Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 4591 for “"trials"”.
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Bayesian Adaptive Designs For Proof-of-Concept Trials and Platform Trials
… drug development paradigm in phase II trials becomes increasingly inefficient due to its slow progress, high cost, and high failure rate. Fitting one standard strategy to all different trials also harms its reliability in decision-making because it doesn’t fully use all available …
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Curtailed phase II binary outcome trials and adaptive multi-outcome trials
Phase II clinical trials are a critical aspect of the drug development process. With drug development costs ever increasing, novel designs that can improve the efficiency of phase II trials are extremely valuable. Phase II clinical trials for cancer treatments often measure a binary outcome. The …
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Stargardt disease - Toward clinical trials
Contains fulltext : 197556.pdf (Publisher’s version ) (Open Access)
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Responder Identification in Clinical Trials
The thesis gives an overview of the techniques used up to now for responder identification and it proposes a new method for systematic search for responders. The responder identification method consists of the following three steps: 1. Identification of prognostic factors (e.g. via Cox-PH model on …
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Ethical Challenges in Cluster Randomized Trials
Research Questions: This dissertation examines how ethical challenges in CRTs are addressed in practice. This dissertation also provides guidance as to who must be considered a research subject in a CRT, and when consent must be sought from research subjects. Methods: The association between …
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Admissibility of confessions in criminal trials
A confession may be defined as an out-of-court statement by a suspect in which he or she voluntarily, knowingly and intelligently acknowledges that he or she committed or participated in the commission of a crime and which makes it clear that there is no defence in law that would make his or her …
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The media's coverage of jury trials
… and extent of the print media's coverage of jury trials. A content analysis was conducted on the Los Angeles Times from 1973 to 1995, examining both overall trends in jury coverage and the extent and nature of that coverage before and after several high-profile jury trials. The findings of the …
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Design and conduct of therapeutic trials
… thesis to examine Army experience of therapeutic trials. The major factual contribution to this thesis is the section dealing with syphilis therapy in. the Army. For the conduct of this the candidate was wholly responsible, with such clerical assistance as given by junior members of the Army …
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Data-driven Analysis of Clinical Trials
… combines two studies in the field of clinical trials. The first evaluates the amyotrophic lateral sclerosis (ALS) drug AMX0035 using Bayesian decision analysis (BDA), balancing FDA safety standards with patient needs. This method provides a quantitative way to consider both the patient’s …
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System identification applied to maneuvering trials.
Massachusetts Institute of Technology. Dept. of Ocean Engineering. Thesis. 1973. Ocean E.
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Investing in Clinical Trials for Older Adults: The Value and Challenges of Older Adult-Specific Clinical Trials
Conducting clinical trials for older adults can address the long-standing issue of the underrepresentation of older adults and the lack of clinical evidence for them. Examining the challenges and the value of such trials could facilitate discussion among trial sponsors on the investment in and the …
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THE EXTERNAL VALIDITY OF RANDOMIZED CLINICAL TRIALS.
THE EXTERNAL VALIDITY OF RANDOMIZED CLINICAL TRIALS.
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Recruitment to randomised controlled trials with children
Recruitment to randomised controlled trials is known to be difficult. Poor recruitment has several adverse consequences. It affects the validity of study findings, is a common cause of trial extensions and may result in premature termination of trials, which is a huge loss in terms of invested …
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John Adams and the Boston Massacre trials
Digitized by Kansas Correctional Industries
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Biases toward defendants in joint criminal trials
… in the legal arena as to the utility of joint trials, although to date little empirical research exists to substantiate any of the claims made. The present study aimed to contribute to the sparse knowledge base on joint trials by examining the impact of evidence strength on juror decision …
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Quality aspects of Dutch colorectal cancer trials
Contains fulltext : 173476.pdf (Publisher’s version ) (Open Access)
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Novel methods for early phase clinical trials
Early phase clinical trials are conducted with limited time and patient resources. Despite design restrictions, patient safety must be prioritised and trial conclusions must be accurate; maximising a promising treatment’s chance of success in later largescale, long-term trials. Increasing the …
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Gender, Spatial Learning Trials, and Object Recall.
… in object recall over three memorization trials using gender neutral stimuli. Fifty men and 53 women viewed pictures of 60 objects (15 in each of four quadrants) for one minute, and then had three minutes to recall as many objects and locations as they could. This procedure was followed …
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