙΜΙΔΙΩΝ
… WHICH LED TO THE FORMATION OF THE 1(2)H-1,2,3-TRIAZOLES AND DIBENZAMIDE. IRRADIATION OF THE 1- (N,1,2,3-TRIAZOLYL)-IMIDES THROUGH A QUARTZ FILTED LED TO THE SAME PRODUCTS, AS PREVIOUSLY MENTIONED, VIA A Π*-ASSISTED B- CLEAVAGE OF THE N-N BOND. THE TRIAZOLES WERE ALSO IRRADIATED IN THE PRESENCE …
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The Use of Natural Product Substrates for the Synthesis of Libraries of Biologically Active, New Chemical Entities
… It was also shown by making the 1,4-substituted triazoles and the 1,5-substituted triazoles 91, 92 that only the 1,4-substituted triazoles gave the aforementioned activities. These results illustrate the vital importance of stereochemistry and regiochemistry. To establish the importance of the …
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The Use of Natural Product Substrates for the Synthesis of Libraries of Biologically Active, New Chemical Entities
… It was also shown by making the 1,4-substituted triazoles and the 1,5-substituted triazoles 91, 92 that only the 1,4-substituted triazoles gave the aforementioned activities. These results illustrate the vital importance of stereochemistry and regiochemistry. To establish the importance of the …
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Structural manipulation of conjugated polymers
… diynes are coupled to produce a library of 1,2,3-triazoles and new conjugated polymers, poly(arylenetriazoline)s.
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Loss of the SAC Components SldA Kinase or SldB or in vitro Adaptation to Triazole Produces Aneuploidy Associated with Triazole Heteroresistance in Aspergillus fumigatus
… animal invasive filamentous fungal infections. Triazoles, the primary therapeutic options to combat invasive aspergillosis (IA), target the fungal biosynthesis of ergosterol, a vital component of the fungal cell membrane. Unfortunately, resistance to this class of medical therapeutic has arisen …
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Design and Synthesis of CB1 Receptor Ligands and Synthesis of Amphibian Alkaloids
… and a series of 4,5- diaryl-2-substituted-1,2,3-triazoles. Our research group has been interested in the synthesis of amphibian alkaloids due to their interesting biological activities. We have recently developed a general synthetic strategy which can rapidly prepare a few amphibian alkaloids …
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Development of biotin protein ligase inhibitors from Staphylococcus aureus as new antibiotics
… ring to generate 1,4,5- trisubstituted 1,2,3-triazoles. A class of 5-iodo 1,2,3-triazoles was synthesised from 1- iodoacetylene 4.02 and azides using CuAAC. Subsequent halogen exchange reaction allowed conversion of iodide to other halogens. 5-Fluoro-1,2,3-triazole 4.07, the lead compound from …
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Lewis acid catalysis in organic synthesis
… system gives only 1,4-disubstituted 1,2,3-triazoles. Reactions of Alkyl and aryl azides with a variety of terminal alkynes were successfully catalyzed using CuCl-RTIL catalytic system. This catalytic system has the additional characteristics includes simple product isolation, insensitivity …
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Flow-IEG enables programmable thermodynamic properties in sequence-defined unimolecular macromolecules
… increased with higher proportions of 1,4- to 1,5-triazoles, from which a set of predictive design rules was developed and applied to a second library of diblock copolymers. Furthermore, we discovered that the crystallization properties of these macromolecules were highly dependent on both their …
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Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus
… against A. fumigatus are the mold-active triazoles and amphotericin B, of which the triazoles commonly represent both front-line and salvage therapeutic options. Unfortunately, the treatment of infections caused by A. fumigatus has recently been further complicated by the global emergence …
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SÍNTESE DE NOVOS POTENCIAIS ANTAGONISTAS DO NMDA SUBTIPO NR2B DO SISTEMA NERVOSO CENTRAL BASEADOS EM CARBOXAMIDAS TRIAZÓLICAS
… of new amines and amides 1,2,3 - and 1,2,4 - triazoles, which were viewed as intermediates in the syntheses of new amino carboxamides with potentials antagonistic activities of the N-methyl-D-aspartate in the central nervous system. While the 3-amine-5-trifluoromethyl-2H-1,2,4-triazole (2) was …
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