Global ETD Search
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Showing 1 to 2 of 2 for “"trehalose dimycolate"”.
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Cell Wall Lipids Promoting Host Angiogenesis During Mycobacterial Infection
… host angiogenesis. We found that PcaA-modified trehalose dimycolate, an abundant glycolipid in the mycobacterial cell wall, drives activation of host VEGF signaling and subsequent granuloma vascularization. To facilitate our continuing investigation of granuloma dynamics, we next sought to …
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Immune Modulation of The Mycobacterium Tuberculosis Granulomatous Response
… innate mechanisms of mycobacterial cord factor trehalose-6’6-dimycolate (TDM) on granuloma formation. Investigations using knock-out mice suggest that TNF-a is involved in the initiation of the granulomatous response, complement factor C5a generates granuloma cohesiveness, and IL-6 is necessary …