Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"treatment-resistant depression"”.
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Management of treatment resistant depression /
Treatment-Resistant Depression poses a substantial challenge in psychiatric care, where individuals often do not respond adequately to standard antidepressant therapies. This dissertation provides a narrative review of current literature on Treatment-Resistant Depression, with a focus on exploring …
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Ready, Set, Action: Potential Breakthrough Therapy for Treatment-Resistant Depression
… Current psychological and pharmacological treatments have been demonstrated efficacious; however, an ever-growing number of individuals frequently report minimal to no improvement with these treatments; and in some cases, a worsening of symptoms. This inadequacy to treatment is commonly …
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Investigating markers of accelerated aging in patients with Treatment Resistant Depression
… utility of aging markers in the management of treatment response. Pharmacological treatments represent the main approach in mood disorders, but treatment resistance concerns 10–30% of patients with major depressive disorder (MDD) and 75% of cases of unresolved morbidity of bipolar disorder (BD) …
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Suicidal Ideation and Treatment-Resistant Depression: Clinical Endophenotype Characterization and Exploration of Novel Brain Stimulation Interventions
… (SI) is more prevalent in individuals with treatment-resistant depression (TRD) compared to those with depression who respond to treatment. Given treatment limitations of SI in TRD, novel interventions paired with an improved understanding of the neurobiology of SI are needed. In this thesis …
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Epigenetic and expression-based modifications of depression-relevant genes as peripheral biomarkers for treatment-resistant depression and major depressive disorder
Mechanisms contributing to treatment resistant depression (TRD) and major depressive disorder (MDD) are poorly understood. Identifying peripheral biomarkers in an easily accessible tissue, such as whole blood, will enhance the mechanistic understanding of these disorders and could potentially …
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A Study of the Relationship between Borderline-dysregulated Personality and Treatment-resistant Depression in the Course of the TADS Randomised Controlled Trial
… personality disorder, difficult to treat depression and treatment outcome. Method: The study used data collected in the course of the Tavistock Adult Depression Study (TADS). The TADS was a randomised controlled trial comparing Long Term Psychodynamic Psychotherapy (LTPP) to Treatment as …
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HPA Axis Dysfunction In Treatment Resistant Affective Disorders
Background: TRD (Treatment Resistant Depression) patients have been shown to have hypercortisolemia and a hyperactive HP A (hypothalamo-pituitary-adrenal) axis. The Cortisol Awakening Response (CAR) is a naturalistic measure of the HP A axis activity. Although found to be elevated in depression, it …
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Optimizing Treatment for Depression: Integrating TMS and Ketamine Through Provider and Clinical Staff Education
… Stimulation (TMS) and ketamine for treating treatment-resistant depression (TRD). TRD affects a significant number of individuals who have Major Depressive Disorder (MDD) and often do not respond to traditional antidepressant therapies, thus leading to a need for other modalities. Novice …
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Análise da eficácia e segurança do uso da cetamina endovenosa na depressão unipolar resistente ao tratamento: revisão sistemática de ensaios clínicos randomizados
… OF THE USE OF INTRAVENOUS KETAMINE IN UNIPOLAR TREATMENT-RESISTANT DEPRESSION: SYSTEMATIC REVIEW OF RANDOMIZED CLINICAL TRIALS. Objective: To evaluate the results associated with the efficacy and safety of the therapeutic use of ketamine in the treatment-resistant depression (TRD) Introduction: …
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Clinical, Metabolic and Inflammatory Indicators of Esketamine Efficacy for Treatment-Resistant Major Depressive Episodes
… poses a significant challenge. Individuals with treatment-resistant depression (TRD) often experience severe symptoms and elevated suicide risk. Metabolic and inflammatory abnormalities may contribute to inadequate response to treatments. Esketamine has demonstrated promise in TRD, but its …
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Predictors of Response to Repetitive Transcranial Magnetic Stimulation Treatment in Adolescent Major Depressive Disorder
Adolescent major depressive disorder has limited treatment options and response is unpredictable. Repetitive transcranial magnetic stimulation (rTMS) is a novel treatment option while pre-treatment cortical thickness may be an objective biomarker predictive of response. Twenty-three youth (12-21 …
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Establishing Neurocognitive Profiles of Major Depressive Disorder Subtypes
… In particular, the neurocognitive impact of the treatment resistant depression (TRD), defined as MDD that is unresponsive to treatment, and psychotic depression, defined as a depressive episode with hallucinations and/or delusions, is unknown despite the significant illness burden these subtypes …
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Peripheral Inflammation and Activity within Corticostriatal Reward Circuitry: Interactive Roles in Components of Anhedonia during Adolescence
Depression is a significant global health burden, affecting millions of people worldwide and contributing to a high level of disability. Despite the availability of treatments, a substantial proportion of individuals experience insufficient treatment response. Anhedonia often is observed in …
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Cognitive Performance as A Function of Right-Sided, Low-Frequency rTMS Administration Using CNS Vital Signs
… the research as the most efficacious options for treatment resistant depression. However, due to the neurocognitive deficits associated with ECT, interest in transcranial magnetic stimulation (TMS), a non-invasive approach that stimulates the cerebral cortex, as an alternative to ECT has become a …
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KETAMINE EXPOSURE DURING ADOLESCENCE INCREASES SENSITIVITY TO REWARD-RELATED STIMULI IN ADULTHOOD
… below 20 years of age, many of whom remain treatment-resistant. Recently, the non-competitive N-Methyl-D-aspartate (NMDA) receptor antagonist, ketamine, has been shown to alleviate symptoms of MDD in individuals that suffer from treatment-resistant depression. However, little is known about …
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A study of the WKY as a rat model of depression
Major depression is a heterogeneous neuropsychiatric disorder with a significant genetic - stress interaction. The Wistar - Kyoto (WKY) rat displays hypersensitivity to stress and depression - like behaviour and is used as a genetic model of major depression. However, the depression - and anxiety - …
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Optimizing the neuromodulation of pathological neural circuits: multiparametric approaches and biomarker prediction
… 4: A DUAL-SITE ACCELERATED rTMS PROTOCOL FOR TREATMENT RESISTANT DEPRESSION, and CHAPTER 5: NEUROIMAGING MECHANISM OF RESPONSE TO DUAL-SITE rTMS, I focused on searching for more effective treatment protocols of TMS for the management of MDD. Considering the cost and time it usually takes for …