Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 64 for “"treatment resistance"”.
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Decoding Treatment Resistance and Genotype-Phenotype Interactions at Single Cell Resolution
… (TME) mediate chemoradiation (CRT) resistance in esophageal adenocarcinoma (EAC) is key for improving the low treatment response rate in the clinic. Here, we generated single cell transcriptomics data of 302,035 cells from N=83 longitudinal samples that was used to identify TME and …
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The Impact of Insight, Psychological Functioning, and Treatment Resistance on Completion of Diversion Programs
… difficulty providing inmates with mental health treatment in general. Within correctional facilities, various treatment programs are available for inmates; however, there is limited access due to limited resources, limited staff, or lack of awareness of these programs. Similarly, there are mental …
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Detection and monitoring of treatment resistance in metastatic cancer through non-invasive DNA methylation-based biomarkers
… (MRD) assessment to dynamic monitoring of treatment response and molecular profiling in advanced disease. Low ctDNA plasma concentrations, relevant to many clinical scenarios, as early-stage disease and disease monitoring during initial lines of metastatic treatment, represent a major …
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Interpreting transcriptional signatures and their relevance to disease biology, prognosis and treatment resistance in colorectal cancer
… disease heterogeneity are likely to influence treatment strategies further in the future. Therefore, patient stratification is paramount in order to improve patient response to treatment, improve survival outcome and reduce the risk of relapse. Computational algorithms using a bioinformatics …
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Identifying the molecular basis for treatment resistance in a subset of myasthenia gravis patients of African ancestory
… holds promise as a potentially effective treatment for MG patients with the C>G SNP. Moreover, using a calcein assay, clinically relevant doses of prednisone in combination with MG patient sera was shown to significantly increase the susceptibility of C>G DAF lymphoblasts to cell lysis …
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Management of Treatment-Resistant Schizophrenia
… antipsychotics respectively. In the case of treatment resistance to the initial antipsychotic trial, there a several approaches to treat patients with treatment-resistant schizophrenia. Some of these include altering the dose, switching between classes or different generic forms, the use of …
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Statistical Methods For Resolving Intratumor Heterogeneity With Single-Cell Dna Sequencing
… genotypes, which drives progression and treatment resistance. Such genetic intratumor heterogeneity plays a role in the process of clonal evolution that underlies tumor progression and treatment resistance. Single-cell DNA sequencing is a promising experimental method for studying …
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Investigating intratumoural heterogeneity and plasticity with multiplexed single-cell assays
… are limited and variable across cancer types. Treatment resistance remains a universal feature contributing to poor cancer patient outcomes in the clinic and KRAS inhibitors have limited efficacy in patients with KRAS-mutant colorectal cancer (CRC). Genetic mutations alone do not fully explain …
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Advanced Microfluidic Platforms for Studying the Stromal Compartment of Pancreatic Cancer Tumor Microenvironments
… a deadly disease of the exocrine pancreas, with treatment resistance attributed to the aggressive biology of the tumor microenvironment (TME). Interactions between activated pancreatic stellate cells (PSCs) and pancreatic cancer cells (PCCs) give rise to dense fibrotic masses (stroma) and the …
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High-Resolution Array Comparative Genomic Hybridization Identifies Common Targets in Rhabdomyosarcoma
… extremities, has a higher risk of metastasis or treatment-resistance, and in 75% of cases, is characterized by the presence of the PAX3/7:FOXO1A translocation. ERMS is associated with a younger age at presentation, sites of disease other than the extremities, a more favorable clinical outcome, …
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Exploring miR-142-3p in cervical cancer: Implications for treatment response
… cancer remains a major global health burden, and treatment resistance, particularly to cisplatin, significantly limits therapeutic success. MicroRNAs (miRNAs) and extracellular vesicles (EVs) have emerged as important regulators of tumor behavior, with the potential to influence both treatment …
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Directed Evolution of Macrocyclic Peptides For Inhibition of Autophagy
… plays an important role in the development of treatment resistance and dormancy in many cancer types. Chloroquine (CQ) and hydroxychloroquine (HCQ), two autophagy inhibitors in clinical trials, suffer from poor pharmacokinetics and high toxicity at therapeutic dosages. This has prompted intense …
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The role of tunneling nanotubes in mediating intercellular communication in cancer
… of tumor heterogeneity, tumor metastasis, resistance to chemotherapeutic drugs, and the ability of TNT-mediated communication in conditions such as hypoxia that are typical of the tumor microenvironment. If intercellular communication via TNTs proves to be critical to tumor invasion and the …
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Understanding tumor cell plasticity in spatial transcriptomics with graph attention networks and walk-based pseudotime analysis
… progression, heterogeneity, metastasis, and treatment resistance. Tumor cells change states from the conventionally easier to treat epithelial state to the more resistant mesenchymal state. Understanding the transition dynamics of these states and the extrinsic factors influencing them is …
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High Throughput Screening for Small Molecule Interactions with Nucleic Acid Binding Proteins
… from oncogenesis to metastasis, as well as treatment resistance and tumor recurrence. Our ability to manipulate these entities in cells, and therefore our ability to understand their function precisely or to intervene in pathological processes, is extremely limited without genetic …
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The HIV-1 entry inhibition capabilities of Isoflavones
The availability of treatment for HIV infection has resulted in a drastic increase in the life expectancy of infected individuals. However, the current therapeutics fall short in many areas. A considerable 60% of treated individuals will show minor cognitive disorders due to infection, immune …
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Roles of Oxidative Stress and Dna Methylation In Cigarette Smoking-Induced Accelerated Acute Myeloid Leukemia Progression
… continued SE. Cigarette smoke condensate (CSC) treatment of AML cells in vitro was used to study how chemicals from cigarette smoke in the absence of high heat combustion directly impact AML cells. Our SE model and CSC treated AML cells resulted in accelerated leukemic progression in mice. SE …
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Developing a co-culture model of ovarian cancer to identify immunotherapies that can overcome TGF-β-induced immunosuppression
… of patients experience recurrence and subsequent treatment resistance. Immunotherapies have shown limited efficacy against HGSC, which is partly attributed to the presence of immunosuppressive cytokines in the tumor microenvironment (TME), notably transforming growth factor beta (TGF-β). TGF-β …
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Multi-Niche Human Bone Marrow On-A-Chip for Studying the Interactions of Adoptive Cell Therapies with Multiple Myeloma
… and interact with stromal cells and how treatment resistance and relapses arise; yet it is unclear which BM niches (endosteal, central marrow, and perivascular) interact with MM and how various cells of the BM give rise to MM phenotypes and pathophysiology. Therefore, it is important to …
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