Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 114 for “"triazole"”.
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Loss of the SAC Components SldA Kinase or SldB or in vitro Adaptation to Triazole Produces Aneuploidy Associated with Triazole Heteroresistance in Aspergillus fumigatus
… animal invasive filamentous fungal infections. Triazoles, the primary therapeutic options to combat invasive aspergillosis (IA), target the fungal biosynthesis of ergosterol, a vital component of the fungal cell membrane. Unfortunately, resistance to this class of medical therapeutic has arisen …
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Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus
… against A. fumigatus are the mold-active triazoles and amphotericin B, of which the triazoles commonly represent both front-line and salvage therapeutic options. Unfortunately, the treatment of infections caused by A. fumigatus has recently been further complicated by the global emergence …
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Invitro antibacterial activity of imidazole and triazole-based antimicrobials against Carbapenem Resistant Enterobacteriaceae
Thesis submitted in fulfilment of the requirements for the degree of Masters of Technology: Biomedical Technology, Durban University of Technology, Durban, South Africa, 2017.
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The influence of oils on the toxicity of 3-amino-1,2,4-triazole on quackgrass
Thesis (M.S.)--Michigan State University. Dept of Horticulture, 1967
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Quinoline-triazole half-sandwich iridium(III) complexes: Synthesis, antiplasmodial activity and preliminary transfer hydrogenation studies
… strains. Two series of 7-chloroquinoline-1,2,3-triazole ligands, one with the direct attachment of the triazole to the quinoline and one where the two entities are separated by an aminopropyl linker, were synthesised. Coordination of selected ligands with [IrCl(μ-Cl)(Cp*)]₂ yielded six neutral, …
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The synthesis and in vitro evaluation of short interfering RNA containing triazole functionalized sphingolipid-based derivatives
… we design a library of siRNAs containing propyl-triazole modified sphingosine at various locations of the sense and antisense strand of the reporter gene firefly luciferase and evaluate its gene-silencing abilities in both the presence and absence of a transfection carrier.
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Pyrrolo[2,3-d]pyrimidine-based π-conjugated fluorophores with 1,2,3-triazole and ethynyl linkers: synthesis and photophysical properties /
… based oligoarylenes with ethynyl and 1,2,3-triazole linkers and to evaluate their photophysical properties. Novel chromophores - 2,4-bis(4-aryl-1,2,3-triazol-1-yl)pyrrolo[2,3-d]pyrimidines were prepared by CuAAC reaction. It was demonstrated that in the CuAAC reaction of …
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Design, Synthesis and Biological Evaluation of Novel Estradiol-Triazole Analogs Targeting Epidermal Growth Factor Receptors in Colorectal Cancer
… Additionally, pharmacophores such as 1,2,3-triazole showed potency towards many diseases including cancer. Therefore, incorporation of 1,2,3-triazole on a carrier such as estradiol could lead to novel analogs in drug discovery for treatment of cancer. A library of 800 compound containing …
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An examination of the effects of the catalase inhibitor 3-amino-1,2,4-triazole on ethanol, food and water intake
… effects of the catalase inhibitor 3-amino-1,2,4-triazole (AT) were examined on ethanol, food and water intakes to determine if it produced a decrease in ethanol consumption through the decrease in catalase produced acetaldehyde or to a general decrease in caloric intake. Experiment 1A …
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1,2,3-triazoles as X-factor in gold(I) activation of challenging C-C triple bond transformations
… which provides 1,4-disubstituted 1,2,3-triazoles has been reported in 2001. New method for highly funtionalized 1,2,3-triazole synthesis becomes very desirable along with the discovery of unique properties of this heterocyclic structure. Our group focused on the synthesis of functional …
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SÍNTESE DE NOVOS POTENCIAIS ANTAGONISTAS DO NMDA SUBTIPO NR2B DO SISTEMA NERVOSO CENTRAL BASEADOS EM CARBOXAMIDAS TRIAZÓLICAS
… of new amines and amides 1,2,3 - and 1,2,4 - triazoles, which were viewed as intermediates in the syntheses of new amino carboxamides with potentials antagonistic activities of the N-methyl-D-aspartate in the central nervous system. While the 3-amine-5-trifluoromethyl-2H-1,2,4-triazole (2) was …
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Synthesis and characterisation of mononuclear and dinuclear rhenium carbonyl complexes
… of a series of 3-(pyridin-2-yl)-l,2,4-triazole ligands and the corresponding rhenium(I) tricarbonyl. The structure of the complexes have been determined using NMR and IR spectroscopy. The complexes underwent [Re—>7t*(pyridyl-triazole)] transitions in the 295 - 360 nm region of the …
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Exploration of a template-directed approach for the synthesis of silver nanoparticles
… focuses on the preparation of a series of sugar triazole ligands to template the formation of monodisperse AgNPs in a size- and shape-controlled manner. Chapter 1 introduces the optical properties of metal nanoparticles and the common methods for the preparation of AgNPs, highlighting the …
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JULIA-KOCIENSKI APPROACH TO 4-SUBSTITUTED 1- ALKENYL-1H-1,2,3-TRIAZOLES
… to the synthesis of 4-substituted N-vinyltriazoles was<br />developed. The triazole cores were assembled by copper-catalyzed 1,3-dipolar<br />cycloaddition of 1-phenyl-1H-tetrazol-5-yl (PT) azidomethyl sulfide with: pmethoxyphenyl, 2-pyridyl, and triisopropylsilyl alkynes. Subsequent …
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Design, Synthesis and Biological Evaluation of Novel Cannabinoid Antagonist
… target was to incorporate a bioisosteric 1,2,3-triazole ring into the vicinal diaryl group revealed in the prototypical antagonist/inverse agonist SR141716 (Rimonabant) that was presumed to interact with a unique region in the CB1 receptors. Based on our preliminary results we identified a …
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Synthesis of Bicyclic and Tricyclic Analogues of Oxazolidinone
… tricyclic piperazine analogues and tricyclic triazole analogues of ANB-22 and ANB-40. </p><p>By employing the aziridine-ring-opening and the Mitsunobu reaction, a series of fused bicyclic and tricyclic oxazolidinone-piperazine derivatives have been prepared. Using similar synthetic strategy …
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Development of biotin protein ligase inhibitors from Staphylococcus aureus as new antibiotics
… over the mammalian equivalent using 1,2,3-triazole and acylsulfonamide isosteres to replace the phosphoroanhydride linker found in biotinyl-5’-AMP 1.03. Chapter one describes the structure and catalytic mechanism of the target enzyme SaBPL, along with an overview of chemical analogues of …
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The synthesis and in vitro evaluation of siRNAs modified at the backbone with a novel triazole-based internucleotide linkage and abasic alkyl-chain linkages of varying length
… on synthesizing novel and neutrally-charged triazole-linked nucleoside dimer analogs which were incorporated throughout siRNA duplexes using DMTphosphoramidite chemistry, in order to attenuate the negative contributions of RNA′s native backbone. In order to further elucidate the mechanism of …
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Triazole-linked reduced amide isosteres: An approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors and NH-assisted Fürst-Plattner opening of cyclohexene oxides
… microtiter plate-based screening to discover 4 triazole-linked reduced amide isosteres that showed modest (single digit micromolar) BACE1 inhibition. Our ligands were designed based on a very potent (single digit nanomolar) isopththalamide ligand from Merck. We supplanted one of the amide …
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