Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 115 for “"treatment failure"”.
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Outcomes of patients undergoing lung resection for drug-resistant TB and the prognostic significance of pre-operative positron emission tomography/computed tomography (PET/CT) in predicting treatment failure
… reserve, surgery is an important adjunctive treatment. However, there are no outcome data from TB endemic countries, and the prognostic significance of pre-operative PET-CT findings remains unknown. Objectives: To report outcomes for resectional surgery in our setting, and to study whether …
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Arsenic, antimony and visceral leishmaniasis
… the cure rate of antimonial compounds in the treatment of visceral leishmaniasis (VL) has declined from over 85% to less than 50%. This has been attributed to prolonged, widespread misuse of antimonials within the Indian private healthcare system. An alternative resistance hypothesis is that …
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Outcomes of patients failing first-line antiretroviral treatment in a decentralised programme led by nurses in the Democratic Republic of Congo
Background: Task-shifting of care and first-line treatment for people living with HIV (PLHIV) from doctors to nurses is feasible, effective and acceptable in sub-Saharan Africa. Since first-line resistance to antiretroviral therapy (ART) is increasing, comprehensive HIV care should be informed by …
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VERU-111 as an Oral Tubulin Inhibitor Suppressing Triple-Negative Breast Cancer and Evaluation of Novel Tubulin Inhibitors for Cancer Therapy
… paclitaxel, are effective in treating TNBC. Yet, treatment failure is commonly observed due to the development of acquired chemoresistance, which remains a clinical challenge for TNBC therapy.</p>
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Elucidating the chlamydial growth characteristics, infection factors, and host responses to persistent chlamydial infection in women
… to unresolved and untreated infections. While treatment with azithromycin is highly effective, treatment failure does occur. The mechanisms of treatment failure and its effects on fertility are poorly understood. Unlike other bacterial pathogens, 𝘊. 𝘵𝘳𝘢𝘤𝘩𝘰𝘮𝘢𝘵𝘪𝘴 lacks stable genotypic resistance …
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Mathematical modelling of host-disease-drug interactions in HIV disease
… is crucial, particularly in the background of treatment failure having occurred previously with certain other drugs. An understanding of the dynamics of viral mutant genotypes aids in the assessment of treatment failure with a certain drug combination, and exploring potential salvage treatment …
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Client/Therapist Feedback and the Role of the Alliance on Psychotherapy Outcomes
… to identify those who are not responding to treatment and warning their therapist about the client’s risk significantly improves client outcomes in psychotherapy. Although outcomes have been improved, significant proportions of clients have treatment failures or see no improvement in therapy. …
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Recent advances in drug therapy of tuberculosis
The current medications for tuberculosis treatment could cause a lot side effects, and indirectly lead treatment failure by patient intolerance. Scientists are trying to analyze the gene differences in resistant tuberculosis isolates, find out the reason and later target mechanism could be achieved …
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Drug-drug interactions between antiretrovirals and bedaquiline
… particularly susceptible to TB infection, and treatment of HIV-TB co-infection is challenging for multiple reasons, including potential drug-interactions. Drug-resistant TB is difficult to treat and is associated with high treatment failure rates, mainly because the antimycobacterial drugs …
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Efficacy of sulfadoxine-pyrimethamine with and without artesunate for the treatment of uncomplicated malaria in Mozambique : a randomised controlled trial
… a large public health burden in Mozambique and a treatment policy with effective anti-malarials is a key component of their malaria control programme. Artemisinin-based combination therapies (ACTs) are now generally considered as the best treatment for uncomplicated falciparum malaria; the use of …
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Gastric resident systems for large dose drug delivery
… as 50-70% of patients have trouble following treatment recommendations. Whereas adherence is driven by many factors including the socioeconomic status of a patient and the quality of the health care team, drug regimen complexity also affects treatment outcomes. For example, adherence decreases …
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Evaluating diagnostic and treatment modalities in the management of benign prostatic hyperplasia in the Veterans Administration population
… guidelines, this study evaluated diagnostic and treatment modalities in BPH management in the VA population (a population with a high percentage of elderly males). A survey, containing simulated BPH patient cases, was mailed to 292 VA urologists, of which 114 (39%) responded. Urologists showed …
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Potential Approaches to Limiting Group A Streptococcus Virulence
… and site of infection. The current forms of treatment are limited, consisting of antibiotic regimens and in severe cases surgical debridement to remove infected tissue. Treatment failure has been reported in approximately 35% of GAS pharyngitis patients. It is hypothesized that a major …
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Towards Rapid Measurement of Non-Nucleoside Reverse Transcriptase Inhibitors in a Portable, Low-Cost Platform
… antiretrovirals (ARV) for HIV prevention and treatment have become very effective over the last 40 years of development, many people living with HIV (PLWH) encounter inadequately suppressed viral loads and treatment failure. Providing drug-level feedback (DLF) can identify those with …
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Long-term outcomes of women treated for high-grade squamous intraepithelial lesions at a University Hospital colposcopy unit in South Africa. A 5-year retrospective cohort study
… and cone biopsy complication rates, cure rate, treatment failure and invasive cervical cancer rates, median time from treatment to recurrence, follow-up default rates. Data were managed and analysed using IBM SPSS Statistics Version 25 and Microsoft Structured Query Language (SQL) version 2014. …
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Joint models for nonlinear longitudinal profiles in the presence of informative censoring
… in a community can only be truly combated if a treatment program is implemented which is able to clear both asexual and sexual parasites effectively. In this thesis focus will be on the modeling of the key features of gametocytemia. Particular emphasis will be on the modeling of the time to …
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Induction of metronidazole and clindamycin resistance in gardnerella vaginalis
… been an increase in recurrent BV infections and treatment failure. Antimicrobial resistance in bacteria has proven to lead to higher rates of adverse health outcomes. Understanding the susceptibility and resistance mechanisms of G. vaginalis is crucial in reducing the number of recurrent …
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Prognostic Factor Analysis of Patients with Advanced Non-Small Cell Lung Cancer Treated with Palliative Chemotherapy
… which is the most important cause of treatment failure in non small cell lung cancer (NSCLC). MATERIALS AND METHODS: Pretreatment tumor biopsy specimens from 50 patients with NSCLC stage IIIB with malignant pleural effusion or stage IV were analyzed for p53, Bcl-2, Bax and ERCC1 …
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Improving Patient Care Outcomes to Reduce Recurrent Admissions of Patients with Chronic Obstructive Pulmonary Disease
… is specific to controlling costs derived from treatment failure and hospitalization. The leading preventable risk factor associated with chronic lung disease for further study is smoking. Determining the underlying addiction and further education may also be an area for further research to …
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Improving antibiotic therapy for Mycobacterium tuberculosis
… symptoms, and high mortality rates. Current treatment outcomes for drug-resistant TB are poor due to the need for prolonged and complex regimens, which often result in significant side effects, low patient adherence, and high rates of treatment failure. These challenges highlight the urgent …
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