Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"treatment of schizophrenia"”.
-
Approaches to Treatment of Schizophrenia as a Function of Evolving Stigma
… twentieth century, Eugen Bleuler coined the term Schizophrenia for a mental disturbance which he noted as being characterized by a separation of emotion and thought (Pridmore, 2016). Bleuler believed the defining feature of Schizophrenia to be a disorganized change in thought (Pridmore, 2016). …
-
Variability in Pricing of Generic Antipsychotic Medications Used in the Treatment of Schizophrenia at Community Pharmacies in the Kansas City Metropolitan Area
… No studies have examined variability in costs of antipsychotic medications or if these costs vary across types of pharmacies. Specifically, comparative drug pricing for generic formulations of five commonly used second-generation antipsychotic medications (risperidone, olanzapine, quetiapine, …
-
New era in the tratment of schizophrenia
Known for centuries, schizophrenia is one of the most famous mental disorders in the world. Schizophrenia has a wide variety of symptoms, which can further be divided into positive and negative symptoms.With the advancement in various disciplines in the last century (such as: biochemistry, cell …
-
Linking dopaminergic physiology to working memory related neural circuitry
… a delay in order to perform a task. This kind of memory is thought to be encoded in the brain by persistent neural activity that outlasts the presentation of a stimulus. Interestingly, patients with schizophrenia, a heritable neurological disorder, perform poorly in working memory tasks that …
-
Molecular Signaling and Agonist Discovery for GPR52
… promising therapeutic target for the modulation of striatal neurons, wherein agonism may be beneficial for the treatment of schizophrenia and psychiatric disorders. The work herein describes the investigation of GPR52 signaling mechanisms, molecular determinants for GPR52 activation, and …
-
The gut microbiota as a contributing factor to antipsychotic-induced weight gain and metabolic dysfunction
Schizophrenia represents one of the world’s most devastating illnesses due to its often lifelong course and debilitating nature. The treatment of schizophrenia has vastly improved over recent decades with the discovery of several antipsychotic compounds; however these drugs are not without adverse …
-
Studies into Amphetamine-Induced Unconditioned Behaviour in the Rat.
Previous work on the unconditioned effects of amphetamine in rats has examined qualitative changes in behaviours which become stereotyped and quantitative changes in locomotion. Stereotyped behaviours have been adopted as a model of raised caudate-putameri function whilst locomotion has been …
-
Studies on the metabolic bioactivation of haloperidol (HP) and its tetrahydropyridine dehydration product
Haloperidol (HP), a member of the butyrophenone class of neuroleptics and a first choice for the treatment of schizophrenia, causes severe extrapyramidal side effects including acute dystonic reactions, akathisia, drug-induced parkinsonism and, following chronic treatment, tardive dyskinesias (TD). …
-
Development of implantable devices for schizophrenia treatment
Schizophrenia is a psychotic condition produced by abnormal levels of neurotransmitters in the brain. One of the drugs that is commonly prescribed to treat schizophrenia is risperidone (RIS). This drug is administered through the oral route (e.g. tablets). Accordingly, the drug is exposed to …
-
Estudo comparativo entre antipsicóticos atípicos no tratamento da esquizofrenia e sua influência na qualidade de vida dos pacientes
Schizophrenia is a severe and persistent mental illness; diagnosis occurs mainly during adolescence. The pharmacological treatment is done with typical and atypical antipsychotics. Atypical have the advantage of reduced extrapyramidal effects, which make them promising for the treatment of …
-
Synthesis and Evaluation of Tetrahydroprotoberberines as Dopamine Receptor Ligands
… <p>Tetrahydroprotoberberines (THPBs) are a group of naturally occurring tetracyclic alkaloids that belong to the tetrahydroisoquinoline family. A wide range of biological activities are associated with the THPB scaffold. Noted examples of THPB alkaloids, (-)-stepholidine <strong>2.1 …
-
Antipsychotic drugs for the treatment of acute schizophrenia after the first episode
… Antipsychotic drugs (APDs) represent the treatment of choice for psychotic disorders, but uncertainty surrounds the optimal selection of agents. Methodology: This was a mixed method study which included a systematic review and psychiatrists’ opinion survey. The systematic review focused on …