Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"treatment resistant"”.
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Management of Treatment-Resistant Schizophrenia
… antipsychotics respectively. In the case of treatment resistance to the initial antipsychotic trial, there a several approaches to treat patients with treatment-resistant schizophrenia. Some of these include altering the dose, switching between classes or different generic forms, the use of …
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Management of treatment resistant depression /
Treatment-Resistant Depression poses a substantial challenge in psychiatric care, where individuals often do not respond adequately to standard antidepressant therapies. This dissertation provides a narrative review of current literature on Treatment-Resistant Depression, with a focus on exploring …
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HPA Axis Dysfunction In Treatment Resistant Affective Disorders
Background: TRD (Treatment Resistant Depression) patients have been shown to have hypercortisolemia and a hyperactive HP A (hypothalamo-pituitary-adrenal) axis. The Cortisol Awakening Response (CAR) is a naturalistic measure of the HP A axis activity. Although found to be elevated in depression, it …
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Investigation of potential biomarkers of treatment-resistant schizophrenia
… with schizophrenia are diagnosed as having treatmentresistant schizophrenia (TRS) because they still suffer from persistent moderate-to-severe positive symptoms despite treatment with first line medications. Typically they also have poor-outcomes due to the length of time taken to reach this …
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Ketamine Infusions for Treatment-Resistant Major Depressive Disorder
… southeast Wyoming about intravenous ketamine for treatment-resistant major depressive disorder.Background: Intravenous ketamine has been used for several years for analgesia and anesthesia. The use of intravenous ketamine for psychiatric disorders is a new utilization of this anesthetic …
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Ready, Set, Action: Potential Breakthrough Therapy for Treatment-Resistant Depression
… Current psychological and pharmacological treatments have been demonstrated efficacious; however, an ever-growing number of individuals frequently report minimal to no improvement with these treatments; and in some cases, a worsening of symptoms. This inadequacy to treatment is commonly …
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Clozapine in Treatment-Resistant Schizophrenia (TRS): improving access and utilisation
… humans. When the illness does not respond to treatment, it is even more devastating. When a patient fails to respond to two adequate, consecutive antipsychotic treatments, the illness is termed treatment-refractory schizophrenia (TRS). Clozapine is the only licensed and recognised effective …
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Investigating markers of accelerated aging in patients with Treatment Resistant Depression
… utility of aging markers in the management of treatment response. Pharmacological treatments represent the main approach in mood disorders, but treatment resistance concerns 10–30% of patients with major depressive disorder (MDD) and 75% of cases of unresolved morbidity of bipolar disorder (BD) …
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Generation of mismatch negativity in a sample of treatment-resistant schizophrenia patients
… negativity (MMN) was recorded in thirteen treatment-resistant schizophrenic patients and age- and gender-matched fourteen healthy controls. The MMN was obtained by subtracting the standard from the deviant event-related potential (ERP) brain wave. Subjects responded to infrequent visual …
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Ube4B Levels Determine The Efficacy of Egfr and Stat5 Inhibitors In Treatment Resistant Neuroblastoma
… We examined whether depletion of UBE4B in a chemoresistant neuroblastoma cell line would affect tumor responses to drugs that specifically target selected proteins that are upregulated in the absence of UBE4B. UBE4B depletion in a resistant neuroblastoma cell line resulted in a number of proteins …
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Clinical, Metabolic and Inflammatory Indicators of Esketamine Efficacy for Treatment-Resistant Major Depressive Episodes
… poses a significant challenge. Individuals with treatment-resistant depression (TRD) often experience severe symptoms and elevated suicide risk. Metabolic and inflammatory abnormalities may contribute to inadequate response to treatments. Esketamine has demonstrated promise in TRD, but its …
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Identification Of A Treatment-Resistant, Ketamine-Sensitive Genetic Line In The Chick Anxiety-Depression Model
… Introducing effective pharmacotherapies for this treatment-resistant population is hindered by the lack of pre-clinical screening assays that accurately model the clinical features of TRD. The purpose of this research was to screen representatives of different classes FDA-approved antidepressants …
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Suicidal Ideation and Treatment-Resistant Depression: Clinical Endophenotype Characterization and Exploration of Novel Brain Stimulation Interventions
… (SI) is more prevalent in individuals with treatment-resistant depression (TRD) compared to those with depression who respond to treatment. Given treatment limitations of SI in TRD, novel interventions paired with an improved understanding of the neurobiology of SI are needed. In this thesis …
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Treatment-resistant ophthalmoplegia in myasthenia gravis: Clinical, molecular and functional studies of patient-derived orbital tissues
… receptor positive MG (AChR-MG), may manifest treatmentresistant extraocular muscle weakness despite the use of standard immune therapies. The pathogenetic mechanisms involved in the development of treatment-resistant ophthalmoplegia in MG are still unknown and no effective treatment currently …
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Acceptance and commitment therapy (ACT) process and outcome: a systematic evaluation of ACT for treatment resistant patients
… successes, approximately 30-50% of patients are resistant to this form of treatment. This trans-diagnostic group of treatment resistant patients typically have chronic, co-morbid, and/or personality disordered symptoms and often engage in a range of maladaptive behaviours (e.g., substance abuse, …
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Investigating Clozapine-Induced Myocarditis in Stem Cell-Derived Cardiomyocytes from Treatment-Resistant Schizophrenia Patients: A Pharmacoepigenomic Approach
… an antipsychotic with proven efficacy for treatment-resistant schizophrenia, is often underutilized due to the risk of severe side effects such as myocarditis (cardiac inflammation). This study explores whether epigenetic regulation may predispose individuals to clozapine-induced …
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Epigenetic and expression-based modifications of depression-relevant genes as peripheral biomarkers for treatment-resistant depression and major depressive disorder
Mechanisms contributing to treatment resistant depression (TRD) and major depressive disorder (MDD) are poorly understood. Identifying peripheral biomarkers in an easily accessible tissue, such as whole blood, will enhance the mechanistic understanding of these disorders and could potentially …
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Molecular analysis of decay accelerating factor as a potential susceptibility factor to developing treatment resistant extraocular muscle involvement in Myasthenia Gravis
… ancestry develop immunosuppressive therapyresistant extraocular muscle (EOM) dysfunction. We hypothesized that these patients have deficient DAF expression in their EOMs resulting in less protection from complement injury.
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A Study of the Relationship between Borderline-dysregulated Personality and Treatment-resistant Depression in the Course of the TADS Randomised Controlled Trial
… disorder, difficult to treat depression and treatment outcome. Method: The study used data collected in the course of the Tavistock Adult Depression Study (TADS). The TADS was a randomised controlled trial comparing Long Term Psychodynamic Psychotherapy (LTPP) to Treatment as Usual (TAU) for …
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PTSD Symptom Severity and Neurocognitive Performance as a Function of Combined TMS and Imaginal Exposure in OIF/OEF Combat Veterans with Treatment Resistant PTSD
… with a standardized exposure protocol for the treatment of chronic, treatment-resistant PTSD. The aims are to (1) determine if the treatment is safe and well tolerated, (2) determine if PTSD and concomitant depression and anxiety symptoms improve, and (3) determine if executive functioning and …
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