Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 36 for “"treatment targets"”.
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Empirical validation of treatment targets for the management of diabetes in children
In the present study we used an empirical validation approach to determine psychosocial variables related to adaptive management of diabetes in two samples of diabetic children and their families. Children from the Kansas University Medical Center (n = 31) and children from the Virginia Diabetes …
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Improving quality of care in inflammatory bowel disease: treatment targets and body composition
… of disease and normalise quality of life (QoL). Treatment directed at objective inflammation has been shown to improve outcomes in IBD, yet represents a paradigm shift for clinicians trained to manage symptoms alone. Beyond conventional treatment targets, abnormal body composition is often …
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Profiling mucinous ovarian cancer and comparisons with tumours of the gastro-intestinal tract: identification of markers for diagnosis, prognosis, and treatment targets.
… (GI) site; and 3) finding better treatment options for patients with advanced stage (III/IV) MOC. Using the international Ovarian Tumor Tissue Analysis consortium, this thesis sought to address these issues. Samples and data were pooled through the consortium for 3 projects: an …
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DYSPHAGIA TREATMENT PLANNING: ASSESSING CLINICIANS’ TREATMENT RECOMMENDATIONS BASED ON MODIFIED BARIUM SWALLOW STUDY REPORTS
… used radiographic procedure for diagnosis and treatment of swallowing disorders. Despite attempts by dysphagia specialists to standardize the MBS, most settings have not adopted such standardized procedures. High variability of assessment patterns arguably contribute to variability of treatment …
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DYSPHAGIA TREATMENT PLANNING: ASSESSING CLINICIANS’ TREATMENT RECOMMENDATIONS BASED ON MODIFIED BARIUM SWALLOW STUDY REPORTS
… used radiographic procedure for diagnosis and treatment of swallowing disorders. Despite attempts by dysphagia specialists to standardize the MBS, most settings have not adopted such standardized procedures. High variability of assessment patterns arguably contribute to variability of treatment …
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OPTIMISATION AND THERAPEUTIC-TARGET-DISCOVERY ORIENTED ANALYSIS OF CRISPR-CAS9 SCREENS
… insights into cancer biology and potential treatment targets. My PhD research focuses on developing tailored tools and pipelines to enhance the analysis of CRISPR-Cas9 screens for identifying cancer therapeutic targets. CRISPR-Cas9 screens are vital in cancer research, allowing precise gene …
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An examination of the implementation of the World Health Organisation's anti-tuberculosis treatment, the Directly Observed Treatment Short Course (DOTS), in poor South African communities
… the implementation of the anti-tuberculosis treatment, the Directly Observed Treatment Short Course, of the World Health Organisation (WHO) in poor South African communities. Research for this dissertation was carried out over a two-year period in one poor community, a tuberculosis (TB) …
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WHAT’S WEIGHING YOU DOWN? OBESITY AND WEIGHT BIAS INTERNALIZATION: AN EXPLORATORY INVESTIGATION ON THE CORRELATES OF WEIGHT BIAS INTERNALIZATION
… with obesity, whilst underscoring potential treatment targets.
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Autism Spectrum Disorder Traits and Parental Stress: The moderating role of parental self-efficacy
… the context of HRV as well as implications for treatment targets and studying parental stress are explored.
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Understanding minor attracted persons
… face many barriers to accessing mental health treatment. This dissertation provides an exploratory analysis of the lived experiences of MAPs from 3 different perspectives. Study 1 is a qualitative analysis of online support forums for MAPs, examining offense avoidance strategies they use when …
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The Nature of Night Eating Syndrome: Using Network Analysis to Understand Causal Symptomological Relationships
… of NES and should represent primary treatment targets for intervention.
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Parental Socialization Of Emotion and Anxiety Among Latinx Youth: The Role of Emotion Dysregulation and Familismo
… should especially be considered as potential treatment targets in psychosocial work with Latinx youth, given the impact of these parental behaviors on children’s emotion regulation and anxiety symptoms. Future studies should continue to elucidate specific parenting and cultural factors …
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An evaluation of monitoring of respiratory physiological parameters in patients treated with non-invasive ventilation in the emergency department in Sligo University Hospital in Ireland
… doubled. Non-invasive ventilation has become the treatment modality of choice in selected patients, with a significant reduction of mortality in these cases. However, adequate monitoring of clinical and blood gas parameters is crucial to ensure treatment targets are met. Objective: This study aims …
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A Comparison Of Nonwords And Tier Two Vocabulary Words In Speech Treatment
… sound disorders (SSD) make slow progress in the treatment of their SSD due to their prior experiences with the words used in treatment. One way to avoid possible biases associated with life experience and semantics (Leonard, Newhoff, & Mesalam, 1980) in the treatment of SSD is to use NWs (e.g. …
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Peripheral Inflammation and Activity within Corticostriatal Reward Circuitry: Interactive Roles in Components of Anhedonia during Adolescence
… level of disability. Despite the availability of treatments, a substantial proportion of individuals experience insufficient treatment response. Anhedonia often is observed in treatment-resistant depression and severe presentations of depression, suggesting that mechanisms underlying anhedonia may …
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A B-cell or a key player?: The role of the humoral immune response in melanoma, highlighting the importance of method development
… with metastasised melanoma prior to receiving treatment were then compared to healthy controls to determine baseline autoantibody characteristics. The effect of treatment on autoantibody profiles and association with clinical response were then investigated. Pre-treatment and post-treatment …
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Pharmacological Intervention Reduces Hippocampal Hyperactivity in a Mouse Model of Psychosis
… psychiatric disorders. Current pharmacological treatment options abound in side effects, leading to poor patient adherence. Therefore, we are in need of novel mechanistic treatment targets. Prior research has identified the molecular and behavioral characteristics of a model in animals …
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Auto-Delineation of Oropharyngeal Clinical Target Volumes Using Deep Learning Techniques
… by conforming radiation dose to the defined treatment targets achieving more accurate target dose distribution and better sparing of normal tissues. However, producing very precise treatment plans may be ineffective if the target volumes are not defined accurately. Furthermore, there are …
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Identification of gene expression changes in human cancer using bioinformatic approaches
… help identify new cancer mechanisms, potential treatment targets, and have significant diagnostic and prognostic implications.
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Tissue adaptations to colitis influence neoplastic risk through clonal interaction
… remodelling and highlighting their potential as treatment targets in the context of Inflammatory Bowel Disease. Colitis in the *Muc2<sup>KO</sup>* model triggered epithelial adaptation in the form of neutral clonal expansion necessary for tissue regeneration. Introduction of cancer-driver …
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