Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 60 for “"trial data"”.
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Aligning synthetic clinical trial data with human-preferred clinical endpoints
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Statistical model selection techniques for the cox proportional hazards model: a comparative study
The advancement in data acquiring technology continues to see survival data sets with many covariates. This has posed a new challenge for researchers in identifying important covariates for inference and prediction for a time-to-event response variable. In this dissertation, common Cox proportional …
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Recent Advances on Statistical Network Analysis and Multi-task Learning for Complex Data
Real-world data are increasingly complex, arising from diverse domains that demand sophisticated analytical approaches. This dissertation focuses on developing advanced statistical methods to address the challenges in analyzing social network data and clinical trial data. First, I propose a novel …
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Modeling correlations in clinical trial outcomes using machine learning
… of characterizing the covariance of clinical trial outcomes using drug and trial features. The binary nature of FDA approvals makes drug development risky, but approaches in finance theory could better manage that risk, allowing more high potential drugs to be developed. To apply these methods …
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L1-Adaptive Control for Anesthesia Delivery
… models constructed using clinical trial data. Two different L1-adaptive control schemes, a state-feedback scheme and an output-feedback scheme, will be evaluated and compared in terms of tracking performance, amount of anesthesia used, and robustness to interpatient variability.
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From Oncogenesis to Immunotherapy: Mathematical Modeling of Heterogeneous Cancers
… lymphoma, Richter’s Syndrome (RS), we analyze data from a recent mouse model and utilize a Bayesian modeling approach to show that growth patterns present in human disease are recapitulated in murine CLL/RS. Next, we use a stochastic branching process model to simulate the acquisition of …
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Accelerated breeding for winter wheat profitability in a wheat-soybean double-crop system
… realized genetic change using long-term yield-trial data and control-population methods. Chapter 3 develops a profit-maximizing genomic selection index that incorporates grain price, test-weight discounts, and soybean yield penalties associated with later heading; the index is evaluated with …
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Effects of Variable Payoff Structures on Cooperative Behaviors in a Repeated Prisoners Dilemma Game
… communicating with their dyad partners in each trial. Data were analyzed both in terms of group data, as well as individual within-subject data presented per participant. The results showed that individual levels of cooperation varied with no major trends distinguishing the effects of the …
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Comparison of Apixaban and left atrial appendage exclusion device (Watchman) in preventing stroke and systemic embolism in atrial fibrillation patients
<p>Atrial fibrillation is a cardiac arrhythmia associated with increased risk of stroke and systemic embolism. Apixaban, an oral anticoagulant, and the Watchman, a left atrial appendage closure device, are the currently used therapeutic treatments for the prevention of stroke and systemic embolism …
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From bench to bedside : impact of conflict-of-interest restrictions at academic medical centers on clinical trials
… is better characterized with clinical trial data. The findings suggest that there is a strong trend towards schools with higher conflict-of-interest rules having fewer clinical trials. This suggests that although there may be benefits to stricter regulation, there are trade-offs in …
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Assessing the Benefits of Virginia Tech Agricultural Programs: Studies in Feeder Cattle Certification and Small Grains Breeding
… conducted by Virginia Tech researchers. Variety trial data are combined with acreage estimates constructed from royalty data to estimate gains from replacement of old varieties with new ones. The study finds that the program generated benefits to producers of over $119 million between 2000 and …
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Machine-learning models for predicting drug approvals and clinical-phase transitions
… transitions using drug-development and clinical-trial data from 2003 to 2015 involving several thousand drug-indication pairs with over 140 features across 15 disease groups. Imputation methods are used to deal with missing data, allowing us to fully exploit the entire dataset, the largest of its …
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Estimation of clinical trial success rates and related parameters
… small samples of pharmaceutical industry-curated databases, which are subject to potential sample selection biases. Using a sample of 185,994 unique entries of clinical-trial data for over 21,143 compounds from January 1st, 2000 to October 31st, 2015, we estimate aggregate success rates and …
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Policy analysis of foreign trials needed for FDA-approved INDs for devices and drugs from 2016 to 2020
… it to the market, the need for multinational data is more necessary for drugs in comparison to medical devices. Since drugs do not always need additional data, there is a need to investigate why medical devices are more easily approved than drugs. The use of foreign data is fairly recent, and …
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Advancing Sustainable Grape Downy Mildew Management: Biopesticide Trials and Risk Assessment System
… conventional fungicides in field and greenhouse trials from 2024 to 2025 across multiple Vitis vinifera cultivars in Virginia. Among biopesticides, the GEA 249 complex, Bacillus mycoides Isolate J, and Pseudomonas chlororaphis strain AFS009 showed results comparable to conventional fungicides …
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The Characterization of T-Cell Manufacturing For Adoptive T-Cell Therapies
… performed a meta-analysis of available clinical trial data to show that younger patients appear to respond better to T-cell manufacturing involving CD28 costimulation, while older patients appear to respond better to T-cell manufacturing lacking CD28 costimulation.</p>
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Drug deposition and distribution in healthy and atherosclerotic arteries and in models of atherosclerosis following bulk or stent-based drug delivery
… more than four years after introduction clinical trial data and clinical use have still not fully clarified what drives the safety and efficacy of these devices. The goal of this thesis was to help fill this void by describing the mechanisms by which stent-eluted drugs are distributed within …
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Mathematical Models of Immune Responses to Infectious Diseases
… antibody therapy. We fit the models to clinical trial data and conclude that antibody binding is delayed and that the combined effects of initial CD4 T cell count, initial HIV levels, and virus production are strong indicators of a good response to antibody immunotherapy.
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The Effects of Pyramidal Training on Staff Acquisition of Five Behavior Analytic Procedures
… preference assessment, mand training, discrete trial teaching, and graphing discrete trial data). Pyramidal training was effective in increasing first tier participants’ procedural integrity of behavioral skills training steps and in increasing second tier participants’ procedural integrity of …
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Parent Management Training in Primary Care: Feasibility, Acceptability, and Preliminary Results
… primary care setting. Additionally, preliminary data were provided regarding a small N randomized control trial conducted in a primary care setting. The trial utilized either a one-session intervention comprised of evidence-based Parent Management Training components or a supportive therapy …
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