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Showing 1 to 6 of 6 for “"trauma induced coagulopathy"”.
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Identification of Multiple Levels of Trauma Induced Coagulopathy
Trauma continues to be a major cause of death across the globe. While the exact causes of trauma differ greatly between the military and civilian lifestyles, the ability to stop bleeding after trauma is paramount for survival. Over the past decade coagulation research has transitioned from a …
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The impact of thromboelastography on patients with penetrating abdominal trauma requiring intensive care
Background Trauma induced coagulopathy is a complex multifaceted process which contributes to higher mortality rates in severely injured trauma patients. Thromboelastography (TEG) is an effective test to detect TIC which assists in instituting goal directed therapy as part of damage control …
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Spectrum of coagulation profiles in severely injured patients: A subgroup analysis from the FIRST ( Fluids in Resuscitation of Severe Trauma) trial
… in both the civilian and military settings. Trauma induced coagulopathy (TIC) is now widely accepted as a major contributing factor to worsening bleeding in these patients. A quarter of severe trauma patients present with coagulopathy on admission and remain a group with high morbidity and …
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In-vitro Clot Formation and Failure
A primary cause of bleeding and mortality after traumatic injury is failure of hemostatic clot formation at wound sites. After trauma, approximately 25-30% of severe injured patients display trauma induced coagulopathy (TIC) which is a multifactorial condition that causes poor clot formation and …
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Microfluidic Approaches to Thrombosis and Hemostasis: Towards a Patient-Specific Test of Antiplatelet Therapeutics and the Assessment of Coagulopathy in Hemophilic and Trauma Patients
… of platelet function in whole blood from trauma patients during the acute phase of trauma-induced coagulopathy. The development of microfluidics, microfabrication, and its applications in hemostasis and thrombosis is essential in advancing our knowledge of clinical and pathological …
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Platelet phenotype distinguishes ITP from isolated thrombocytopenia
… assay was developed to evaluate autoantibody-induced platelet receptor shedding. To assess the molecular pathways of platelet-autoantibody engagement, soluble receptor release was measured in the presence of an FcgRIIa-blocking antibody or a broad-spectrum metalloproteinase inhibitor, …