Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"traumatic injury"”.
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Traumatic Injury-Induced Cell Responses in Human Cortical Organoids
Traumatic brain injury (TBI) impacts millions of individuals worldwide each year, which often leads to permanent disabilities and emerges as an important risk factor for neurodegenerative diseases. This is driven by secondary injury cascades of cellular toxicity, inflammation, and aggregation of …
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Does military combat-related traumatic injury increase cardiovascular disease risk?
… evidence suggesting that combat related traumatic injury (CRTI) is associated with an increased cardiovascular (CV) disease (CVD) risk. However, data from a contemporary military population with CRTI is lacking. Hypotheses: The main hypotheses addressed in this thesis are: 1. Military …
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Major traumatic injury : serum cytokine biomarkers as predictors of poor clinical outcome
… The first phase appears within an hour of injury, presenting immediate traumatic effects due to fatal injuries and haemorrhagic shocks. The second phase is marked by onset of complications after a week, characterized by further complications such as sepsis, multiple organ dysfunction and …
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Interleukin-6 and Interleukin-10 concentrations as predictors of patient outcome following major traumatic injury
… in the days and weeksfollowing the initial traumatic insult. These complications develop due to an imbalance between the pro-inflammatory and antiinflammatoryresponse to traumatic injury. This imbalance results in the counterinflammatory response becoming dominant. This results in …
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Case study of Physical Therapy approach of patient with Anterior. Cruciate Ligament rupture after traumatic injury in skiing
… are presented. Also the mechanisms of the injury of Anterior Cruciate Ligament, the clinical examination that follows, the symptomes that correspond in this injury and the conservative therapeutic approach are discused. The second part contains a detailed description of the case study of …
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Identifying risk factors for traumatic injury (TBI) due to road traffic accidents (RTA) and strategies to reduce the burden of secondary brain injury
Background: There is a major knowledge gap in South Africa about detailed risk factors contributing to TBI due to RTAs in children. The objectives of this study were to map the burden of disease and examine circumstantial and clinical information to inform potential intervention strategies. …
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Probiotic Use in Trauma Patients: A Pathway to Determining the Standard of Care to Improve Outcomes
… for illness and infection. Patients who suffer a traumatic injury are among those at highest risk for complications associated with microbial imbalance, or dysbiosis. In addition to the mechanisms of traumatic injury that can impair one’s immune function, these patients are subjected to a variety …
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POLST-Discordant Intensive Care Near the End of Life: A Retrospective Cohort Study
… history of dementia, admitting diagnosis of traumatic injury, and whether the patient signed his/her own POLST. Main Outcome(s) and Measure(s): POLST-discordant intensive care was defined as admission to the intensive care unit or cardiopulmonary resuscitation (CPR) among patients whose …
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The effects of rapid stretch injury on rat neocortical cultures
Several key biological mechanisms of traumatic injury to axons have been elucidated using in vitro stretch injury models. These models, however, are based on the experimentation of single cultures keeping productivity slow. Indeed, low yield has hindered important and well founded investigations …
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Attributes of Astrocyte Response to Mechano-Stimulation by High-Rate Overpressure
… neurotrauma represents a significant mode of traumatic injury to the brain. The incidence of blast neurotrauma is particularly high amongst military combat personnel and can be debilitating and endure clinically for years after injury is sustained. Mechanically, blast represents a unique and …
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IMPACT OF HEALTH DISPARITIES AND BRIEF COUNSELING INTERVENTIONS ON DRINKING OUTCOMES IN HOSPITALIZED TRAUMA PATIENTS
… or have an AUD are more likely to experience a traumatic injury. As a result, hospital trauma centers are a key place to screen and provide brief interventions for risky drinking patterns. Also, there is growing effort today to understand health disparities, so that healthcare can be adjusted to …
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Cytokine and Chemokine Profiles in a Rat Model of Hemorrhagic Shock after Immuno-Modulation by Androstenetriol
… cellular and molecular mechanisms involved in traumatic injury, and how they are modulated during drug interaction, can facilitate novel treatment strategies for future trauma patients. We hypothesize that the pharmacological agent, Androstenetriol (AET), up regulates host immune response by …
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The Role of Impulsive Aggression in a Cohort of Suicide Attempters
… the experimental group and suicide ideators and traumatic injury patients as control groups. Subjects were evaluated for the presence of impulsivity and aggression during initial treatment for suicidality or unintentional injury and again three months later. Two hundred one of the initial …
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Using Oxygen Generating Materials for the Preservation of Skeletal Muscle Function & Viability in a Rodent Acute Ischemic Injury Model
Blunt force and penetration wounds can cause traumatic injury to soft tissue of varying types (i.e. skin, nerve, muscle) resulting in a decrease of tissue function and viability. A large percentage of these types of wounds are sustained to the extremities/limbs, not only in our nation’s combat …
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Mechanistic Investigation of A Hemostatic Keratin Biomaterial
Traumatic injury leads to more productive years lost than heart disease, cancer and stroke combined. Trauma is often accompanied and complicated by uncontrolled bleeding. Human hair keratin biomaterials have demonstrated efficacy in controlling hemorrhage in both small and large animal models; …
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Investigating Interleukin – 8 and TGF Beta as early biomarkers predicting poor clinical outcome in major trauma
… leading cause of death and disability. Globally, traumatic injury is the main cause of death under the age of 45. Recent studies from the UK report a demographic change in major trauma. The most common mechanism of traumatic injury is falling from less than 2 meters, with the primary demographic …
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Multi well uni-axial stretch injury device
Most diffuse brain injury is the result of uni-axial stretch of brain axons in traumatic brain injury. Traumatic injury to axons throughout the brain and is believed to be a major cause for coma, and other complications. Diffuse axonal injury is mostly multi-focal and appears throughout the deep …
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